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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitinyl hydrolase activity
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Accession:GO:0101005 term browser browse the term
Definition:Catalysis of the hydrolysis of ubiquitin from proteins and other molecules.
Comment:There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
Synonyms:exact_synonym: deubiquitinase activity
 narrow_synonym: ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
 alt_id: GO:1904265


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ubiquitinyl hydrolase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1624291
G Uchl3 ubiquitin C-terminal hydrolase L3 JBrowse link 15 86,153,624 86,198,127 RGD:1624291
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:1624291
G Usp46 ubiquitin specific peptidase 46 JBrowse link 14 36,687,134 36,755,360 RGD:1624291
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:1624291
G Usp53 ubiquitin specific peptidase 53 JBrowse link 2 227,098,795 227,160,385 RGD:1624291
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:1624291
RGD:1600115
G Usp9x ubiquitin specific peptidase 9, X-linked JBrowse link X 10,510,033 10,660,555 RGD:1624291
Lys48-specific deubiquitinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07010717.1 RGD:13792537
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:1624291
RGD:1600115
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
RGD:1600115
G Desi2 desumoylating isopeptidase 2 JBrowse link 13 96,111,800 96,156,693 RGD:1600115
RGD:1624291
G Mindy1 MINDY lysine 48 deubiquitinase 1 JBrowse link 2 196,458,229 196,470,133 RGD:1624291
RGD:13792537
G Mindy2 MINDY lysine 48 deubiquitinase 2 JBrowse link 8 77,029,346 77,089,208 RGD:1624291
RGD:13792537
G Mindy3 MINDY lysine 48 deubiquitinase 3 JBrowse link 17 79,720,534 79,798,470 RGD:1624291
RGD:13792537
G Mindy4 MINDY lysine 48 deubiquitinase 4 JBrowse link 4 85,427,741 85,536,264 RGD:13792537
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1600115
RGD:1624291
G Otud7b OTU deubiquitinase 7B JBrowse link 2 198,231,353 198,302,220 RGD:1624291
G Usp13 ubiquitin specific peptidase 13 JBrowse link 2 119,197,153 119,317,507 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:1600115
RGD:1624291
G Usp19 ubiquitin specific peptidase 19 JBrowse link 8 117,280,690 117,291,729 RGD:1624291
RGD:1600115
G Usp27x ubiquitin specific peptidase 27, X-linked JBrowse link X 15,987,964 15,991,149 RGD:1624291
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:1600115
RGD:1624291
G Usp9x ubiquitin specific peptidase 9, X-linked JBrowse link X 10,510,033 10,660,555 RGD:1624291
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1624291
Lys63-specific deubiquitinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:1624291
RGD:1600115
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:13792537
RGD:1624291
G Desi2 desumoylating isopeptidase 2 JBrowse link 13 96,111,800 96,156,693 RGD:1600115
RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1600115
RGD:13792537
RGD:1624291
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:1600115
G Stambp Stam binding protein JBrowse link 4 115,249,343 115,277,340 RGD:13792537
G Stambpl1 STAM binding protein-like 1 JBrowse link 1 252,490,125 252,536,113 RGD:13792537
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Usp27x ubiquitin specific peptidase 27, X-linked JBrowse link X 15,987,964 15,991,149 RGD:1624291
thiol-dependent ubiquitin-specific protease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07006871.1 RGD:13792537
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 9 82,393,619 82,400,537 RGD:13792537
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:1624291
RGD:13792537
RGD:1600115
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:1600115
RGD:13792537
