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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signal transduction by p53 class mediator
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Accession:GO:1901797 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator.
Synonyms:exact_synonym: down-regulation of signal transduction by p53 class mediator;   downregulation of signal transduction by p53 class mediator
 narrow_synonym: inhibition of signal transduction by p53 class mediator


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negative regulation of signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:MGI:5438719 NCBI chrNW_004936471:6,835,410...6,838,582 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:16173922) UniProtKB PMID:16173922 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (MGI:MGI:5897550|PMID:21804542) UniProtKB PMID:21804542 MGI:MGI:5897550 NCBI chrNW_004936664:1,334,487...1,343,867 JBrowse link
G Rffl ring finger and FYVE like domain containing E3 ubiquitin protein ligase ISO (PMID:17121812) UniProtKB PMID:17121812 NCBI chrNW_004936538:139,690...203,600 JBrowse link
G Rnf34 ring finger protein 34 ISO (PMID:17121812) UniProtKB PMID:17121812 NCBI chrNW_004936558:2,901,386...2,918,976 JBrowse link
G Senp2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chrNW_004936578:4,252,718...4,290,452 JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) ISO (MGI:MGI:3690285|PMID:17045821)
(PMID:17045821)
BHF-UCL PMID:17045821 MGI:MGI:3690285 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cd74 CD74 molecule ISO (PMID:17045821)
(MGI:MGI:3690285|PMID:17045821)
BHF-UCL PMID:17045821 MGI:MGI:3690285 NCBI chrNW_004936504:4,522,576...4,532,289 JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A ISO (MGI:MGI:5318016|PMID:20736167) BHF-UCL PMID:20736167 MGI:MGI:5318016 NCBI chrNW_004936500:5,317,109...5,423,593 JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 ISO (MGI:MGI:4838949|PMID:20167603) UniProtKB PMID:20167603 MGI:MGI:4838949 NCBI chrNW_004936557:5,947,157...5,956,874 JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) BHF-UCL PMID:17805299 NCBI chrNW_004936474:8,262,913...8,319,089 JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO (PMID:29295817) UniProtKB PMID:29295817 NCBI chrNW_004936469:18,966,239...19,016,829 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:10360174), (PMID:9529249) BHF-UCL PMID:9529249, PMID:10360174 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mif macrophage migration inhibitory factor ISO (PMID:17045821)
(MGI:MGI:3690285|PMID:17045821)
BHF-UCL PMID:17045821 MGI:MGI:3690285 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 ISO (PMID:16023600) UniProtKB PMID:16023600 NCBI chrNW_004936499:6,691,758...6,698,515 JBrowse link
G Pttg1ip PTTG1 interacting protein ISO (PMID:24506068) MGI PMID:24506068 NCBI chrNW_004936778:1,350,647...1,379,497 JBrowse link
G Senp2 SUMO specific peptidase 2 ISO (MGI:MGI:5433829|PMID:21183956) MGI PMID:21183956 MGI:MGI:5433829 NCBI chrNW_004936578:4,252,718...4,290,452 JBrowse link
G Sirt1 sirtuin 1 ISO (PMID:11672523) BHF-UCL PMID:11672523 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO (PMID:15314165) BHF-UCL PMID:15314165 NCBI chrNW_004936514:4,456,498...4,462,436 JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO (PMID:15314165) BHF-UCL PMID:15314165 NCBI chrNW_004936590:3,813,916...3,817,642 JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17690110) BHF-UCL PMID:17690110 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 ISO (MGI:MGI:5050389|PMID:20817677) MGI PMID:20817677 MGI:MGI:5050389 NCBI chrNW_004936529:3,304,171...3,308,422 JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc10 armadillo repeat containing 10 ISO (PMID:17904127) UniProtKB PMID:17904127 NCBI chrNW_004936479:20,297,385...20,315,263 JBrowse link
G Cep63 centrosomal protein 63 ISO (MGI:MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:MGI:5662131 NCBI chrNW_004936529:7,577,122...7,632,161 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:17310983) CAFA PMID:17310983 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Mdm4 MDM4 regulator of p53 ISO (MGI:MGI:2182884|PMID:12101245) UniProt PMID:12101245 MGI:MGI:2182884 NCBI chrNW_004936567:268,151...299,494 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:23985028) ParkinsonsUK-UCL PMID:23985028 NCBI chrNW_004936489:12,118,538...12,913,664 JBrowse link
G Pttg1ip PTTG1 interacting protein ISO (PMID:24506068) MGI PMID:24506068 NCBI chrNW_004936778:1,350,647...1,379,497 JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B ISO (MGI:MGI:2670318|PMID:12858174) MGI PMID:12858174 MGI:MGI:2670318 NCBI chrNW_004936470:41,354,387...41,401,308 JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO (MGI:MGI:3583493|PMID:15989966) MGI PMID:15989966 MGI:MGI:3583493 NCBI chrNW_004936501:2,893,304...2,926,795 JBrowse link
G Sh3glb1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chrNW_004936732:2,066,848...2,097,947 JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family AAA domain containing 5 ISO (MGI:MGI:3584078|PMID:15983387) UniProtKB PMID:15983387 MGI:MGI:3584078 NCBI chrNW_004936538:2,815,370...2,877,084 JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) MGI PMID:20837658 MGI:MGI:4834958 NCBI chrNW_004936664:3,482,562...3,488,663 JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO (MGI:MGI:3690285|PMID:17045821)
(PMID:17045821)
BHF-UCL PMID:17045821 MGI:MGI:3690285 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cd74 CD74 molecule ISO (MGI:MGI:3690285|PMID:17045821)
(PMID:17045821)
BHF-UCL PMID:17045821 MGI:MGI:3690285 NCBI chrNW_004936504:4,522,576...4,532,289 JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) MGI PMID:22768269 MGI:MGI:5438719 NCBI chrNW_004936471:6,835,410...6,838,582 JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) BHF-UCL PMID:17805299 NCBI chrNW_004936474:8,262,913...8,319,089 JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO (PMID:29295817) UniProtKB PMID:29295817 NCBI chrNW_004936469:18,966,239...19,016,829 JBrowse link
G Mif macrophage migration inhibitory factor ISO (PMID:17045821) BHF-UCL PMID:17045821 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:2152474|PMID:11672522) BHF-UCL PMID:11672522 MGI:MGI:2152474 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) BHF-UCL PMID:15735003 NCBI chrNW_004936668:500,815...503,158 JBrowse link
G Znf385a zinc finger protein 385A ISO (PMID:17719541) UniProtKB PMID:17719541 NCBI chrNW_004936512:11,562,635...11,585,026 JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 ISO (MGI:MGI:3654719|PMID:16571598) MGI PMID:16571598 MGI:MGI:3654719 NCBI chrNW_004936604:548,844...551,031 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    negative regulation of biological process 4659
      negative regulation of signaling 1282
        negative regulation of signal transduction 1132
          negative regulation of intracellular signal transduction 502
            negative regulation of signal transduction by p53 class mediator 33
              negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
Path 2
Term Annotations click to browse term
  biological_process 11962
    biological regulation 8755
      regulation of biological process 8316
        regulation of cellular process 7896
          signal transduction 3695
            intracellular signal transduction 1982
              signal transduction by p53 class mediator 136
                regulation of signal transduction by p53 class mediator 69
                  negative regulation of signal transduction by p53 class mediator 33
                    negative regulation of DNA damage response, signal transduction by p53 class mediator + 16
                    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.