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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of NIK/NF-kappaB signaling
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Accession:GO:1901222 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling.
Synonyms:narrow_synonym: NF-KB import into nucleus;   NF-kappaB import into nucleus;   regulation of NF-kappaB import into nucleus;   regulation of p52-dependent NF-kappaB signaling
 broad_synonym: regulation of non-canonical NF-KB signaling;   regulation of noncanonical NF-kappaB signaling;   regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway
 related_synonym: regulation of NIK/NF-kappaB cascade
 alt_id: GO:0042345;   GO:0042348


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regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akip1 A-kinase interacting protein 1 JBrowse link 1 174,330,628 174,339,494 RGD:1600115
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:1624291
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:1624291
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:1624291
G Eda ectodysplasin-A JBrowse link X 69,730,123 70,222,693 RGD:1624291
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:1624291
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link 3 176,881,881 176,888,230 RGD:1624291
RGD:13792537
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1624291
RGD:1600115
G Prdx1 peroxiredoxin 1 JBrowse link 5 135,536,413 135,551,986 RGD:1624291
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:1624291
RGD:13792537
G Rassf2 Ras association domain family member 2 JBrowse link 3 124,574,088 124,610,267 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:1624291
G Trim6 tripartite motif containing 6 JBrowse link 1 169,410,084 169,423,305 RGD:1624291
activation of NF-kappaB-inducing kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1624291
G Card10 caspase recruitment domain family, member 10 JBrowse link 7 119,998,639 120,028,632 RGD:1624291
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:1624291
RGD:1600115
G Cops8 COP9 signalosome subunit 8 JBrowse link 9 97,772,224 97,782,055 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tnfsf15 TNF superfamily member 15 JBrowse link 5 79,553,935 79,569,974 RGD:1624291
RGD:1600115
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
G Traf4 Tnf receptor associated factor 4 JBrowse link 10 65,418,688 65,424,802 RGD:1600115
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Zfp91 zinc finger protein 91 JBrowse link 1 229,602,499 229,640,906 RGD:1624291
negative regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg3 adhesion G protein-coupled receptor G3 JBrowse link 19 10,392,001 10,422,606 RGD:1624291
G Adipor1 adiponectin receptor 1 JBrowse link 13 51,240,470 51,260,233 RGD:1624291
G C1qtnf3 C1q and TNF related 3 JBrowse link 2 60,920,160 60,942,586 RGD:1624291
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:13792556
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1600115
RGD:1624291
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1600115
RGD:1624291
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:1624291
G Hdac7 histone deacetylase 7 JBrowse link 7 139,280,396 139,319,108 RGD:1600115
RGD:1624291
G Litaf lipopolysaccharide-induced TNF factor JBrowse link 10 4,753,546 4,763,272 RGD:1624291
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:11040458
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:13792537
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1600115
RGD:1624291
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:1600115
RGD:1624291
G Rassf2 Ras association domain family member 2 JBrowse link 3 124,574,088 124,610,267 RGD:1624291
RGD:1600115
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:1624291
G Tspan6 tetraspanin 6 JBrowse link X 104,719,930 104,729,606 RGD:1624291
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats JBrowse link 8 65,686,586 65,774,940 RGD:1624291
RGD:13792537
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
positive regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07009373.1 RGD:13792537
G AABR07019870.1 RGD:13792537
G AABR07025074.1 RGD:13792537
G AABR07029613.1 RGD:13792537
G AABR07035218.1 RGD:13792537
G AABR07054355.1 RGD:13792537
G AABR07054358.1 RGD:13792537
G AABR07060165.1 RGD:13792537
G AABR07060287.1 RGD:13792537
G AABR07067274.1 RGD:13792537
G AC094217.2 RGD:13792537
G AC108595.1 RGD:13792537
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:1624291
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G Ago1 argonaute RISC component 1 JBrowse link 5 144,444,390 144,479,430 RGD:1624291
G Ago3 argonaute RISC catalytic component 3 JBrowse link 5 144,355,792 144,436,509 RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G C1qtnf4 C1q and TNF related 4 JBrowse link 3 79,713,580 79,718,018 RGD:1624291