RGD:1624291
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:1624291
RGD:13792537
RGD:1600115
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:1624291
RGD:13792537
G Eif3f eukaryotic translation initiation factor 3, subunit F JBrowse link 1 173,532,826 173,541,806 RGD:1624291
G Josd1 Josephin domain containing 1 JBrowse link 7 120,905,343 120,919,261 RGD:13792537
G Josd2 Josephin domain containing 2 JBrowse link 1 100,473,426 100,477,352 RGD:1624291
RGD:13792537
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
RGD:13792537
G LOC100911860 ubiquitin carboxyl-terminal hydrolase 40-like JBrowse link 9 91,037,406 91,100,490 RGD:13792537
G LOC108348050 ubiquitin carboxyl-terminal hydrolase 25-like JBrowse link 11 15,067,720 15,091,055 RGD:13792537
G LOC689730 similar to ubiquitin specific peptidase 17 (homolog) RGD:13792537
G Mindy1 MINDY lysine 48 deubiquitinase 1 JBrowse link 2 196,458,229 196,470,133 RGD:1600115
G Mindy2 MINDY lysine 48 deubiquitinase 2 JBrowse link 8 77,029,346 77,089,208 RGD:1600115
G Mysm1 myb-like, SWIRM and MPN domains 1 JBrowse link 5 113,902,115 113,939,083 RGD:1624291
RGD:13792537
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 JBrowse link 1 222,451,674 222,459,952 RGD:1600115
RGD:13792537
RGD:1624291
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 JBrowse link 6 127,282,445 127,301,086 RGD:1624291
RGD:13792537
G Otud1 OTU deubiquitinase 1 JBrowse link 17 86,406,643 86,410,670 RGD:1624291
RGD:13792537
G Otud3 OTU deubiquitinase 3 JBrowse link 5 157,346,286 157,368,450 RGD:1624291
RGD:13792537
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
G Otud5 OTU deubiquitinase 5 JBrowse link X 15,471,212 15,504,372 RGD:1600115
RGD:13792537
RGD:1624291
G Otud6a OTU deubiquitinase 6A JBrowse link X 70,256,299 70,257,746 RGD:1624291
RGD:13792537
G Otud6b OTU deubiquitinase 6B JBrowse link 5 28,333,019 28,350,093 RGD:13792537
G Otud7a OTU deubiquitinase 7A JBrowse link 1 124,311,873 124,655,437 RGD:1624291
RGD:1600115
G Otud7b OTU deubiquitinase 7B JBrowse link 2 198,231,353 198,302,220 RGD:1624291
RGD:13792537
RGD:1600115
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:1624291
RGD:13792537
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:13792537
G Senp3 SUMO specific peptidase 3 JBrowse link 10 56,277,609 56,286,867 RGD:1624291
G Stambp Stam binding protein JBrowse link 4 115,249,343 115,277,340 RGD:1624291
RGD:13792537
G Stambpl1 STAM binding protein-like 1 JBrowse link 1 252,490,125 252,536,113 RGD:13792537
G Tank TRAF family member-associated NFKB activator JBrowse link 3 47,439,007 47,515,706 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
RGD:13792537
G Uchl1 ubiquitin C-terminal hydrolase L1 JBrowse link 14 43,133,224 43,143,942 RGD:1624291
RGD:13792537
G Uchl3 ubiquitin C-terminal hydrolase L3 JBrowse link 15 86,153,624 86,198,127 RGD:1600115
RGD:13792537
RGD:1624291
G Uchl5 ubiquitin C-terminal hydrolase L5 JBrowse link 13 60,568,102 60,603,812 RGD:1624291
RGD:13792537
G Usp1 ubiquitin specific peptidase 1 JBrowse link 5 117,583,502 117,594,872 RGD:1600115
RGD:13792537
RGD:1624291
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1600115
RGD:13792537
RGD:1624291
G Usp11 ubiquitin specific peptidase 11 JBrowse link X 1,687,820 1,703,991 RGD:1624291
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:1624291
RGD:13792537
G Usp13 ubiquitin specific peptidase 13 JBrowse link 2 119,197,153 119,317,507 RGD:1624291
RGD:13792537
G Usp14 ubiquitin specific peptidase 14 JBrowse link 18 1,178,785 1,216,573 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:634484
RGD:1624291
RGD:1600115
G Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:1624291
RGD:1600115
G Usp18 ubiquitin specific peptidase 18 JBrowse link 4 153,812,312 153,834,374 RGD:13792537
G Usp19 ubiquitin specific peptidase 19 JBrowse link 8 117,280,690 117,291,729 RGD:1600115
