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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of ERBB signaling pathway
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Accession:GO:1901186 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: activation of EGF receptor family signaling pathway;   activation of ERBB signalling pathway;   activation of ErbB signaling;   positive regulation of EGF receptor family signaling pathway;   positive regulation of ERBB signalling pathway;   positive regulation of ErbB signaling;   up regulation of EGF receptor family signaling pathway;   up regulation of ERBB signaling pathway;   up regulation of ERBB signalling pathway;   up regulation of ErbB signaling;   upregulation of EGF receptor family signaling pathway;   upregulation of ERBB signaling pathway;   upregulation of ERBB signalling pathway;   upregulation of ErbB signaling
 narrow_synonym: activation of ERBB signaling pathway
 related_synonym: activation of EGFR family signaling pathway;   positive regulation of EGFR family signaling pathway;   up regulation of EGFR family signaling pathway;   upregulation of EGFR family signaling pathway


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positive regulation of ERBB signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO (MGI:MGI:3701380|PMID:17336907) RGD PMID:17336907 MGI:MGI:3701380 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afap1l2 actin filament associated protein 1-like 2 ISO
IBA
(PMID:17412687)
PMID:21873635
RGD PMID:17412687, PMID:21873635 RGD:13792537 NCBI chr 1:277,730,760...277,827,299
Ensembl chr 1:277,730,760...277,827,269
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO (PMID:25666625) RGD PMID:25666625 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agt angiotensinogen ISO (PMID:15652490) RGD PMID:15652490 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Ccdc88a coiled coil domain containing 88A ISO (PMID:20462955) RGD PMID:20462955 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 ISO (PMID:20878056) RGD PMID:20878056 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805
JBrowse link
G Dgkd diacylglycerol kinase, delta ISO
IEA
(MGI:MGI:3691361|PMID:17021016)
GO_REF:0000107
RGD
Ensembl
PMID:17021016 GO_REF:0000107, MGI:MGI:3691361 NCBI chr 9:94,980,328...95,071,531
Ensembl chr 9:94,980,409...95,069,714
JBrowse link
G Esr1 estrogen receptor 1 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:17928626 RGD:5128669 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Faslg Fas ligand IMP RGD PMID:18471522 RGD:2315731 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP
ISO
IEA
(MGI:MGI:5141337|PMID:21673097)
(PMID:15705806)
GO_REF:0000107
RGD
Ensembl
PMID:15705806, PMID:21673097, PMID:20445128 GO_REF:0000107, MGI:MGI:5141337, RGD:4892084 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hap1 huntingtin-associated protein 1 IMP PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Hip1 huntingtin interacting protein 1 ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:24,180,795...24,315,373
Ensembl chr12:24,180,937...24,315,373
JBrowse link
G Hip1r huntingtin interacting protein 1 related ISO (PMID:14732715) RGD PMID:14732715 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Neu3 neuraminidase 3 ISO
IEA
(PMID:17334392)
GO_REF:0000107
RGD
Ensembl
PMID:17334392 GO_REF:0000107 NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651
JBrowse link
G Pde6g phosphodiesterase 6G ISO
IBA
(MGI:MGI:2156093|PMID:11502744)
PMID:21873635
RGD PMID:11502744, PMID:21873635 MGI:MGI:2156093, RGD:13792537 NCBI chr10:109,620,499...109,625,214
Ensembl chr10:109,620,980...109,622,745
JBrowse link
G Pde6h phosphodiesterase 6H ISO
IBA
(MGI:MGI:2156093|PMID:11502744)
PMID:21873635
RGD PMID:11502744, PMID:21873635 MGI:MGI:2156093, RGD:13792537 NCBI chr 4:170,947,723...170,963,046
Ensembl chr 4:170,958,196...170,963,046
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO
IEA
(PMID:22984561)
GO_REF:0000107
RGD
Ensembl
PMID:22984561 GO_REF:0000107 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Shkbp1 Sh3kbp1 binding protein 1 ISO
IBA
ISS
(MGI:MGI:5700492|PMID:21830225)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21830225, PMID:21873635 GO_REF:0000024, MGI:MGI:5700492, RGD:13792537 NCBI chr 1:84,154,703...84,168,074
Ensembl chr 1:84,154,703...84,168,074
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP RGD PMID:8577724 RGD:1581110 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
positive regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:17655843), (PMID:18483258)
GO_REF:0000107
RGD
Ensembl
PMID:17655843, PMID:18483258 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adora1 adenosine A1 receptor IMP RGD PMID:19574994 RGD:2317913 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Areg amphiregulin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Egf epidermal growth factor ISO (PMID:15611079), (PMID:20353436), (PMID:22732145) RGD PMID:15611079, PMID:20353436, PMID:22732145 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Epgn epithelial mitogen ISO
IBA
ISS
(PMID:15611079)
PMID:21873635
GO_REF:0000024
(MGI:MGI:1934957|PMID:11278323)
RGD
HGNC
PMID:11278323, PMID:15611079, PMID:21873635 GO_REF:0000024, MGI:MGI:1934957, RGD:13792537 NCBI chr14:18,627,103...18,635,135
Ensembl chr14:18,626,644...18,634,309
JBrowse link
G Ereg epiregulin IDA
IBA
PMID:9990076
PMID:21873635
UniProt
GO_Central
PMID:9990076, PMID:21873635 RGD:632743, RGD:13792537 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO (PMID:20208556) RGD PMID:20208556 NCBI chr 2:184,230,191...184,309,805
Ensembl chr 2:184,231,260...184,309,664
JBrowse link
G Hbegf heparin-binding EGF-like growth factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO MGI:MGI:2152037 (MGI:MGI:2149168|PMID:11481456) RGD PMID:11481456 MGI:MGI:2149168 NCBI chr 1:266,953,006...267,038,879
Ensembl chr 1:266,952,561...267,038,883
JBrowse link
G Tgfa transforming growth factor alpha ISO
IBA
ISS
(PMID:11278323)
PMID:21873635
GO_REF:0000024
RGD
HGNC
PMID:11278323, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtn4 reticulon 4 IEA
ISO
GO_REF:0000107
(PMID:27353365)
Ensembl
RGD
PMID:27353365 GO_REF:0000107 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        positive regulation of signal transduction 1682
          positive regulation of ERBB signaling pathway 36
            positive regulation of ERBB3 signaling pathway 1
            positive regulation of epidermal growth factor receptor signaling pathway + 34
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            cell surface receptor signaling pathway 2782
              enzyme linked receptor protein signaling pathway 963
                transmembrane receptor protein tyrosine kinase signaling pathway 605
                  ERBB signaling pathway 116
                    regulation of ERBB signaling pathway 78
                      positive regulation of ERBB signaling pathway 36
                        positive regulation of ERBB3 signaling pathway 1
                        positive regulation of epidermal growth factor receptor signaling pathway + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.