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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signal transduction by p53 class mediator
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Accession:GO:1901797 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
Synonyms:exact_synonym: down-regulation of signal transduction by p53 class mediator;   downregulation of signal transduction by p53 class mediator
 narrow_synonym: inhibition of signal transduction by p53 class mediator


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negative regulation of signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ell3 elongation factor RNA polymerase II-like 3 IDA (MGI:MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:MGI:5438719 NCBI chr 2:121,439,027...121,442,601
Ensembl chr 2:121,439,010...121,444,278
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor IMP (MGI:MGI:5897550|PMID:21804542) UniProtKB PMID:21804542 MGI:MGI:5897550 NCBI chr 7:15,937,835...15,946,108
Ensembl chr 7:15,936,183...15,946,074
JBrowse link
G Rffl ring finger and FYVE like domain containing protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:82,803,819...82,871,236
Ensembl chr11:82,802,449...82,871,210
JBrowse link
G Rnf34 ring finger protein 34 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:122,850,112...122,868,945
Ensembl chr 5:122,850,048...122,871,291
JBrowse link
G Senp2 SUMO/sentrin specific peptidase 2 IDA (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chr16:22,009,432...22,049,269
Ensembl chr16:22,009,484...22,049,269
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 antigen IMP
ISO
(MGI:MGI:3690285|PMID:17045821) BHF-UCL
MGI
PMID:17045821 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) IMP
IBA
ISO
(MGI:MGI:3690285|PMID:17045821)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
MGI
PMID:17045821, PMID:21873635 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a IDA (MGI:MGI:5318016|PMID:20736167) BHF-UCL PMID:20736167 MGI:MGI:5318016 NCBI chr16:94,569,947...94,695,519
Ensembl chr16:94,570,010...94,695,517
JBrowse link
G Dyrk3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 IMP (MGI:MGI:4838949|PMID:20167603) UniProtKB PMID:20167603 MGI:MGI:4838949 NCBI chr 1:131,128,441...131,138,234
Ensembl chr 1:131,127,455...131,138,340
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:60,209,936...60,248,385
Ensembl chr 2:60,209,887...60,250,676
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) IDA
ISO
(MGI:MGI:3690285|PMID:17045821) BHF-UCL
MGI
PMID:17045821 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr  X:140,948,425...140,956,711
Ensembl chr  X:140,948,429...140,956,728
JBrowse link
G Pttg1ip pituitary tumor-transforming 1 interacting protein ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr10:77,581,655...77,598,732
Ensembl chr10:77,581,720...77,598,732
JBrowse link
G Senp2 SUMO/sentrin specific peptidase 2 IDA (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chr16:22,009,432...22,049,269
Ensembl chr16:22,009,484...22,049,269
JBrowse link
G Sirt1 sirtuin 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Snai1 snail family zinc finger 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:167,538,195...167,542,814
Ensembl chr 2:167,538,195...167,542,814
JBrowse link
G Snai2 snail family zinc finger 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:14,705,852...14,709,395
Ensembl chr16:14,705,852...14,709,385
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 IMP (MGI:MGI:5050389|PMID:20817677) MGI PMID:20817677 MGI:MGI:5050389 NCBI chr 9:106,452,982...106,464,012
Ensembl chr 9:106,453,291...106,464,012
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc10 armadillo repeat containing 10 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:21,646,006...21,662,699
Ensembl chr 5:21,645,813...21,662,694
JBrowse link
G Cep63 centrosomal protein 63 IGI (MGI:MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:MGI:5662131 NCBI chr 9:102,586,578...102,626,564
Ensembl chr 9:102,584,588...102,626,534
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 IMP (MGI:MGI:2182884|PMID:12101245) UniProt PMID:12101245 MGI:MGI:2182884 NCBI chr 1:132,986,105...133,030,587
Ensembl chr 1:132,959,484...133,030,561
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:10,840,359...12,063,370
Ensembl chr17:10,840,384...12,063,361
JBrowse link
G Pttg1ip pituitary tumor-transforming 1 interacting protein ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr10:77,581,655...77,598,732
Ensembl chr10:77,581,720...77,598,732
JBrowse link
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) IMP (MGI:MGI:2670318|PMID:12858174) MGI PMID:12858174 MGI:MGI:2670318 NCBI chr15:37,923,952...37,961,119
Ensembl chr15:37,923,952...37,961,318
JBrowse link
G Rrn3 RRN3 RNA polymerase I transcription factor homolog (yeast) IMP (MGI:MGI:3583493|PMID:15989966) MGI PMID:15989966 MGI:MGI:3583493 NCBI chr16:13,780,699...13,814,841
Ensembl chr16:13,780,708...13,814,839
JBrowse link
G Sh3glb1 SH3-domain GRB2-like B1 (endophilin) IMP (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 3:144,683,665...144,720,408
Ensembl chr 3:144,683,678...144,720,335
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 IMP (MGI:MGI:3584078|PMID:15983387) UniProtKB PMID:15983387 MGI:MGI:3584078 NCBI chr11:80,089,379...80,135,797
Ensembl chr11:80,089,400...80,135,794
JBrowse link
G Bcl2l12 BCL2-like 12 (proline rich) IDA (MGI:MGI:4834958|PMID:20837658) MGI PMID:20837658 MGI:MGI:4834958 NCBI chr 7:44,991,222...44,997,638
Ensembl chr 7:44,991,222...44,998,712
JBrowse link
G Cd44 CD44 antigen IMP
ISO
(MGI:MGI:3690285|PMID:17045821) BHF-UCL
MGI
PMID:17045821 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) IMP
IBA
ISO
(MGI:MGI:3690285|PMID:17045821)
(MGI:MGI:6201960|PMID:21873635)
BHF-UCL
GO_Central
MGI
PMID:17045821, PMID:21873635 GO_REF:0000096, MGI:MGI:3690285, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Ell3 elongation factor RNA polymerase II-like 3 IMP (MGI:MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:MGI:5438719 NCBI chr 2:121,439,027...121,442,601
Ensembl chr 2:121,439,010...121,444,278
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:60,209,936...60,248,385
Ensembl chr 2:60,209,887...60,250,676
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:75,859,353...75,860,277
Ensembl chr10:75,859,353...75,860,240
JBrowse link
G Muc1 mucin 1, transmembrane ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 3:89,229,056...89,233,381
Ensembl chr 3:89,229,057...89,233,381
JBrowse link
G Sirt1 sirtuin 1 IMP (MGI:MGI:2152474|PMID:11672522) BHF-UCL PMID:11672522 MGI:MGI:2152474 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:115,341,231...115,343,553
Ensembl chr 5:115,341,225...115,343,569
JBrowse link
G Zfp385a zinc finger protein 385A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:103,313,895...103,340,086
Ensembl chr15:103,313,895...103,340,093
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor, beta 2 IGI (MGI:MGI:3654719|PMID:16571598) MGI PMID:16571598 MGI:MGI:3654719 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23366
    negative regulation of biological process 5680
      negative regulation of signaling 1399
        negative regulation of signal transduction 1242
          negative regulation of intracellular signal transduction 537
            negative regulation of signal transduction by p53 class mediator 33
              negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
Path 2
Term Annotations click to browse term
  biological_process 23366
    biological regulation 13064
      regulation of biological process 12440
        regulation of cellular process 11888
          signal transduction 6321
            intracellular signal transduction 2562
              signal transduction by p53 class mediator 142
                regulation of signal transduction by p53 class mediator 72
                  negative regulation of signal transduction by p53 class mediator 33
                    negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
                    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.