RGD:1624291
G Usp2 ubiquitin specific peptidase 2 JBrowse link 8 48,403,985 48,432,525 RGD:634247
RGD:1624291
G Usp20 ubiquitin specific peptidase 20 JBrowse link 3 9,822,586 9,856,057 RGD:1600115
G Usp21 ubiquitin specific peptidase 21 JBrowse link 13 89,655,016 89,661,150 RGD:1600115
RGD:1624291
G Usp22 ubiquitin specific peptidase 22 JBrowse link 10 47,429,201 47,453,298 RGD:1624291
G Usp24 ubiquitin specific peptidase 24 JBrowse link 5 125,896,725 126,030,411 RGD:13792537
G Usp25 ubiquitin specific peptidase 25 JBrowse link 11 15,436,080 15,558,646 RGD:1624291
RGD:13792537
G Usp26 ubiquitin specific peptidase 26 JBrowse link X 139,030,239 139,079,336 RGD:13792537
G Usp27x ubiquitin specific peptidase 27, X-linked JBrowse link X 15,987,964 15,991,149 RGD:1624291
G Usp28 ubiquitin specific peptidase 28 JBrowse link 8 53,295,188 53,355,572 RGD:1600115
RGD:13792537
RGD:1624291
G Usp29 ubiquitin specific peptidase 29 JBrowse link 1 69,988,673 70,042,015 RGD:13792537
G Usp3 ubiquitin specific peptidase 3 JBrowse link 8 72,207,970 72,284,871 RGD:1624291
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:1624291
RGD:13792537
G Usp31 ubiquitin specific peptidase 31 JBrowse link 1 191,615,146 191,651,628 RGD:1624291
G Usp32 ubiquitin specific peptidase 32 JBrowse link 10 72,300,173 72,474,574 RGD:1624291
RGD:13792537
G Usp33 ubiquitin specific peptidase 33 JBrowse link 2 257,567,179 257,602,817 RGD:1624291
G Usp34 ubiquitin specific peptidase 34 JBrowse link 14 108,060,653 108,264,706 RGD:1624291
RGD:13792537
G Usp35 ubiquitin specific peptidase 35 JBrowse link 1 162,283,866 162,307,610 RGD:1624291
RGD:13792537
G Usp36 ubiquitin specific peptidase 36 JBrowse link 10 107,292,828 107,324,355 RGD:1624291
RGD:13792537
G Usp37 ubiquitin specific peptidase 37 JBrowse link 9 81,717,626 81,818,421 RGD:1624291
RGD:13792537
G Usp38 ubiquitin specific peptidase 38 JBrowse link 19 30,668,258 30,699,852 RGD:1624291
RGD:13792537
G Usp4 ubiquitin specific peptidase 4 JBrowse link 8 117,126,692 117,171,012 RGD:1600115
RGD:1624291
G Usp40 ubiquitin specific peptidase 40 JBrowse link 9 95,072,096 95,143,092 RGD:13792537
G Usp42 ubiquitin specific peptidase 42 JBrowse link 12 12,840,131 12,878,207 RGD:1624291
RGD:13792537
G Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:1624291
G Usp45 ubiquitin specific peptidase 45 JBrowse link 5 35,916,763 35,984,525 RGD:1624291
G Usp46 ubiquitin specific peptidase 46 JBrowse link 14 36,687,134 36,755,360 RGD:1624291
RGD:13792537
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:1624291
RGD:13792537
G Usp48 ubiquitin specific peptidase 48 JBrowse link 5 155,935,102 156,002,722 RGD:1600115
RGD:13792537
G Usp49 ubiquitin specific peptidase 49 JBrowse link 9 15,314,875 15,375,365 RGD:1624291
G Usp5 ubiquitin specific peptidase 5 JBrowse link 4 157,332,735 157,347,803 RGD:1624291
RGD:13792537
G Usp50 ubiquitin specific peptidase 50 JBrowse link 3 119,225,055 119,247,442 RGD:13792537
G Usp51 ubiquitin specific peptidase 51 JBrowse link X 19,268,352 19,273,753 RGD:1624291
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:2316130
RGD:1624291
RGD:13792537
RGD:1600115
G Usp8 ubiquitin specific peptidase 8 JBrowse link 3 119,173,818 119,222,499 RGD:1624291
RGD:13792537
G Usp9x ubiquitin specific peptidase 9, X-linked JBrowse link X 10,510,033 10,660,555 RGD:13792537
G Usp9y ubiquitin specific peptidase 9, Y-linked JBrowse link Y 1,260,512 1,403,417 RGD:13792537
G Vcpip1 valosin containing protein interacting protein 1 JBrowse link 5 9,231,180 9,257,821 RGD:1302353
RGD:13792537
RGD:1624291
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1600115
RGD:13792537
RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
G Zranb1 zinc finger RANBP2-type containing 1 JBrowse link 1 204,938,444 205,000,163 RGD:1624291
