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ONTOLOGY REPORT - ANNOTATIONS


Term:detoxification
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Accession:GO:0098754 term browser browse the term
Definition:Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.


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aflatoxin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKR7A3 aldo-keto reductase family 7 member A3 JBrowse link 1 19,274,229 19,289,362 RGD:2290271
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:2290271
cellular detoxification of aldehyde term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKR1A1 aldo-keto reductase family 1 member A1 JBrowse link 1 45,550,779 45,570,051 RGD:2290271
G AKR1B10 aldo-keto reductase family 1 member B10 JBrowse link 7 134,527,592 134,541,414 RGD:2290271
G RDH11 retinol dehydrogenase 11 JBrowse link 14 67,676,800 67,695,793 RGD:2290271
G RDH12 retinol dehydrogenase 12 JBrowse link 14 67,701,886 67,734,451 RGD:2290271
cellular detoxification of nitrogen compound term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GSTM1 glutathione S-transferase mu 1 JBrowse link 1 109,687,796 109,693,745 RGD:2290271
G GSTM2 glutathione S-transferase mu 2 JBrowse link 1 109,668,022 109,683,997 RGD:2290271
G GSTM3 glutathione S-transferase mu 3 JBrowse link 1 109,733,932 109,741,038 RGD:2290271
cellular oxidant detoxification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALB albumin JBrowse link 4 73,404,239 73,421,484 RGD:2290271
G ALOX5AP arachidonate 5-lipoxygenase activating protein JBrowse link 13 30,713,478 30,764,428 RGD:2290271
G APOE apolipoprotein E JBrowse link 19 44,905,749 44,909,395 RGD:2290271
G APOM apolipoprotein M JBrowse link 6 31,652,410 31,658,210 RGD:2290271
G CAT catalase JBrowse link 11 34,438,925 34,472,060 RGD:2290271
G CLIC2 chloride intracellular channel 2 JBrowse link X 155,276,207 155,334,681 RGD:2290271
G CYGB cytoglobin JBrowse link 17 76,527,348 76,557,692 RGD:2290271
G DUOX1 dual oxidase 1 JBrowse link 15 45,129,994 45,165,578 RGD:2290271
G DUOX2 dual oxidase 2 JBrowse link 15 45,092,648 45,114,161 RGD:2290271
G EPX eosinophil peroxidase JBrowse link 17 58,192,724 58,205,174 RGD:2290271
G FABP1 fatty acid binding protein 1 JBrowse link 2 88,122,982 88,128,131 RGD:2290271
G GPX1 glutathione peroxidase 1 JBrowse link 3 49,357,171 49,358,600 RGD:2290271
G GPX2 glutathione peroxidase 2 JBrowse link 14 64,939,152 64,942,905 RGD:2290271
G GPX3 glutathione peroxidase 3 JBrowse link 5 151,020,412 151,028,993 RGD:2290271
G GPX4 glutathione peroxidase 4 JBrowse link 19 1,103,926 1,106,789 RGD:2290271
G GPX5 glutathione peroxidase 5 JBrowse link 6 28,526,012 28,534,951 RGD:2290271
G GPX6 glutathione peroxidase 6 JBrowse link 6 28,503,296 28,515,793 RGD:2290271
G GPX7 glutathione peroxidase 7 JBrowse link 1 52,602,371 52,609,051 RGD:2290271
G GPX8 glutathione peroxidase 8 (putative) JBrowse link 5 55,160,118 55,167,301 RGD:2290271
G GSR glutathione-disulfide reductase JBrowse link 8 30,678,061 30,727,999 RGD:2290271
G GSTA1 glutathione S-transferase alpha 1 JBrowse link 6 52,791,380 52,803,967 RGD:2290271
G GSTK1 glutathione S-transferase kappa 1 JBrowse link 7 143,263,429 143,269,129 RGD:2290271
G GSTM2 glutathione S-transferase mu 2 JBrowse link 1 109,668,022 109,683,997 RGD:2290271
G GSTO1 glutathione S-transferase omega 1 JBrowse link 10 104,254,194 104,267,464 RGD:2290271
