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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of voltage-gated calcium channel activity
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Accession:GO:1901386 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity.
Synonyms:exact_synonym: down regulation of depolarization-activated voltage gated calcium channel activity;   down regulation of depolarization-activated voltage-gated calcium channel;   down regulation of voltage gated calcium channel activity;   down regulation of voltage-dependent calcium channel activity;   down regulation of voltage-gated calcium ion channel activity;   down regulation of voltage-sensitive calcium channel;   downregulation of depolarization-activated voltage gated calcium channel activity;   downregulation of depolarization-activated voltage-gated calcium channel;   downregulation of voltage gated calcium channel activity;   downregulation of voltage-dependent calcium channel activity;   downregulation of voltage-gated calcium ion channel activity;   downregulation of voltage-sensitive calcium channel;   inhibition of depolarization-activated voltage gated calcium channel activity;   inhibition of depolarization-activated voltage-gated calcium channel;   inhibition of voltage-dependent calcium channel activity;   inhibition of voltage-gated calcium ion channel activity;   inhibition of voltage-sensitive calcium channel;   negative regulation of depolarization-activated voltage gated calcium channel activity;   negative regulation of depolarization-activated voltage-gated calcium channel;   negative regulation of voltage-dependent calcium channel activity;   negative regulation of voltage-gated calcium ion channel activity;   negative regulation of voltage-sensitive calcium channel
 narrow_synonym: down regulation of dihydropyridine-sensitive calcium channel activity;   downregulation of dihydropyridine-sensitive calcium channel activity;   inhibition of dihydropyridine-sensitive calcium channel activity;   inhibition of voltage-gated calcium channel activity;   negative regulation of dihydropyridine-sensitive calcium channel activity
 broad_synonym: down regulation of depolarization-activated calcium channel;   downregulation of depolarization-activated calcium channel;   inhibition of depolarization-activated calcium channel;   negative regulation of depolarization-activated calcium channel


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negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IDA RGD PMID:17960496 RGD:7207144 NCBI chr12:47,185,449...47,209,785
Ensembl chr12:47,179,664...47,209,784
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F ISO (PMID:27226626) RGD PMID:27226626 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IDA RGD PMID:15024042 RGD:13514097 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cbarp CACN subunit beta associated regulatory protein IMP
IBA
ISO
PMID:21873635
(MGI:MGI:5607190|PMID:24751537)
RGD PMID:24751537, PMID:24751537, PMID:21873635 MGI:MGI:5607190, RGD:10047103, RGD:13792537 NCBI chr 7:12,433,422...12,441,048
Ensembl chr 7:12,433,933...12,441,048
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO (PMID:18292205) RGD PMID:18292205 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Drd2 dopamine receptor D2 ISO
IBA
IDA
(PMID:7921596)
PMID:21873635
PMID:2162345
RGD PMID:7921596, PMID:21873635, PMID:2162345 RGD:13792537, RGD:8554169 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 ISO
IEA
(PMID:7921596)
GO_REF:0000107
RGD
Ensembl
PMID:7921596 GO_REF:0000107 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gnb5 G protein subunit beta 5 IEA
ISO
ISS
GO_REF:0000107
(PMID:11007869), (PMID:12606627)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11007869, PMID:12606627 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184
JBrowse link
G Gpr35 G protein-coupled receptor 35 ISO (PMID:17940199) RGD PMID:17940199 NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:15937148 RGD:9835002 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Dysf dysferlin ISO MGI:MGI:3055150 (MGI:MGI:5545678|PMID:24302765) RGD PMID:24302765 MGI:MGI:5545678 NCBI chr 4:115,700,942...115,901,873
Ensembl chr 4:115,712,850...115,901,873
JBrowse link
G Rem1 RRAD and GEM like GTPase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:148,108,500...148,116,992
Ensembl chr 3:148,108,539...148,116,991
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    negative regulation of biological process 5696
      negative regulation of transport 552
        negative regulation of transporter activity 90
          negative regulation of ion transmembrane transporter activity 81
            negative regulation of calcium ion transmembrane transporter activity 38
              negative regulation of voltage-gated calcium channel activity 18
                negative regulation of high voltage-gated calcium channel activity 6
Path 2
Term Annotations click to browse term
  biological_process 20014
    localization 6486
      establishment of localization 4918
        transport 4774
          ion transport 1783
            cation transport 1282
              metal ion transport 951
                divalent metal ion transport 501
                  calcium ion transport 455
                    regulation of calcium ion transport 295
                      regulation of calcium ion transmembrane transport 178
                        regulation of calcium ion transmembrane transporter activity 91
                          negative regulation of calcium ion transmembrane transporter activity 38
                            negative regulation of voltage-gated calcium channel activity 18
                              negative regulation of high voltage-gated calcium channel activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.