RGD:13792537
thiol-dependent ubiquitinyl hydrolase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07013202.1 RGD:1600115
G Atxn3 ataxin 3 JBrowse link 6 125,817,420 125,853,461 RGD:1624291
RGD:1600115
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:1600115
RGD:1624291
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 JBrowse link 9 9,863,380 9,865,920 RGD:1600115
RGD:13792537
RGD:1624291
G Desi2 desumoylating isopeptidase 2 JBrowse link 13 96,111,800 96,156,693 RGD:1600115
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Mysm1 myb-like, SWIRM and MPN domains 1 JBrowse link 5 113,902,115 113,939,083 RGD:1624291
G Otud6b OTU deubiquitinase 6B JBrowse link 5 28,333,019 28,350,093 RGD:1624291
G Otud7b OTU deubiquitinase 7B JBrowse link 2 198,231,353 198,302,220 RGD:1624291
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:1624291
G RGD1561481 similar to ubiquitin specific protease 12 JBrowse link 16 70,081,041 70,085,061 RGD:1600115
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Usp1 ubiquitin specific peptidase 1 JBrowse link 5 117,583,502 117,594,872 RGD:1624291
RGD:1600115
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1600115
RGD:1624291
G Usp12 ubiquitin specific peptidase 12 JBrowse link 12 10,037,686 10,087,685 RGD:1624291
G Usp13 ubiquitin specific peptidase 13 JBrowse link 2 119,197,153 119,317,507 RGD:1624291
G Usp14 ubiquitin specific peptidase 14 JBrowse link 18 1,178,785 1,216,573 RGD:1624291
G Usp15 ubiquitin specific peptidase 15 JBrowse link 7 66,595,707 66,687,707 RGD:634484
RGD:1600115
RGD:1624291
G Usp16 ubiquitin specific peptidase 16 JBrowse link 11 27,101,213 27,130,345 RGD:1624291
RGD:1600115
G Usp19 ubiquitin specific peptidase 19 JBrowse link 8 117,280,690 117,291,729 RGD:1600115
G Usp20 ubiquitin specific peptidase 20 JBrowse link 3 9,822,586 9,856,057 RGD:1624291
G Usp21 ubiquitin specific peptidase 21 JBrowse link 13 89,655,016 89,661,150 RGD:1624291
RGD:1600115
G Usp28 ubiquitin specific peptidase 28 JBrowse link 8 53,295,188 53,355,572 RGD:1600115
RGD:1624291
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:1624291
RGD:1600115
G Usp33 ubiquitin specific peptidase 33 JBrowse link 2 257,567,179 257,602,817 RGD:1624291
G Usp34 ubiquitin specific peptidase 34 JBrowse link 14 108,060,653 108,264,706 RGD:1624291
G Usp39 ubiquitin specific peptidase 39 JBrowse link 4 100,181,408 100,211,425 RGD:1600115
G Usp43 ubiquitin specific peptidase 43 JBrowse link 10 54,406,980 54,467,956 RGD:1600115
G Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:1624291
G Usp46 ubiquitin specific peptidase 46 JBrowse link 14 36,687,134 36,755,360 RGD:1600115
RGD:1624291
G Usp49 ubiquitin specific peptidase 49 JBrowse link 9 15,314,875 15,375,365 RGD:1624291
G Usp53 ubiquitin specific peptidase 53 JBrowse link 2 227,098,795 227,160,385 RGD:1624291
G Usp54 ubiquitin specific peptidase 54 JBrowse link 15 4,091,834 4,190,408 RGD:1600115
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:1624291
G Usp9x ubiquitin specific peptidase 9, X-linked JBrowse link X 10,510,033 10,660,555 RGD:1624291
G Usp9y ubiquitin specific peptidase 9, Y-linked JBrowse link Y 1,260,512 1,403,417 RGD:1600115
G Zranb1 zinc finger RANBP2-type containing 1 JBrowse link 1 204,938,444 205,000,163 RGD:1624291
G Zup1 zinc finger containing ubiquitin peptidase 1 JBrowse link 20 32,471,670 32,501,693 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19528
    catalytic activity 6039
      catalytic activity, acting on a protein 2282
        ubiquitinyl hydrolase activity 98
          Lys48-specific deubiquitinase activity 17
          Lys63-specific deubiquitinase activity 10
          thiol-dependent ubiquitinyl hydrolase activity + 95
          ubiquitinyl hydrolase activity, acting on linear ubiquitin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.