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ONTOLOGY REPORT - ANNOTATIONS


Term:calcineurin-mediated signaling
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Accession:GO:0097720 term browser browse the term
Definition:Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.
Synonyms:exact_synonym: calcineurin-mediated signalling
 related_synonym: calcineurin signaling


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calcineurin-mediated signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:12904895
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 JBrowse link 3 22,998,900 23,020,441 RGD:12904895
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 JBrowse link 13 53,750,470 53,870,288 RGD:12904895
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:13792537
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:13792537
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:13792537
calcineurin-NFAT signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb2 adhesion G protein-coupled receptor B2 JBrowse link 5 148,168,530 148,231,587 RGD:1624291
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:13792537
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:1624291
RGD:13792537
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1624291
RGD:13792537
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1624291
RGD:13792537
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:1624291
RGD:13792537
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:13792537
RGD:1624291
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1600115
RGD:1624291
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:1624291
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:1624291
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:1624291
G Rcan2 regulator of calcineurin 2 JBrowse link 9 19,518,568 19,749,145 RGD:1624291
negative regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn3 actinin alpha 3 JBrowse link 1 220,120,532 220,136,460 RGD:1624291
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:10047333
RGD:1624291
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:1624291
RGD:1600115
G Cmya5 cardiomyopathy associated 5 JBrowse link 2 22,646,694 22,744,536 RGD:1624291
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 7 61,785,423 61,816,775 RGD:1624291
G Fhl2 four and a half LIM domains 2 JBrowse link 9 49,920,611 49,994,906 RGD:13601990
RGD:13792537
RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1600115
RGD:1624291
G Homer2 homer scaffold protein 2 JBrowse link 1 143,443,300 143,535,579 RGD:1600115
RGD:1624291
G Homer3 homer scaffold protein 3 JBrowse link 16 20,880,447 20,890,968 RGD:1600115
RGD:1624291
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
G Myoz1 myozenin 1 JBrowse link 15 4,077,066 4,084,306 RGD:1624291
G Myoz2 myozenin 2 JBrowse link 2 227,180,887 227,207,629 RGD:1624291
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:1624291
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:1600115
RGD:1624291
G Tbc1d10c TBC1 domain family, member 10C JBrowse link 1 219,431,094 219,439,102 RGD:1624291
positive regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap5 A-kinase anchoring protein 5 JBrowse link 6 99,356,509 99,361,909 RGD:13507305
G Akap6 A-kinase anchoring protein 6 JBrowse link 6 73,553,111 73,991,992 RGD:2312613
G Camta1 calmodulin binding transcription activator 1 JBrowse link 5 168,138,207 169,017,295 RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
G Cherp calcium homeostasis endoplasmic reticulum protein JBrowse link 16 19,068,783 19,081,837 RGD:1624291
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:1624291
RGD:1600115
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:1624291
RGD:8554486
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:1624291
RGD:1600115
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Lmcd1 LIM and cysteine-rich domains 1 JBrowse link 4 144,192,989 144,252,554 RGD:1624291
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
RGD:1600115
G Ptbp1 polypyrimidine tract binding protein 1 JBrowse link 7 12,663,965 12,673,723 RGD:1624291
G RGD1564899 similar to chromosome 10 open reading frame 71 JBrowse link 16 8,879,907 8,907,462 RGD:13602000
RGD:1624291
G Slc12a1 solute carrier family 12 member 1 JBrowse link 3 117,421,531 117,498,372 RGD:1624291
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:1624291
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:1624291
G Tmem110 transmembrane protein 110 JBrowse link 16 6,903,212 6,958,786 RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
regulation of calcineurin-mediated signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc8a2 solute carrier family 8 member A2 JBrowse link 1 78,029,555 78,054,042 RGD:1600115
RGD:1624291
regulation of calcineurin-NFAT signaling cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efhb EF hand domain family, member B JBrowse link 9 47,988 120,800 RGD:1624291
G Mir1 microRNA 1 JBrowse link 18 2,054,933 2,055,019 RGD:1624291
G Mir1b microRNA 1b JBrowse link 3 175,769,716 175,769,800 RGD:1624291
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:1624291
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:13792537
G Rcan2 regulator of calcineurin 2 JBrowse link 9 19,518,568 19,749,145 RGD:13792537
G Rcan3 RCAN family member 3 JBrowse link 5 153,773,461 153,790,271 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        intracellular signal transduction 2597
          second-messenger-mediated signaling 481
            calcium-mediated signaling 233
              calcineurin-mediated signaling 53
                calcineurin-NFAT signaling cascade + 49
                negative regulation of calcineurin-mediated signaling + 16
                positive regulation of calcineurin-mediated signaling + 18
                regulation of calcineurin-mediated signaling + 41
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              second-messenger-mediated signaling 481
                calcium-mediated signaling 233
                  calcineurin-mediated signaling 53
                    calcineurin-NFAT signaling cascade + 49
                    negative regulation of calcineurin-mediated signaling + 16
                    positive regulation of calcineurin-mediated signaling + 18
                    regulation of calcineurin-mediated signaling + 41
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.