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ONTOLOGY REPORT - ANNOTATIONS


Term:extracellular negative regulation of signal transduction
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Accession:GO:1900116 term browser browse the term
Definition:Any negative regulation of signal transduction that takes place in extracellular region.
Synonyms:exact_synonym: down regulation of signal transduction in extracellular region;   downregulation of signal transduction in extracellular region;   negative regulation of signaling pathway in extracellular region;   negative regulation of signalling pathway in extracellular region
 narrow_synonym: extracellular inhibition of signaling pathway;   inhibition of signal transduction in extracellular region


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extracellular negative regulation of signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp653 zinc finger protein 653 ISO (PMID:12920234) RGD PMID:12920234 NCBI chr 8:23,066,576...23,085,502
Ensembl chr 8:23,066,576...23,084,879
JBrowse link
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Grem2 gremlin 2, DAN family BMP antagonist ISO
IBA
(MGI:MGI:5507937|PMID:23063586)
PMID:21873635
RGD PMID:23063586, PMID:21873635 MGI:MGI:5507937, RGD:13792537 NCBI chr13:92,894,431...92,988,137
Ensembl chr13:92,894,431...92,988,137
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist ISO
IBA
IEA
(PMID:23063586)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:23063586, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link
sequestering of BMP in extracellular matrix term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist ISO
IBA
(PMID:9660951)
PMID:21873635
(MGI:MGI:1858315|PMID:10748465)
RGD PMID:9660951, PMID:10748465, PMID:21873635 MGI:MGI:1858315, RGD:13792537 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Fbn1 fibrillin 1 ISO (MGI:MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:MGI:4836762 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist ISO
IEA
(MGI:MGI:1203284|PMID:9660951)
GO_REF:0000107
RGD
Ensembl
PMID:9660951 GO_REF:0000107, MGI:MGI:1203284 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link
sequestering of extracellular ligand from receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule ISO (PMID:23086448) RGD PMID:23086448 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 ISO (MGI:MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
sequestering of TGFbeta in extracellular matrix term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbn1 fibrillin 1 ISO (MGI:MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:MGI:4836762 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbn2 fibrillin 2 ISO (MGI:MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:MGI:4836762 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISS
ISO
IEA
GO_REF:0000024
(PMID:2022183), (PMID:8617200)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:2022183, PMID:8617200 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
G Nrros negative regulator of reactive oxygen species ISS
ISO
GO_REF:0000024
(MGI:MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024, MGI:MGI:6192878 NCBI chr11:71,872,728...71,889,897
Ensembl chr11:71,872,830...71,889,887
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        negative regulation of signal transduction 1243
          extracellular negative regulation of signal transduction 11
            sequestering of extracellular ligand from receptor + 10
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            regulation of signal transduction 2997
              extracellular regulation of signal transduction 11
                extracellular negative regulation of signal transduction 11
                  sequestering of extracellular ligand from receptor + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.