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Accession:GO:0097707 term browser browse the term
Definition:A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
Synonyms:related_synonym: iron-dependent programmed cell death

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negative regulation of ferroptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm2 apoptosis inducing factor, mitochondria associated 2 ISO (PMID:31634899), (PMID:31634900) RGD PMID:31634899, PMID:31634900 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Gpx4 glutathione peroxidase 4 ISS
(MGI:MGI:5615528|PMID:25402683), (MGI:MGI:6114953|PMID:29290465)
PMID:25402683, PMID:29290465 GO_REF:0000024, MGI:MGI:5615528, MGI:MGI:6114953 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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  biological_process 20028
    cellular process 18800
      cell death 2137
        programmed cell death 1948
          ferroptosis 2
            negative regulation of ferroptosis 2
            regulation of ferroptosis + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.