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Term:execution phase of necroptosis
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Accession:GO:0097528 term browser browse the term
Definition:A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.
Synonyms:exact_synonym: execution phase of necroptotic process;   necroptotic execution phase
 broad_synonym: necroptosis

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execution phase of necroptosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlkl mixed lineage kinase domain like pseudokinase JBrowse link 19 43,508,416 43,535,050 RGD:1624291
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1600115

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  biological_process 19858
    cellular process 18617
      execution phase of necroptosis 2
Path 2
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  biological_process 19858
    cellular process 18617
      cell death 2138
        programmed cell death 1953
          programmed necrotic cell death 45
            necroptotic process 35
              execution phase of necroptosis 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.