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:1624291
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:1624291
RGD:13792537
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:1624291
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:10059423
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Eda ectodysplasin-A JBrowse link X 69,730,123 70,222,693 RGD:1624291
RGD:13792537
G Edar ectodysplasin-A receptor JBrowse link 20 28,179,132 28,263,092 RGD:1624291
G Edaradd EDAR-associated death domain JBrowse link 17 90,802,280 90,843,476 RGD:14398762
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:13601996
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1624291
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1624291
RGD:1600115
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Glrx glutaredoxin JBrowse link 2 2,606,032 2,615,944 RGD:9686063
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:1624291
G Hmg1l1 high-mobility group (nonhistone chromosomal) protein 1-like 1 JBrowse link 19 59,984,234 59,985,494 RGD:13792537
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
RGD:13792537
G Hmgb1-ps3 high mobility group box 1, pseudogene 3 JBrowse link 7 132,982,959 132,984,167 RGD:13792537
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:1624291
RGD:1600115
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
G Lgals9 galectin 9 JBrowse link 10 64,737,022 64,760,195 RGD:1624291
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,981 28,004,767 RGD:1624291
G LOC100911637 high mobility group protein B1-like JBrowse link 3 149,741,055 149,741,953 RGD:13792537
G LOC108349189 high mobility group protein B1 pseudogene JBrowse link X 115,351,012 115,351,755 RGD:13792537
G LOC108350839 high mobility group protein B1-like JBrowse link 4 92,431,517 92,432,354 RGD:13792537
G Lrrc19 leucine rich repeat containing 19 JBrowse link 5 113,614,164 113,626,834 RGD:1624291
RGD:13792537
G Mmp8 matrix metallopeptidase 8 JBrowse link 8 5,768,808 5,777,741 RGD:1600115
RGD:1624291
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:1624291
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:1600115
RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1624291
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1600115
RGD:1624291
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:1600115
RGD:1624291
G Ptp4a3 protein tyrosine phosphatase 4A3 JBrowse link 7 114,969,699 115,002,902 RGD:1624291
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:1624291
RGD:1600115
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G RGD1563668 similar to High mobility group protein 1 (HMG-1) JBrowse link 10 40,994,237 40,994,990 RGD:13792537
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
G Rtkn2 rhotekin 2 JBrowse link 20 21,919,486 22,004,279 RGD:1624291
G Sash1 SAM and SH3 domain containing 1 JBrowse link 1 2,782,905 2,950,749 RGD:1624291
RGD:13792537
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:10042970
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1600115
RGD:1624291
G Tcim transcriptional and immune response regulator JBrowse link 16 72,401,526 72,403,180 RGD:1624291
G Terf2ip TERF2 interacting protein JBrowse link 19 44,231,317 44,238,406 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnfsf14 TNF superfamily member 14 JBrowse link 9 9,761,363 9,765,461 RGD:1624291
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Trim44 tripartite motif-containing 44 JBrowse link 3 91,968,781 92,242,138 RGD:1600115
RGD:1624291
G Trip6 thyroid hormone receptor interactor 6 JBrowse link 12 22,451,596 22,456,003 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    signaling 7531
      signal transduction 6946
        intracellular signal transduction 2594
          regulation of intracellular signal transduction 1694
            regulation of NIK/NF-kappaB signaling 130
              modulation by virus of host NIK/NF-kappaB signaling 0
              negative regulation of NIK/NF-kappaB signaling 23
              positive regulation of NIK/NF-kappaB signaling + 98
Path 2
Term Annotations click to browse term
  biological_process 19678
    biological regulation 13599
      regulation of biological process 12921
        regulation of cellular process 12405
          signal transduction 6946
            regulation of signal transduction 2971
              regulation of intracellular signal transduction 1694
                regulation of NIK/NF-kappaB signaling 130
                  modulation by virus of host NIK/NF-kappaB signaling 0
                  negative regulation of NIK/NF-kappaB signaling 23
                  positive regulation of NIK/NF-kappaB signaling + 98
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.