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ONTOLOGY REPORT - ANNOTATIONS


Term:extracellular exosome biogenesis
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Accession:GO:0097734 term browser browse the term
Definition:The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Synonyms:exact_synonym: exosome assembly or secretion;   exosome biogenesis;   exosome production
 related_synonym: ILV assembly;   intraluminal vesicle assembly


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extracellular exosome biogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
exosomal secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:1624291
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:1624291
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291
extracellular exosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd34 CD34 molecule JBrowse link 13 113,691,842 113,711,259 RGD:1624291
RGD:1600115
negative regulation of exosomal secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
G Vps4b vacuolar protein sorting 4 homolog B JBrowse link 13 26,825,261 26,850,460 RGD:1624291
positive regulation of exosomal secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
G Chmp2a charged multivesicular body protein 2A JBrowse link 1 65,540,808 65,543,708 RGD:1624291
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:1600115
RGD:1624291
G Myo5b myosin Vb JBrowse link 18 70,426,865 70,729,985 RGD:11533643
G Pdcd6ip programmed cell death 6 interacting protein JBrowse link 8 121,916,233 121,973,145 RGD:1624291
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
G Sdc1 syndecan 1 JBrowse link 6 33,885,576 33,908,038 RGD:1624291
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:1624291
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:10054083
G Snf8 SNF8 subunit of ESCRT-II JBrowse link 10 83,856,331 83,868,621 RGD:1624291
G Stam signal transducing adaptor molecule JBrowse link 17 81,209,795 81,256,111 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:1624291
G Vps4b vacuolar protein sorting 4 homolog B JBrowse link 13 26,825,261 26,850,460 RGD:1624291
positive regulation of extracellular exosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdcd6ip programmed cell death 6 interacting protein JBrowse link 8 121,916,233 121,973,145 RGD:1624291
G Sdc1 syndecan 1 JBrowse link 6 33,885,576 33,908,038 RGD:1624291
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:1624291
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
regulation of exosomal secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp3 charged multivesicular body protein 3 JBrowse link 4 99,449,213 99,496,156 RGD:1624291
G Chmp6 charged multivesicular body protein 6 JBrowse link 10 109,073,678 109,079,348 RGD:1624291
regulation of extracellular exosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdcd6ip programmed cell death 6 interacting protein JBrowse link 8 121,916,233 121,973,145 RGD:1624291
G Stam signal transducing adaptor molecule JBrowse link 17 81,209,795 81,256,111 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19335
    cellular component organization or biogenesis 6441
      cellular component biogenesis 3051
        extracellular vesicle biogenesis 25
          extracellular exosome biogenesis 23
            exosomal secretion + 22
            extracellular exosome assembly + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.