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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase complex, class I
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Accession:GO:0097651 term browser browse the term
Definition:A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.
Synonyms:exact_synonym: class I PI3K complex


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phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IBA
(PMID:22402981)
PMID:21873635
RGD PMID:22402981, PMID:21873635 RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO
IBA
(PMID:12507995)
PMID:21873635
RGD PMID:12507995, PMID:21873635 RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA
ISO
GO_REF:0000002
(PMID:12507995)
InterPro
RGD
PMID:12507995 GO_REF:0000002 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 ISO (MGI:3574247|PMID:15797027) RGD PMID:15797027 MGI:3574247 NCBI chr10:55,085,269...55,135,069
Ensembl chr10:55,085,259...55,135,092
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20602
    cellular anatomical entity 20292
      extrinsic component of membrane 337
        phosphatidylinositol 3-kinase complex 31
          phosphatidylinositol 3-kinase complex, class I 6
            phosphatidylinositol 3-kinase complex, class IA 4
            phosphatidylinositol 3-kinase complex, class IB 5
Path 2
Term Annotations click to browse term
  cellular_component 20602
    protein-containing complex 6103
      catalytic complex 1496
        transferase complex 821
          transferase complex, transferring phosphorus-containing groups 266
            phosphatidylinositol 3-kinase complex 31
              phosphatidylinositol 3-kinase complex, class I 6
                phosphatidylinositol 3-kinase complex, class IA 4
                phosphatidylinositol 3-kinase complex, class IB 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.