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ONTOLOGY REPORT - ANNOTATIONS


Term:transport across blood-brain barrier
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Accession:GO:0150104 term browser browse the term
Definition:The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.
Synonyms:exact_synonym: transport across BBB


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transport across blood-brain barrier term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEA
ISO
GO_REF:0000107
(PMID:23973487)
Ensembl
RGD
PMID:23973487 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Lrp1 LDL receptor related protein 1 ISO (MGI:MGI:5439721|PMID:20630619), (MGI:MGI:5754651|PMID:26619118) RGD PMID:20630619, PMID:26619118 MGI:MGI:5439721, MGI:MGI:5754651 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Slc16a2 solute carrier family 16 member 2 ISO
IEA
(PMID:28526555)
GO_REF:0000107
RGD
Ensembl
PMID:28526555 GO_REF:0000107 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc1a5 solute carrier family 1 member 5 ISO (MGI:MGI:6393124|PMID:14622120) RGD PMID:14622120 MGI:MGI:6393124 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a5 solute carrier family 22 member 5 ISO (MGI:MGI:6437032|PMID:14595704) RGD PMID:14595704 MGI:MGI:6437032 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO UniProtKB:P11169|UniProtKB:P13866 (PMID:1714544), (PMID:23975336), (PMID:28993322) RGD PMID:1714544, PMID:23975336, PMID:28993322 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a3 solute carrier family 2 member 3 ISO UniProtKB:P11166|UniProtKB:P13866 (PMID:23975336) RGD PMID:23975336 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc5a1 solute carrier family 5 member 1 ISO UniProtKB:P11166|UniProtKB:P11169 (PMID:23975336) RGD PMID:23975336 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Slc5a6 solute carrier family 5 member 6 ISO (PMID:25809983) RGD PMID:25809983 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
JBrowse link
lipid transport across blood-brain barrier term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule ISO (PMID:21395585) RGD PMID:21395585 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Fabp5 fatty acid binding protein 5 ISO (PMID:21395585) RGD PMID:21395585 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A ISO (MGI:MGI:5571501|PMID:24828044)
(PMID:26005865)
RGD PMID:24828044, PMID:26005865 MGI:MGI:5571501 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Slc27a1 solute carrier family 27 member 1 ISO
IEA
(PMID:21395585)
GO_REF:0000107
RGD
Ensembl
PMID:21395585 GO_REF:0000107 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Slc27a4 solute carrier family 27 member 4 ISO (PMID:21395585) RGD PMID:21395585 NCBI chr 3:8,363,937...8,376,858
Ensembl chr 3:8,363,937...8,376,858
JBrowse link
negative regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO (PMID:24345162) RGD PMID:24345162 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
positive regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
IEA
(PMID:24345162)
GO_REF:0000107
RGD
Ensembl
PMID:24345162 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
xenobiotic transport across blood-brain barrier term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP
ISO
(MGI:MGI:6369882|PMID:28587984) RGD PMID:28587984, PMID:25053619 MGI:MGI:6369882, RGD:11252095 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 IMP
IGI
PMID:12663688
PMID:17437408
ARUK-UCL PMID:12663688, PMID:17437408 RGD:704399, RGD:14929203 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO
IC
(PMID:12958161)
PMID:15773906
RGD PMID:12958161, PMID:15773906 RGD:14929200 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Slc22a1 solute carrier family 22 member 1 NAS PMID:20477935 ARUK-UCL PMID:20477935 RGD:30309941 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 NAS PMID:20477935 ARUK-UCL PMID:20477935 RGD:30309941 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    localization 6486
      establishment of localization 4918
        transport 4774
          vascular transport 21
            transport across blood-brain barrier 20
              copper ion transport across blood-brain barrier 0
              lipid transport across blood-brain barrier + 6
              negative regulation of transport across blood-brain barrier + 1
              positive regulation of transport across blood-brain barrier + 1
              regulation of transport across blood-brain barrier + 1
              xenobiotic transport across blood-brain barrier 5
Path 2
Term Annotations click to browse term
  biological_process 20014
    multicellular organismal process 9055
      system process 3445
        circulatory system process 578
          vascular process in circulatory system 247
            vascular transport 21
              transport across blood-brain barrier 20
                copper ion transport across blood-brain barrier 0
                lipid transport across blood-brain barrier + 6
                negative regulation of transport across blood-brain barrier + 1
                positive regulation of transport across blood-brain barrier + 1
                regulation of transport across blood-brain barrier + 1
                xenobiotic transport across blood-brain barrier 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.