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ONTOLOGY REPORT - ANNOTATIONS


Term:response to mitochondrial depolarisation
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Accession:GO:0098780 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria.


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response to mitochondrial depolarisation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 ISO UniProtKB:Q9BXM7 (PMID:21753002), (PMID:25215947) RGD PMID:21753002, PMID:25215947 NCBI chr 3:80,634,470...80,830,068
Ensembl chr 3:80,634,470...80,830,068
JBrowse link
G Atg13 autophagy related 13 ISO (MGI:MGI:5607224|PMID:21855797) RGD PMID:21855797 MGI:MGI:5607224 NCBI chr 3:80,580,549...80,614,554
Ensembl chr 3:80,581,247...80,601,410
JBrowse link
G Atg14 autophagy related 14 ISO (PMID:23878393) RGD PMID:23878393 NCBI chr15:24,343,418...24,374,776
Ensembl chr15:24,343,314...24,374,753
JBrowse link
G Becn1 beclin 1 ISO (PMID:23878393) RGD PMID:23878393 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:6148396|PMID:29499132) RGD PMID:29499132 MGI:MGI:6148396 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Sqstm1 sequestosome 1 ISO UniProtKB:Q9JK66 (PMID:20457763) RGD PMID:20457763 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO (MGI:MGI:5607224|PMID:21855797) RGD PMID:21855797 MGI:MGI:5607224 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra2 HtrA serine peptidase 2 ISO (MGI:MGI:5581539|PMID:24709290) RGD PMID:24709290 MGI:MGI:5581539 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vps13c vacuolar protein sorting 13 homolog C ISO
ISS
(PMID:26942284)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:26942284 GO_REF:0000024 NCBI chr 8:73,682,814...73,843,290
Ensembl chr 8:73,682,887...73,842,928
JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 ISO UniProtKB:Q9JK66|UniProtKB:Q9Z2V5 (PMID:20457763) RGD PMID:20457763 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Mfn2 mitofusin 2 ISO (MGI:MGI:5498413|PMID:23620051) RGD PMID:23620051 MGI:MGI:5498413 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Optn optineurin IEA
ISO
GO_REF:0000107
(PMID:25294927)
Ensembl
RGD
PMID:25294927 GO_REF:0000107 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:19029340) RGD PMID:19029340 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO (MGI:MGI:5298125|PMID:22020285) RGD PMID:22020285 MGI:MGI:5298125 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 ISO (PMID:24005319) RGD PMID:24005319 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Gba glucosylceramidase beta ISO (MGI:MGI:5501380|PMID:23707074) RGD PMID:23707074 MGI:MGI:5501380 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Hk2 hexokinase 2 ISO (PMID:23962723) RGD PMID:23962723 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (MGI:MGI:5581539|PMID:24709290) RGD PMID:24709290 MGI:MGI:5581539 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Pink1 PTEN induced kinase 1 IMP RGD PMID:25154397 RGD:12904014 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO
IEA
(MGI:MGI:5607224|PMID:21855797)
GO_REF:0000107
RGD
Ensembl
PMID:21855797 GO_REF:0000107, MGI:MGI:5607224 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Hdac6 histone deacetylase 6 ISO UniProtKB:Q9JK66 (MGI:MGI:5616310|PMID:20457763) RGD PMID:20457763 MGI:MGI:5616310 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 IEA
ISO
GO_REF:0000107
(PMID:30217973)
Ensembl
RGD
PMID:30217973 GO_REF:0000107 NCBI chr  X:21,474,627...21,603,348
Ensembl chr  X:21,499,934...21,598,876
JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:20871098) RGD PMID:20871098 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:20457763), (PMID:20871098), (PMID:23212910) RGD PMID:20457763, PMID:20871098, PMID:23212910 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO (PMID:24270810) RGD PMID:24270810 NCBI chr 4:7,835,949...7,842,790
Ensembl chr 4:7,835,949...7,842,789
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to stress 4059
        cellular response to stress 1992
          response to mitochondrial depolarisation 22
            regulation of autophagy of mitochondrion in response to mitochondrial depolarization + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.