G GSTO2 glutathione S-transferase omega 2 JBrowse link 10 104,267,626 104,304,948 RGD:2290271
G GSTP1 glutathione S-transferase pi 1 JBrowse link 11 67,583,595 67,586,653 RGD:2290271
G GSTT1 glutathione S-transferase theta 1 RGD:2290271
G GSTZ1 glutathione S-transferase zeta 1 JBrowse link 14 77,320,887 77,331,597 RGD:2290271
G HBA1 hemoglobin subunit alpha 1 JBrowse link 16 176,651 177,522 RGD:2290271
G HBA2 hemoglobin subunit alpha 2 JBrowse link 16 172,847 173,710 RGD:2290271
G HBB hemoglobin subunit beta JBrowse link 11 5,225,466 5,227,071 RGD:2290271
G HBD hemoglobin subunit delta JBrowse link 11 5,232,829 5,234,628 RGD:2290271
G HBE1 hemoglobin subunit epsilon 1 JBrowse link 11 5,268,350 5,270,143 RGD:2290271
G HBG1 hemoglobin subunit gamma 1 JBrowse link 11 5,248,272 5,249,857 RGD:2290271
G HBG2 hemoglobin subunit gamma 2 JBrowse link 11 5,253,191 5,254,781 RGD:2290271
G HBM hemoglobin subunit mu JBrowse link 16 165,974 166,768 RGD:2290271
G HBQ1 hemoglobin subunit theta 1 JBrowse link 16 180,334 181,179 RGD:2290271
G HBZ hemoglobin subunit zeta JBrowse link 16 142,422 154,511 RGD:2290271
G HP haptoglobin JBrowse link 16 72,054,592 72,061,056 RGD:2290271
G IPCEF1 interaction protein for cytohesin exchange factors 1 JBrowse link 6 154,154,483 154,356,766 RGD:2290271
G IYD iodotyrosine deiodinase JBrowse link 6 150,368,854 150,404,629 RGD:2290271
G KDM3B lysine demethylase 3B JBrowse link 5 138,352,596 138,437,027 RGD:2290271
G LOXHD1 lipoxygenase homology domains 1 JBrowse link 18 46,476,972 46,657,115 RGD:2290271
G LPO lactoperoxidase JBrowse link 17 58,238,426 58,268,518 RGD:2290271
G LTC4S leukotriene C4 synthase JBrowse link 5 179,793,985 179,796,512 RGD:2290271
G MGST1 microsomal glutathione S-transferase 1 JBrowse link 12 16,347,142 16,377,189 RGD:2290271
G MGST2 microsomal glutathione S-transferase 2 JBrowse link 4 139,665,725 139,754,608 RGD:2290271
G MGST3 microsomal glutathione S-transferase 3 JBrowse link 1 165,630,873 165,656,136 RGD:2290271
G MPO myeloperoxidase JBrowse link 17 58,269,856 58,280,935 RGD:2290271
G NNT nicotinamide nucleotide transhydrogenase JBrowse link 5 43,601,092 43,705,566 RGD:2290271
G NXN nucleoredoxin JBrowse link 17 799,313 979,766 RGD:2290271
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,282 RGD:2290271
G PRDX1 peroxiredoxin 1 JBrowse link 1 45,511,035 45,522,890 RGD:2290271
G PRDX2 peroxiredoxin 2 JBrowse link 19 12,796,820 12,801,910 RGD:2290271
G PRDX3 peroxiredoxin 3 JBrowse link 10 119,167,699 119,178,865 RGD:2290271
G PRDX4 peroxiredoxin 4 JBrowse link X 23,664,260 23,686,399 RGD:2290271
G PRDX5 peroxiredoxin 5 JBrowse link 11 64,318,088 64,321,823 RGD:2290271
G PRDX6 peroxiredoxin 6 JBrowse link 1 173,477,347 173,488,807 RGD:2290271
G PRXL2A peroxiredoxin like 2A JBrowse link 10 80,407,829 80,437,115 RGD:2290271
G PRXL2B peroxiredoxin like 2B JBrowse link 1 2,586,460 2,591,469 RGD:2290271
G PRXL2C peroxiredoxin like 2C JBrowse link 9 96,641,251 96,655,331 RGD:2290271
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 122,369,906 122,395,703 RGD:2290271
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 186,671,812 186,680,427 RGD:2290271
G PXDN peroxidasin JBrowse link 2 1,631,887 1,744,852 RGD:2290271
G PXDNL peroxidasin like JBrowse link 8 51,319,575 51,809,445 RGD:2290271
G RP1 RP1 axonemal microtubule associated JBrowse link 8 54,509,448 54,630,834 RGD:2290271
G S100A9 S100 calcium binding protein A9 JBrowse link 1 153,357,854 153,361,027 RGD:2290271
