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ONTOLOGY REPORT - ANNOTATIONS


Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:A series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway


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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 ISO (PMID:9396766) RGD PMID:9396766 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Gsdme gasdermin E ISO (PMID:31953257), (PMID:32188940) RGD PMID:31953257, PMID:32188940 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Gzma granzyme A ISO (PMID:32299851) RGD PMID:32299851 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Gzmb granzyme B ISO
ISS
MGI:MGI:1857156 (MGI:MGI:3531039|PMID:15454490), (MGI:MGI:3665503|PMID:16618603)
GO_REF:0000024
(PMID:31953257), (PMID:32188940)
RGD
UniProt
PMID:15454490, PMID:16618603, PMID:31953257, PMID:32188940 GO_REF:0000024, MGI:MGI:3531039, MGI:MGI:3665503 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Gzmbl2 Granzyme B-like 2 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr15:36,469,318...36,472,393
Ensembl chr15:35,413,793...35,417,316
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 ISO (PMID:23632890) RGD PMID:23632890 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Srgn serglycin ISO
ISS
(PMID:11911826)
GO_REF:0000024
RGD
UniProt
PMID:11911826 GO_REF:0000024 NCBI chr20:32,120,317...32,158,071
Ensembl chr20:32,120,320...32,139,789
JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07018028.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr15:36,416,053...36,417,868 JBrowse link
G Gzmb granzyme B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Gzmbl1 Granszyme B-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:123,015,024...123,023,509
Ensembl chr  X:123,015,480...123,018,444
JBrowse link
G Gzmbl2 Granzyme B-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:36,469,318...36,472,393
Ensembl chr15:35,413,793...35,417,316
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Gzmbl3 Granzyme B-like 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:36,111,884...36,114,917
Ensembl chr15:36,111,986...36,114,752
JBrowse link
G Gzmc granzyme C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,392,158...35,394,787
Ensembl chr15:35,392,162...35,394,792
JBrowse link
G Gzmf granzyme F IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,182,405...35,195,725
Ensembl chr15:35,184,364...35,195,725
JBrowse link
G Gzmn granzyme N IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,129,622...35,160,290
Ensembl chr15:35,150,851...35,153,804
Ensembl chr15:35,150,851...35,153,804
JBrowse link
G LOC100910060 granzyme G-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,262,905...35,264,965
Ensembl chr15:35,263,718...35,264,841
JBrowse link
G LOC102553861 granzyme-like protein 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:36,354,952...36,361,083 JBrowse link
G LOC691670 similar to natural killer cell protease 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,163,014...35,166,264
Ensembl chr15:35,163,388...35,166,211
JBrowse link
G LOC691695 similar to granzyme C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:36,448,970...36,451,721
Ensembl chr15:36,448,971...36,451,720
JBrowse link
G LOC691720 similar to Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:36,415,938...36,417,880 JBrowse link
G Ube4b ubiquitination factor E4B ISO (PMID:11802788) RGD PMID:11802788 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    signaling 7583
      signal transduction 7011
        granzyme-mediated programmed cell death signaling pathway 19
          granzyme-mediated apoptotic signaling pathway 14
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            granzyme-mediated programmed cell death signaling pathway 19
              granzyme-mediated apoptotic signaling pathway 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.