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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of vasculature development
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Accession:GO:1901343 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.
Synonyms:exact_synonym: down regulation of vasculature development;   downregulation of vasculature development
 narrow_synonym: inhibition of vasculature development
 related_synonym: down regulation of vascular system development;   downregulation of vascular system development;   inhibition of vascular system development;   negative regulation of vascular system development


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negative regulation of angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:12790979
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
RGD:1600115
G Adgrb2 adhesion G protein-coupled receptor B2 JBrowse link 5 148,168,530 148,231,587 RGD:1600115
G Adgrb3 adhesion G protein-coupled receptor B3 JBrowse link 9 31,280,623 32,022,535 RGD:1600115
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:7175062
G Ago1 argonaute RISC component 1 JBrowse link 5 144,444,390 144,479,430 RGD:1624291
RGD:1600115
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:5129188
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 JBrowse link 2 237,727,782 237,751,327 RGD:724676
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
RGD:1600115
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:1624291
RGD:1600115
G Angpt4 angiopoietin 4 JBrowse link 3 147,421,724 147,455,670 RGD:1624291
RGD:1600115
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:1624291
RGD:1600115
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:1624291
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1624291
RGD:1600115
G Ccr2 C-C motif chemokine receptor 2 RGD:1624291
RGD:1600115
G Cd160 CD160 molecule JBrowse link 2 198,933,681 198,965,380 RGD:1624291
RGD:1600115
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:2307224
G Cldn5 claudin 5 JBrowse link 11 86,356,292 86,357,718 RGD:1624291
G Cnmd chondromodulin JBrowse link 15 61,923,291 61,947,840 RGD:1357408
RGD:13792537
RGD:1624291
RGD:1600115
G Col4a2 collagen type IV alpha 2 chain JBrowse link 16 83,386,388 83,522,169 RGD:1624291
RGD:1600115
G Col4a3 collagen type IV alpha 3 chain JBrowse link 9 88,357,528 88,484,735 RGD:1624291
RGD:1600115
G Crhr2 corticotropin releasing hormone receptor 2 JBrowse link 4 85,286,371 85,329,374 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1600115
RGD:1624291
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:1624291
RGD:1600115
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:2311389
RGD:1624291
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
RGD:1600115
G Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator JBrowse link 18 28,507,167 28,516,567 RGD:1624291
RGD:13792537
G Efna3 ephrin A3 JBrowse link 2 188,636,304 188,645,302 RGD:1624291
G Emilin1 elastin microfibril interfacer 1 JBrowse link 6 26,821,249 26,829,013 RGD:1600115
RGD:1624291
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:1600115
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:1624291
RGD:1600115
G Foxc1 forkhead box C1 JBrowse link 17 33,947,501 33,951,484 RGD:1624291
RGD:1600115
G Foxj2 forkhead box J2 JBrowse link 4 155,653,446 155,679,815 RGD:1600115
RGD:1624291
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:1624291
RGD:1600115
G Gpr4 G protein-coupled receptor 4 JBrowse link 1 80,125,639 80,136,786 RGD:1624291
RGD:1600115
G Gtf2i general transcription factor II I JBrowse link 12 25,410,804 25,487,970 RGD:1624291
RGD:1600115
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:1600115
RGD:1624291
G Hhex hematopoietically expressed homeobox JBrowse link 1 256,101,994 256,107,581 RGD:1624291
G Hoxa5 homeo box A5 RGD:1624291
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:1600115
RGD:1624291
G Il17f interleukin 17F JBrowse link 9 26,885,702 26,897,219 RGD:1600115
RGD:1624291
G Ism1 isthmin 1 JBrowse link 3 132,736,433 132,808,544 RGD:1624291
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1624291
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:1624291
RGD:1600115
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:2326157
G LOC681544 similar to histidine-rich glycoprotein RGD:1600115
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:1624291
RGD:1600115
G Minar1 membrane integral NOTCH2 associated receptor 1 JBrowse link 8 96,970,556 97,008,687 RGD:1624291
RGD:1600115
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:10413902
G Optc opticin JBrowse link 13 50,735,509 50,748,908 RGD:1624291
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:1600115
RGD:1624291
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:1624291
RGD:1600115
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:1624291
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:1600115
RGD:1624291
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
RGD:1600115
G Prl7d1 prolactin family 7, subfamily d, member 1 JBrowse link 17 38,993,183 38,999,651 RGD:1600115
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:2292001
G Ptprm protein tyrosine phosphatase, receptor type, M JBrowse link 9 114,846,095 115,555,261 RGD:1624291
RGD:1600115
G Rgcc regulator of cell cycle JBrowse link 15 61,551,861 61,564,695 RGD:1624291
RGD:1600115
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1600115
RGD:1624291
G Sars1 seryl-tRNA synthetase 1 JBrowse link 2 211,219,743 211,235,475 RGD:1624291
RGD:1600115
G Sema3e semaphorin 3E JBrowse link 4 17,314,745 17,594,659 RGD:1624291
RGD:1600115
G Sema4a semaphorin 4A JBrowse link 2 187,799,568 187,823,014 RGD:1624291
RGD:1600115
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
G Serpina3c serine (or cysteine) proteinase inhibitor, clade A, member 3C JBrowse link 6 127,996,162 128,003,433 RGD:1580111
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:1359799
RGD:1624291
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1624291
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:1624291
RGD:1600115
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:13792537
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1600115
RGD:1624291
G Stab1 stabilin 1 JBrowse link 16 7,220,434 7,250,934 RGD:1624291
RGD:1600115
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1624291
G Sulf1 sulfatase 1 JBrowse link 5 5,999,520 6,186,901 RGD:1600115
RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
RGD:1600115
G Tcf4 transcription factor 4 JBrowse link 18 65,285,320 65,507,983 RGD:1624291
RGD:1600115
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:2307224
RGD:13792537
RGD:1624291
G Thbs2 thrombospondin 2 JBrowse link 1 56,653,929 56,683,571 RGD:1580067
RGD:13792537
RGD:1624291
