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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signal transduction by p53 class mediator
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Accession:GO:1901797 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
Synonyms:exact_synonym: down-regulation of signal transduction by p53 class mediator;   downregulation of signal transduction by p53 class mediator
 narrow_synonym: inhibition of signal transduction by p53 class mediator


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negative regulation of signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELL3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:MGI:5438719 NCBI chr15:43,772,620...43,776,966
Ensembl chr15:43,772,605...43,777,315
JBrowse link
G MDM2 MDM2 proto-oncogene IDA
TAS
(PMID:16173922)
(PMID:23150757)
UniProtKB
ARUK-UCL
PMID:16173922, PMID:23150757 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IEA Ensembl GO_REF:0000107 NCBI chr19:47,745,546...47,757,058
Ensembl chr19:47,745,546...47,757,058
JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase IMP (PMID:17121812) UniProtKB PMID:17121812 NCBI chr17:35,005,990...35,089,226
Ensembl chr17:35,005,990...35,089,319
JBrowse link
G RNF34 ring finger protein 34 IMP (PMID:17121812) UniProtKB PMID:17121812 NCBI chr12:121,400,096...121,424,352
Ensembl chr12:121,400,041...121,430,623
JBrowse link
G SENP2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chr 3:185,586,295...185,633,551
Ensembl chr 3:185,582,496...185,633,551
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule (Indian blood group) IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD74 CD74 molecule IDA
IBA
(PMID:17045821)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:17045821, PMID:21873635 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A ISS (PMID:20736167) BHF-UCL PMID:20736167 NCBI chr21:37,365,573...37,526,358
Ensembl chr21:37,365,573...37,526,358
JBrowse link
G DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:206,635,536...206,655,158
Ensembl chr 1:206,635,536...206,684,419
JBrowse link
G KDM1A lysine demethylase 1A IMP (PMID:17805299) BHF-UCL PMID:17805299 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IMP (PMID:29295817) UniProtKB PMID:29295817 NCBI chr 2:159,712,494...159,771,027
Ensembl chr 2:159,712,457...159,771,027
JBrowse link
G MDM2 MDM2 proto-oncogene IDA (PMID:10360174), (PMID:9529249) BHF-UCL PMID:9529249, PMID:10360174 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MIF macrophage migration inhibitory factor IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G PSMD10 proteasome 26S subunit, non-ATPase 10 IDA (PMID:16023600) UniProtKB PMID:16023600 NCBI chr  X:108,084,207...108,091,542
Ensembl chr  X:108,084,207...108,091,549
JBrowse link
G PTTG1IP PTTG1 interacting protein IMP (PMID:24506068) MGI PMID:24506068 NCBI chr21:44,849,598...44,873,690
Ensembl chr21:44,849,585...44,873,903
JBrowse link
G SENP2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chr 3:185,586,295...185,633,551
Ensembl chr 3:185,582,496...185,633,551
JBrowse link
G SIRT1 sirtuin 1 IDA (PMID:11672523) BHF-UCL PMID:11672523 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SNAI1 snail family transcriptional repressor 1 IMP (PMID:15314165) BHF-UCL PMID:15314165 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 IMP (PMID:15314165) BHF-UCL PMID:15314165 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 IMP (PMID:17690110) BHF-UCL PMID:17690110 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
G YJU2 YJU2 splicing factor homolog ISS UniProtKB GO_REF:0000024 NCBI chr19:4,247,080...4,269,088
Ensembl chr19:4,247,080...4,269,088
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PCBP4 poly(rC) binding protein 4 ISO (MGI:MGI:5050389|PMID:20817677) MGI PMID:20817677 MGI:MGI:5050389 NCBI chr 3:51,957,454...51,967,466
Ensembl chr 3:51,957,454...51,974,016
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARMC10 armadillo repeat containing 10 IMP (PMID:17904127) UniProtKB PMID:17904127 NCBI chr 7:103,074,919...103,099,773
Ensembl chr 7:103,074,881...103,099,759
JBrowse link
G CEP63 centrosomal protein 63 ISO (MGI:MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:MGI:5662131 NCBI chr 3:134,485,724...134,783,169
Ensembl chr 3:134,485,721...134,575,017
JBrowse link
