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ONTOLOGY REPORT - ANNOTATIONS


Term:xenophagy
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Accession:GO:0098792 term browser browse the term
Definition:The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.
Comment:While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.


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xenophagy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025818.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:51,786,459...51,787,151 JBrowse link
G Atg16l1 autophagy related 16-like 1 ISO PR:Q80W47 (MGI:MGI:5605433|PMID:24954904) RGD PMID:24954904 MGI:MGI:5605433 NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 ISO (PMID:25771791) RGD PMID:25771791 NCBI chr10:83,935,087...83,963,750 JBrowse link
G Lgals8 galectin 8 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:22246324), (PMID:28077878)
GO_Central
Ensembl
RGD
PMID:22246324, PMID:28077878 GO_REF:0000024, GO_REF:0000107 NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870
JBrowse link
G Wipi2 WD repeat domain, phosphoinositide interacting 2 ISO PR:Q8C0J2 (MGI:MGI:5605433|PMID:24954904) RGD PMID:24954904 MGI:MGI:5605433 NCBI chr12:13,969,704...13,998,134
Ensembl chr12:13,969,586...13,998,172
JBrowse link
positive regulation of xenophagy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 ISO (PMID:23245322) RGD PMID:23245322 NCBI chr 3:11,970,401...12,009,463
Ensembl chr 3:11,972,813...12,007,570
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO MGI:MGI:1346858 (MGI:MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:MGI:5299952 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 ISO MGI:MGI:2674231 (MGI:MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:MGI:5299952 NCBI chr 4:85,123,965...85,175,206
Ensembl chr 4:85,123,960...85,174,951
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO MGI:MGI:3529594 (MGI:MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:MGI:5299952 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Optn optineurin ISO
IEA
(PMID:21617041)
GO_REF:0000107
RGD
Ensembl
PMID:21617041 GO_REF:0000107 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 ISO MGI:MGI:2660793 (MGI:MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:MGI:5299952 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Tbk1 TANK-binding kinase 1 ISO (MGI:MGI:5645201|PMID:21617041) RGD PMID:21617041 MGI:MGI:5645201 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tlr2 toll-like receptor 2 ISO MGI:MGI:2674036 (MGI:MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:MGI:5299952 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    interspecies interaction between organisms 1911
      response to other organism 1702
        defense response to other organism 1113
          xenophagy 13
            negative regulation of xenophagy 0
            positive regulation of xenophagy 8
            regulation of xenophagy + 8
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      catabolic process 2543
        cellular catabolic process 2170
          autophagy 464
            macroautophagy 225
              selective autophagy 67
                xenophagy 13
                  negative regulation of xenophagy 0
                  positive regulation of xenophagy 8
                  regulation of xenophagy + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.