G SELENOS selenoprotein S JBrowse link 15 101,270,909 101,277,520 RGD:2290271
G SELENOT selenoprotein T JBrowse link 3 150,603,263 150,630,447 RGD:2290271
G SELENOW selenoprotein W JBrowse link 19 47,778,572 47,784,681 RGD:2290271
G SESN1 sestrin 1 JBrowse link 6 108,986,437 109,094,505 RGD:2290271
G SESN2 sestrin 2 JBrowse link 1 28,259,452 28,282,491 RGD:2290271
G SRXN1 sulfiredoxin 1 JBrowse link 20 646,615 653,370 RGD:2290271
G TP53INP1 tumor protein p53 inducible nuclear protein 1 JBrowse link 8 94,925,972 94,949,387 RGD:2290271
G TPO thyroid peroxidase JBrowse link 2 1,413,288 1,542,727 RGD:2290271
G TXN thioredoxin JBrowse link 9 110,243,812 110,256,640 RGD:2290271
G TXNDC17 thioredoxin domain containing 17 JBrowse link 17 6,640,902 6,644,541 RGD:2290271
G TXNDC2 thioredoxin domain containing 2 JBrowse link 18 9,885,726 9,888,159 RGD:2290271
G TXNRD1 thioredoxin reductase 1 JBrowse link 12 104,215,779 104,350,307 RGD:2290271
G TXNRD2 thioredoxin reductase 2 JBrowse link 22 19,875,518 19,941,992 RGD:2290271
G TXNRD3 thioredoxin reductase 3 JBrowse link 3 126,607,052 126,655,124 RGD:2290271
G UBIAD1 UbiA prenyltransferase domain containing 1 JBrowse link 1 11,273,198 11,299,572 RGD:2290271
detoxification of cadmium ion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLC30A1 solute carrier family 30 member 1 JBrowse link 1 211,575,039 211,578,757 RGD:2290271
detoxification of copper ion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATP7A ATPase copper transporting alpha JBrowse link X 77,910,656 78,050,395 RGD:2290271
G MT1A metallothionein 1A JBrowse link 16 56,638,666 56,640,087 RGD:2290271
G MT1B metallothionein 1B JBrowse link 16 56,651,899 56,653,204 RGD:2290271
G MT1DP metallothionein 1D, pseudogene JBrowse link 16 56,643,687 56,644,941 RGD:2290271
G MT1E metallothionein 1E JBrowse link 16 56,625,673 56,627,112 RGD:2290271
G MT1F metallothionein 1F JBrowse link 16 56,657,943 56,659,303 RGD:2290271
G MT1G metallothionein 1G JBrowse link 16 56,666,735 56,668,065 RGD:2290271
G MT1H metallothionein 1H JBrowse link 16 56,669,814 56,671,129 RGD:2290271
G MT1HL1 metallothionein 1H like 1 JBrowse link 1 237,004,103 237,004,418 RGD:2290271
G MT1L metallothionein 1L, pseudogene JBrowse link 16 56,617,461 56,618,818 RGD:2290271
G MT1M metallothionein 1M JBrowse link 16 56,632,622 56,633,986 RGD:2290271
G MT1X metallothionein 1X JBrowse link 16 56,682,470 56,684,196 RGD:2290271
G MT2A metallothionein 2A JBrowse link 16 56,608,533 56,609,497 RGD:2290271
G MT3 metallothionein 3 JBrowse link 16 56,589,337 56,591,088 RGD:2290271
G MT4 metallothionein 4 JBrowse link 16 56,565,049 56,568,957 RGD:2290271
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,282 RGD:2290271
detoxification of mercury ion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,282 RGD:2290271
detoxification of nitrogen compound term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MARC1 mitochondrial amidoxime reducing component 1 JBrowse link 1 220,786,697 220,814,399 RGD:2290271
G MARC2 mitochondrial amidoxime reducing component 2 JBrowse link 1 220,747,417 220,784,815 RGD:2290271
formaldehyde catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 4 99,123,657 99,144,298 RGD:2290271
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 4 99,070,978 99,088,788 RGD:2290271
G ESD esterase D JBrowse link 13 46,771,256 46,797,700 RGD:2290271
guanine deglycation, methylglyoxal removal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,282 RGD:2290271
