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ONTOLOGY REPORT - ANNOTATIONS


Term:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
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Accession:GO:0098535 term browser browse the term
Definition:Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.
Comment:In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
Synonyms:exact_synonym: de novo centriole assembly via deuterosome
 broad_synonym: de novo centriole assembly
 related_synonym: centriole amplification;   deuterosomal basal body biogenesis;   deuterosome pathway;   deuterosome-mediated centriole biogenesis;   multiciliation;   multiciliogenesis


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de novo centriole assembly involved in multi-ciliated epithelial cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CEP152 centrosomal protein 152 JBrowse link 1 122,876,146 122,979,851 RGD:14298760
G CEP63 centrosomal protein 63 JBrowse link 13 75,605,622 75,707,087 RGD:14298760
G DEUP1 deuterosome assembly protein 1 JBrowse link 9 25,688,394 25,893,105 RGD:14298760
G PLK4 polo like kinase 4 JBrowse link 8 96,989,011 97,013,324 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15257
    cellular component organization or biogenesis 4693
      cellular component organization 4540
        microtubule organizing center organization 107
          centriole assembly 36
            de novo centriole assembly 4
              de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 4
Path 2
Term Annotations click to browse term
  biological_process 15257
    cellular process 13567
      cellular component organization 4540
        organelle organization 2866
          cytoskeleton organization 1056
            microtubule cytoskeleton organization 470
              microtubule organizing center organization 107
                centriole assembly 36
                  de novo centriole assembly 4
                    de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.