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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of nodal signaling pathway
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Accession:GO:1900108 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway.
Synonyms:exact_synonym: down-regulation of nodal signaling;   down-regulation of nodal signaling pathway;   downregulation of nodal signaling;   downregulation of nodal signaling pathway;   negative regulation of nodal signaling;   negative regulation of nodal signalling pathway
 narrow_synonym: inhibition of nodal signaling;   inhibition of nodal signaling pathway


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negative regulation of nodal signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO
IBA
(MGI:MGI:3809364|PMID:18716284), (MGI:MGI:5437437|PMID:17197390)
PMID:21873635
RGD PMID:17197390, PMID:18716284, PMID:21873635 MGI:MGI:3809364, MGI:MGI:5437437, RGD:13792537 NCBI chr 1:56,159,435...56,169,443
Ensembl chr 1:56,159,426...56,168,351
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Lefty1 left right determination factor 1 ISO (MGI:MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:MGI:3042530 NCBI chr13:99,212,778...99,217,786
Ensembl chr13:99,214,389...99,217,786
JBrowse link
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      signal transduction 7011
        negative regulation of signal transduction 1235
          negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 129
            negative regulation of activin receptor signaling pathway 13
              negative regulation of nodal signaling pathway 4
                negative regulation of nodal signaling pathway involved in determination of left/right asymmetry + 2
                sequestering of nodal from receptor via nodal binding 1
Path 2
Term Annotations click to browse term
  biological_process 20028
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            cell surface receptor signaling pathway 2761
              enzyme linked receptor protein signaling pathway 969
                transmembrane receptor protein serine/threonine kinase signaling pathway 387
                  regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 257
                    regulation of activin receptor signaling pathway 28
                      negative regulation of activin receptor signaling pathway 13
                        negative regulation of nodal signaling pathway 4
                          negative regulation of nodal signaling pathway involved in determination of left/right asymmetry + 2
                          sequestering of nodal from receptor via nodal binding 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.