RGD:1580070
G Thbs4 thrombospondin 4 JBrowse link 2 22,343,727 22,385,855 RGD:1600115
RGD:1624291
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 JBrowse link 5 137,294,544 137,321,116 RGD:1624291
RGD:1600115
G Tnmd tenomodulin JBrowse link X 104,684,676 104,700,173 RGD:1624291
RGD:13792537
G Vash1 vasohibin 1 JBrowse link 6 110,624,377 110,640,942 RGD:1624291
RGD:1600115
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxj2 forkhead box J2 JBrowse link 4 155,653,446 155,679,815 RGD:1600115
RGD:1624291
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll4 delta like canonical Notch ligand 4 JBrowse link 3 111,135,011 111,146,746 RGD:1624291
RGD:1600115
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:1600115
RGD:1624291
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
RGD:1600115
negative regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Klf5 Kruppel-like factor 5 JBrowse link 15 83,703,796 83,722,921 RGD:13210556
negative regulation of cell adhesion involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
negative regulation of cell migration involved in sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Card10 caspase recruitment domain family, member 10 JBrowse link 7 119,998,639 120,028,632 RGD:1600115
RGD:1624291
G Dll4 delta like canonical Notch ligand 4 JBrowse link 3 111,135,011 111,146,746 RGD:1624291
RGD:1600115
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
RGD:1600115
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:1624291
RGD:1600115
G Klf4 Kruppel like factor 4 JBrowse link 5 72,283,311 72,287,669 RGD:1624291
RGD:1600115
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:8553940
G Meox2 mesenchyme homeobox 2 JBrowse link 6 56,625,768 56,689,195 RGD:1600115
RGD:1624291
G Mmrn2 multimerin 2 JBrowse link 16 10,727,552 10,749,303 RGD:1624291
RGD:13792537
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:11053232
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
RGD:1600115
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:1624291
RGD:1600115
G Stard13 StAR-related lipid transfer domain containing 13 JBrowse link 12 1,023,494 1,418,919 RGD:1624291
RGD:1600115
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:1600115
RGD:1624291
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
RGD:1600115
negative regulation of ductus arteriosus closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10003042
negative regulation of glomerular mesangial cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:1600115
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:10755757
negative regulation of lymphangiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:1624291
RGD:1600115
G Foxc1 forkhead box C1 JBrowse link 17 33,947,501 33,951,484 RGD:1624291
RGD:1600115
G Vash1 vasohibin 1 JBrowse link 6 110,624,377 110,640,942 RGD:1624291
RGD:1600115
negative regulation of metanephric glomerular mesangial cell proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wt1 WT1 transcription factor JBrowse link 3 95,133,221 95,180,574 RGD:1624291
RGD:1600115
negative regulation of sprouting angiogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 JBrowse link 4 124,660,254 124,860,997 RGD:1624291
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:1600115
RGD:1624291
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:1600115
RGD:1624291
G Epn1 Epsin 1 JBrowse link 1 72,294,153 72,310,217 RGD:1600115
RGD:1624291
G Epn2 epsin 2 JBrowse link 10 47,795,496 47,857,373 RGD:1600115
RGD:1624291
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:10402115
G Klf2 Kruppel-like factor 2 JBrowse link 16 19,223,087 19,225,037 RGD:1600115
RGD:1624291
G Sema6a semaphorin 6A JBrowse link 18 41,330,519 41,451,813 RGD:1624291
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Stard13 StAR-related lipid transfer domain containing 13 JBrowse link 12 1,023,494 1,418,919 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
RGD:1600115
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
negative regulation of testicular blood vessel morphogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
negative regulation of vascular smooth muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:1600115
RGD:1624291
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1600115
RGD:1624291
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1600115
RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1624291
RGD:1600115
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1624291
RGD:1600115
negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1600115
RGD:1624291
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:13601993
negative regulation of vascular wound healing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:1624291
RGD:1600115
negative regulation of vasculogenesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1600115
RGD:1624291
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    developmental process 6597
      negative regulation of developmental process 1087
        negative regulation of vasculature development 127
          negative regulation of blood vessel endothelial cell differentiation + 1
          negative regulation of blood vessel morphogenesis + 115
          negative regulation of glomerular mesangial cell proliferation + 4
          negative regulation of lymphangiogenesis 3
          negative regulation of placenta blood vessel development 0
          negative regulation of vascular smooth muscle cell differentiation + 8
          negative regulation of vasculature development involved in avascular cornea development in camera-type eye 0
Path 2
Term Annotations click to browse term
  biological_process 19245
    developmental process 6597
      anatomical structure development 6063
        multicellular organism development 5534
          system development 5081
            circulatory system development 1196
              cardiovascular system development 762
                vasculature development 748
                  regulation of vasculature development 347
                    negative regulation of vasculature development 127
                      negative regulation of blood vessel endothelial cell differentiation + 1
                      negative regulation of blood vessel morphogenesis + 115
                      negative regulation of glomerular mesangial cell proliferation + 4
                      negative regulation of lymphangiogenesis 3
                      negative regulation of placenta blood vessel development 0
                      negative regulation of vascular smooth muscle cell differentiation + 8
                      negative regulation of vasculature development involved in avascular cornea development in camera-type eye 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.