ONTOLOGY REPORT - ANNOTATIONS


Term:cell-cell fusion
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Accession:GO:0140253 term browser browse the term
Definition:A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
Comment:Created new term, see https://github.com/geneontology/go-ontology/issues/15939.
Synonyms:broad_synonym: cell fusion


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cell-cell fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vash2 vasohibin 2 JBrowse link 13 109,521,190 109,552,607 RGD:1624291
macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:2289375
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb3 adhesion G protein-coupled receptor B3 JBrowse link 9 31,280,623 32,022,535 RGD:1624291
RGD:1600115
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1298731
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:1298731
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B JBrowse link 1 85,112,819 85,120,840 RGD:1624291
RGD:1600115
G Fer1l5 fer-1-like family member 5 JBrowse link 9 42,943,362 42,998,126 RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1600115
RGD:1624291
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:1600115
G Myof myoferlin JBrowse link 1 256,585,410 256,734,727 RGD:1600115
G Neo1 neogenin 1 JBrowse link 8 63,649,871 63,756,394 RGD:1624291
G Nphs1 NPHS1 adhesion molecule, nephrin JBrowse link 1 88,922,346 88,950,560 RGD:1600115
RGD:1624291
G Pitx2 paired-like homeodomain 2 JBrowse link 2 233,602,732 233,621,059 RGD:1624291
G Plekho1 pleckstrin homology domain containing O1 JBrowse link 2 198,112,104 198,120,202 RGD:1624291
RGD:1600115
G Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 JBrowse link 3 45,683,773 45,917,687 RGD:1624291
RGD:1600115
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
RGD:1600115
myoblast fusion involved in skeletal muscle regeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:1600115
RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1624291
G Ptgfrn prostaglandin F2 receptor inhibitor JBrowse link 2 203,423,143 203,494,391 RGD:1600115
RGD:1624291
negative regulation of macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1624291
negative regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:1624291
RGD:1600115
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:1624291
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:1624291
negative regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:1624291
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1624291
RGD:1600115
osteoclast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd109 CD109 molecule JBrowse link 8 85,951,420 86,065,411 RGD:1624291
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Sbno2 strawberry notch homolog 2 JBrowse link 7 12,471,805 12,515,700 RGD:1624291
RGD:1600115
G Sh3pxd2a SH3 and PX domains 2A JBrowse link 1 267,039,654 267,245,868 RGD:1624291
RGD:1600115
G Tcta T-cell leukemia translocation altered JBrowse link 8 117,079,094 117,082,338 RGD:1624291
RGD:13792537
positive regulation of macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam9 ADAM metallopeptidase domain 9 JBrowse link 16 71,810,377 71,887,926 RGD:1624291
RGD:1600115
G Dcstamp dendrocyte expressed seven transmembrane protein JBrowse link 7 78,642,016 78,651,763 RGD:1624291
G Ocstamp osteoclast stimulatory transmembrane protein JBrowse link 3 162,073,573 162,080,487 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:1600115
RGD:1624291
positive regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:13792659
G Cd53 Cd53 molecule JBrowse link 2 209,489,279 209,537,098 RGD:1624291
RGD:1600115
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:1624291
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:1624291
RGD:1600115
G Ehd1 EH-domain containing 1 JBrowse link 1 221,644,867 221,667,242 RGD:1624291
RGD:1600115
G Ehd2 EH-domain containing 2 JBrowse link 1 77,847,599 77,865,870 RGD:1624291
RGD:1600115
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
RGD:1600115
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:1624291
RGD:1600115
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1624291
RGD:1600115
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1600115
RGD:1624291
G Myf5 myogenic factor 5 JBrowse link 7 49,729,533 49,732,974 RGD:13792537
G Myf6 myogenic factor 6 JBrowse link 7 49,739,643 49,741,490 RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:13792537
RGD:1600115
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:13792537
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1624291
RGD:1600115
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scgb3a1 secretoglobin, family 3A, member 1 JBrowse link 10 35,133,561 35,134,868 RGD:1624291
RGD:13792537
G Tnfsf14 TNF superfamily member 14 JBrowse link 9 9,761,363 9,765,461 RGD:1624291
RGD:1600115
positive regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk1 calcium/calmodulin-dependent protein kinase I JBrowse link 4 145,289,300 145,300,146 RGD:1624291
RGD:1600115
G Gcm1 glial cells missing transcription factor 1 JBrowse link 8 85,355,766 85,369,002 RGD:1624291
RGD:1600115
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1624291
RGD:1600115
regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:1600115
syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ervfrd-1 endogenous retrovirus group FRD member 1, envelope JBrowse link 12 25,161,130 25,168,182 RGD:1624291
RGD:1600115
G Synb syncytin b JBrowse link 15 51,174,986 51,222,929 RGD:1624291
G Vash2 vasohibin 2 JBrowse link 13 109,521,190 109,552,607 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 17896
    cellular process 16040
      cell-cell fusion 65
        conjugation with cellular fusion + 0
        parasexual conjugation with cellular fusion 0
        syncytium formation by plasma membrane fusion + 65
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.