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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signal transduction by p53 class mediator
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Accession:GO:1901797 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
Synonyms:exact_synonym: down-regulation of signal transduction by p53 class mediator;   downregulation of signal transduction by p53 class mediator
 narrow_synonym: inhibition of signal transduction by p53 class mediator


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negative regulation of signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) RGD PMID:22768269 MGI:MGI:5438719 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:16173922) RGD PMID:16173922 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (MGI:MGI:5897550|PMID:21804542) RGD PMID:21804542 MGI:MGI:5897550 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO
ISS
(PMID:17121812)
GO_REF:0000024
RGD
UniProt
PMID:17121812 GO_REF:0000024 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Rnf34 ring finger protein 34 ISO
ISS
(PMID:17121812)
GO_REF:0000024
RGD
UniProt
PMID:17121812 GO_REF:0000024 NCBI chr12:39,164,290...39,185,209
Ensembl chr12:39,164,290...39,185,168
JBrowse link
G Senp2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) RGD PMID:21183956 MGI:MGI:5433829 NCBI chr11:82,627,973...82,664,702
Ensembl chr11:82,630,436...82,664,630
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) ISO
IEA
(PMID:17045821)
GO_REF:0000107
(MGI:MGI:3690285|PMID:17045821)
RGD
Ensembl
PMID:17045821 GO_REF:0000107, MGI:MGI:3690285 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd74 CD74 molecule ISO
IBA
ISS
(MGI:MGI:3690285|PMID:17045821)
PMID:21873635
GO_REF:0000024
(PMID:17045821)
RGD
BHF-UCL
PMID:17045821, PMID:21873635 GO_REF:0000024, MGI:MGI:3690285, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A ISO (MGI:MGI:5318016|PMID:20736167) RGD PMID:20736167 MGI:MGI:5318016 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:4838949|PMID:20167603)
Ensembl
RGD
PMID:20167603 GO_REF:0000107, MGI:MGI:4838949 NCBI chr13:47,906,230...47,916,877
Ensembl chr13:47,906,231...47,916,877
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO
ISS
(PMID:29295817)
GO_REF:0000024
RGD
UniProt
PMID:29295817 GO_REF:0000024 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:10360174), (PMID:9529249) RGD PMID:9529249, PMID:10360174 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mif macrophage migration inhibitory factor ISO (MGI:MGI:3690285|PMID:17045821)
(PMID:17045821)
RGD PMID:17045821 MGI:MGI:3690285 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 ISO
IEA
ISS
(PMID:16023600)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16023600 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:112,323,188...112,328,642
Ensembl chr  X:112,323,187...112,328,642
JBrowse link
G Pttg1ip PTTG1 interacting protein ISO (PMID:24506068) RGD PMID:24506068 NCBI chr20:11,746,369...11,764,097
Ensembl chr20:11,746,370...11,764,233
JBrowse link
G Senp2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) RGD PMID:21183956 MGI:MGI:5433829 NCBI chr11:82,627,973...82,664,702
Ensembl chr11:82,630,436...82,664,630
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:11672523)
GO_REF:0000107
RGD
Ensembl
PMID:11672523 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO (PMID:15314165) RGD PMID:15314165 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO (PMID:15314165) RGD PMID:15314165 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 ISO (MGI:MGI:5050389|PMID:20817677) RGD PMID:20817677 MGI:MGI:5050389 NCBI chr 8:115,154,848...115,165,706
Ensembl chr 8:115,155,470...115,165,706
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc10 armadillo repeat containing 10 ISO (PMID:17904127) RGD PMID:17904127 NCBI chr 4:10,004,846...10,020,017
Ensembl chr 4:10,004,848...10,020,022
JBrowse link
G Cep63 centrosomal protein 63 ISO MGI:MGI:98834 (MGI:MGI:5662131|PMID:26158450) RGD PMID:26158450 MGI:MGI:5662131 NCBI chr 8:111,063,988...111,116,014
Ensembl chr 8:111,064,049...111,116,014
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 ISO (MGI:MGI:2182884|PMID:12101245) RGD PMID:12101245 MGI:MGI:2182884 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:23985028) RGD PMID:23985028 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Pttg1ip PTTG1 interacting protein ISO (PMID:24506068) RGD PMID:24506068 NCBI chr20:11,746,369...11,764,097
Ensembl chr20:11,746,370...11,764,233
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO MGI:MGI:2672883 (MGI:MGI:2670318|PMID:12858174) RGD PMID:12858174 MGI:MGI:2670318 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO MGI:MGI:3584037 (MGI:MGI:3583493|PMID:15989966) RGD PMID:15989966 MGI:MGI:3583493 NCBI chr10:3,170,387...3,214,648
Ensembl chr10:3,170,742...3,214,655
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) RGD PMID:24523556 MGI:MGI:5553386 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:MGI:4834958 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO
IEA
(PMID:17045821)
GO_REF:0000107
(MGI:MGI:3690285|PMID:17045821)
RGD
Ensembl
PMID:17045821 GO_REF:0000107, MGI:MGI:3690285 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd74 CD74 molecule ISO
IBA
ISS
(MGI:MGI:3690285|PMID:17045821)
PMID:21873635
GO_REF:0000024
(PMID:17045821)
RGD
BHF-UCL
PMID:17045821, PMID:21873635 GO_REF:0000024, MGI:MGI:3690285, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) RGD PMID:22768269 MGI:MGI:5438719 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO
ISS
(PMID:29295817)
GO_REF:0000024
RGD
UniProt
PMID:29295817 GO_REF:0000024 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Mif macrophage migration inhibitory factor ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:2152474|PMID:11672522) RGD PMID:11672522 MGI:MGI:2152474 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Zfp385a zinc finger protein 385A ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 ISO
IEA
MGI:MGI:98834|MGI:MGI:99702 (MGI:MGI:3654719|PMID:16571598)
GO_REF:0000107
RGD
Ensembl
PMID:16571598 GO_REF:0000107, MGI:MGI:3654719 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    negative regulation of biological process 5710
      negative regulation of signaling 1403
        negative regulation of signal transduction 1243
          negative regulation of intracellular signal transduction 551
            negative regulation of signal transduction by p53 class mediator 33
              negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
Path 2
Term Annotations click to browse term
  biological_process 20017
    biological regulation 13767
      regulation of biological process 13081
        regulation of cellular process 12570
          signal transduction 7015
            intracellular signal transduction 2615
              signal transduction by p53 class mediator 140
                regulation of signal transduction by p53 class mediator 72
                  negative regulation of signal transduction by p53 class mediator 33
                    negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
                    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.