G MDM2 MDM2 proto-oncogene IMP (PMID:17310983) CAFA PMID:17310983 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MDM4 MDM4 regulator of p53 ISO (MGI:MGI:2182884|PMID:12101245) UniProt PMID:12101245 MGI:MGI:2182884 NCBI chr 1:204,516,377...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase IMP (PMID:23985028) ParkinsonsUK-UCL PMID:23985028 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
G PTTG1IP PTTG1 interacting protein IMP (PMID:24506068) MGI PMID:24506068 NCBI chr21:44,849,598...44,873,690
Ensembl chr21:44,849,585...44,873,903
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B IEA Ensembl GO_REF:0000107 NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961
Ensembl chr 8:102,204,502...102,238,961
JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor IEA Ensembl GO_REF:0000107 NCBI chr16:15,060,022...15,094,335
Ensembl chr16:15,060,022...15,094,317
Ensembl chr16:15,060,022...15,094,317
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 1:86,704,570...86,748,184
Ensembl chr 1:86,704,570...86,748,184
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr17:30,830,830...30,895,869
Ensembl chr17:30,831,966...30,895,869
JBrowse link
G BCL2 BCL2 apoptosis regulator TAS (PMID:1286168) BHF-UCL PMID:1286168 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L12 BCL2 like 12 IEA Ensembl GO_REF:0000107 NCBI chr19:49,664,834...49,673,916
Ensembl chr19:49,665,142...49,673,916
JBrowse link
G CD44 CD44 molecule (Indian blood group) IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD74 CD74 molecule IMP
IBA
(PMID:17045821)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:17045821, PMID:21873635 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 IEA Ensembl GO_REF:0000107 NCBI chr15:43,772,620...43,776,966
Ensembl chr15:43,772,605...43,777,315
JBrowse link
G ING2 inhibitor of growth family member 2 TAS (PMID:21124965) BHF-UCL PMID:21124965 NCBI chr 4:183,505,058...183,512,429
Ensembl chr 4:183,505,058...183,512,429
JBrowse link
G KDM1A lysine demethylase 1A IMP (PMID:17805299) BHF-UCL PMID:17805299 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IMP (PMID:29295817) UniProtKB PMID:29295817 NCBI chr 2:159,712,494...159,771,027
Ensembl chr 2:159,712,457...159,771,027
JBrowse link
G MIF macrophage migration inhibitory factor IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MUC1 mucin 1, cell surface associated IDA (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
JBrowse link
G SIRT1 sirtuin 1 ISS (PMID:11672522) BHF-UCL PMID:11672522 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 IC (PMID:15899866) BHF-UCL PMID:15899866 NCBI chr 5:69,364,743...69,369,824
Ensembl chr 5:69,364,743...69,370,013
JBrowse link
G TAF9B TATA-box binding protein associated factor 9b IC (PMID:15899866) BHF-UCL PMID:15899866 NCBI chr  X:78,129,748...78,139,650
Ensembl chr  X:78,129,748...78,139,650
JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 IMP (PMID:15735003) BHF-UCL PMID:15735003 NCBI chr12:120,443,964...120,446,384
Ensembl chr12:120,443,964...120,446,384
JBrowse link
G ZNF385A zinc finger protein 385A IMP (PMID:17719541) UniProtKB PMID:17719541 NCBI chr12:54,369,134...54,391,610
Ensembl chr12:54,369,133...54,391,298
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB2 bradykinin receptor B2 IEA Ensembl GO_REF:0000107 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    negative regulation of biological process 6183
      negative regulation of signaling 1571
        negative regulation of signal transduction 1409
          negative regulation of intracellular signal transduction 571
            negative regulation of signal transduction by p53 class mediator 38
              negative regulation of DNA damage response, signal transduction by p53 class mediator + 17
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 26
Path 2
Term Annotations click to browse term
  biological_process 18650
    biological regulation 13283
      regulation of biological process 12625
        regulation of cellular process 12020
          signal transduction 6562
            intracellular signal transduction 2978
              signal transduction by p53 class mediator 278
                regulation of signal transduction by p53 class mediator 188
                  negative regulation of signal transduction by p53 class mediator 38
                    negative regulation of DNA damage response, signal transduction by p53 class mediator + 17
                    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.