phenylacetate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACAA1 acetyl-CoA acyltransferase 1 JBrowse link 3 38,122,710 38,137,242 RGD:2290271
G PON3 paraoxonase 3 JBrowse link 7 95,359,872 95,396,375 RGD:2290271
positive regulation of superoxide dismutase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,961,654 7,985,282 RGD:2290271
G RGN regucalcin JBrowse link X 47,078,355 47,093,314 RGD:2290271
G TNF tumor necrosis factor JBrowse link 6 31,575,567 31,578,336 RGD:2290271
regulation of removal of superoxide radicals term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BMP7 bone morphogenetic protein 7 JBrowse link 20 57,168,753 57,266,651 RGD:2290271
G CD36 CD36 molecule JBrowse link 7 80,602,188 80,679,277 RGD:2290271
G DHFR dihydrofolate reductase JBrowse link 5 80,626,226 80,654,981 RGD:2290271
G DHFRP1 dihydrofolate reductase pseudogene 1 JBrowse link 18 26,167,862 26,171,357 RGD:2290271
G FBLN5 fibulin 5 JBrowse link 14 91,869,411 91,947,702 RGD:2290271
G GCH1 GTP cyclohydrolase 1 JBrowse link 14 54,842,005 54,902,824 RGD:2290271
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:2290271
regulation of superoxide dismutase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SZT2 SZT2 subunit of KICSTOR complex JBrowse link 1 43,389,884 43,454,247 RGD:2290271
removal of superoxide radicals term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APOA4 apolipoprotein A4 JBrowse link 11 116,820,702 116,823,295 RGD:2290271
G ATP7A ATPase copper transporting alpha JBrowse link X 77,910,656 78,050,395 RGD:2290271
G CCS copper chaperone for superoxide dismutase JBrowse link 11 66,593,162 66,606,019 RGD:2290271
G FANCC FA complementation group C JBrowse link 9 95,099,054 95,317,730 RGD:2290271
G MPO myeloperoxidase JBrowse link 17 58,269,856 58,280,935 RGD:2290271
G MT3 metallothionein 3 JBrowse link 16 56,589,337 56,591,088 RGD:2290271
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,056 151,014,599 RGD:2290271
G NQO1 NAD(P)H quinone dehydrogenase 1 JBrowse link 16 69,709,401 69,726,668 RGD:2290271
G PRDX1 peroxiredoxin 1 JBrowse link 1 45,511,035 45,522,890 RGD:2290271
G PRDX2 peroxiredoxin 2 JBrowse link 19 12,796,820 12,801,910 RGD:2290271
G SOD1 superoxide dismutase 1 JBrowse link 21 31,659,622 31,668,931 RGD:2290271
G SOD2 superoxide dismutase 2 JBrowse link 6 159,679,064 159,762,529 RGD:2290271
G SOD3 superoxide dismutase 3 JBrowse link 4 24,795,463 24,800,845 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17656
    detoxification 130
      cellular detoxification + 111
      cellular detoxification of methylglyoxal + 1
      detoxification of arsenic-containing substance 0
      detoxification of inorganic compound + 17
      detoxification of nitrogen compound + 5
      detoxification of zinc ion 0
      mycothiol-dependent detoxification 0
      toxin catabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 17656
    response to stimulus 9228
      response to chemical 4752
        response to toxic substance 525
          detoxification 130
            cellular detoxification + 111
            cellular detoxification of methylglyoxal + 1
            detoxification of arsenic-containing substance 0
            detoxification of inorganic compound + 17
            detoxification of nitrogen compound + 5
            detoxification of zinc ion 0
            mycothiol-dependent detoxification 0
            toxin catabolic process + 4
paths to the root