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ONTOLOGY REPORT - ANNOTATIONS


Term:integrated stress response signaling
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Accession:GO:0140467 term browser browse the term
Definition:The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
Synonyms:related_synonym: ISR
 xref: Wikipedia:Integrated_stress_response


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integrated stress response signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO
ISS
(PMID:32132707)
(MGI:MGI:3798818|PMID:12667446)
GO_REF:0000024
RGD
UniProt
PMID:12667446, PMID:32132707 GO_REF:0000024, MGI:MGI:3798818 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 ISO
ISS
(PMID:32132706), (PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132706, PMID:32132707 GO_REF:0000024 NCBI chr18:31,396,897...31,409,914
Ensembl chr18:31,396,922...31,409,907
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO
ISS
(PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132707 GO_REF:0000024 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Oma1 OMA1 zinc metallopeptidase ISO
ISS
(PMID:32132706), (PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132706, PMID:32132707 GO_REF:0000024 NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475
JBrowse link
HRI-mediated signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO
ISS
(PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132707 GO_REF:0000024 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 ISO
ISS
(PMID:32132706), (PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132706, PMID:32132707 GO_REF:0000024 NCBI chr18:31,396,897...31,409,914
Ensembl chr18:31,396,922...31,409,907
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO
ISS
(PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132707 GO_REF:0000024 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Oma1 OMA1 zinc metallopeptidase ISO
ISS
(PMID:32132706), (PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132706, PMID:32132707 GO_REF:0000024 NCBI chr 5:122,847,624...122,900,475
Ensembl chr 5:122,847,645...122,900,475
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213)
UniProtKB:O55033 (MGI:MGI:5613478|PMID:14676213)
RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO UniProtKB:Q99M51 (MGI:MGI:5613478|PMID:14676213) RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO (PMID:21216966)
(MGI:MGI:5619464|PMID:21216966)
RGD PMID:21216966 MGI:MGI:5619464 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:3722921|PMID:14729979), (MGI:MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:12667446, PMID:14729979 GO_REF:0000024, MGI:MGI:3722921, MGI:MGI:3798818 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:MGI:3722921 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO (MGI:MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:MGI:2677605 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:MGI:4456438 (MGI:MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO
ISS
(MGI:MGI:5648772|PMID:26015568)
GO_REF:0000024
RGD
UniProt
PMID:26015568 GO_REF:0000024, MGI:MGI:5648772 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO (MGI:MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:MGI:5619464 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Tmem33 transmembrane protein 33 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26268696)
Ensembl
UniProt
RGD
PMID:26268696 GO_REF:0000024, GO_REF:0000107 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to stress 4059
        cellular response to stress 1992
          integrated stress response signaling 14
            GCN2-mediated signaling 0
            HRI-mediated signaling 4
            PERK-mediated unfolded protein response + 11
            PKR-mediated signaling 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.