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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of intrinsic apoptotic signaling pathway by p53 class mediator
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Accession:GO:1902253 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.
Synonyms:exact_synonym: regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
 related_synonym: regulation of signal transduction by p53 class mediator resulting in induction of apoptosis


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regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD2 ankyrin repeat domain 2 IEA Ensembl GO_REF:0000107 NCBI chr28:10,838,677...10,848,406
Ensembl chr28:10,834,411...10,848,406
JBrowse link
G TP53 tumor protein p53 IEA Ensembl GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARMC10 armadillo repeat containing 10 ISO (PMID:17904127) UniProtKB PMID:17904127 NCBI chr18:16,994,583...17,020,417
Ensembl chr18:16,995,079...17,020,840
JBrowse link
G CEP63 centrosomal protein 63 ISO (MGI:MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:MGI:5662131 NCBI chr23:31,249,517...31,303,145
Ensembl chr23:31,249,673...31,303,142
JBrowse link
G MDM2 MDM2 proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596
JBrowse link
G MDM4 MDM4 regulator of p53 ISO (MGI:MGI:2182884|PMID:12101245) UniProt PMID:12101245 MGI:MGI:2182884 NCBI chr38:1,055,978...1,122,348
Ensembl chr38:1,056,109...1,107,166
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764
JBrowse link
G PTTG1IP PTTG1 interacting protein ISO (PMID:24506068) MGI PMID:24506068 NCBI chr31:38,494,608...38,513,997 JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B IEA Ensembl GO_REF:0000107 NCBI chr13:3,774,725...3,838,576
Ensembl chr13:3,799,025...3,837,934
JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor IEA Ensembl GO_REF:0000107 NCBI chr 6:28,478,770...28,507,722
Ensembl chr 6:28,478,829...28,507,696
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 6:61,439,414...61,471,414
Ensembl chr 6:61,439,415...61,462,087
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629
JBrowse link
G BCL2L12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) MGI PMID:20837658 MGI:MGI:4834958 NCBI chr 1:106,865,346...106,873,329 JBrowse link
G CD44 CD44 molecule IEA Ensembl GO_REF:0000107 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
JBrowse link
G CD74 CD74 molecule IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 4:58,689,745...58,698,421
Ensembl chr 4:58,689,752...58,698,151
JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 IEA Ensembl GO_REF:0000107 NCBI chr30:10,514,633...10,517,963
Ensembl chr30:10,515,045...10,517,880
JBrowse link
G KDM1A lysine demethylase 1A IEA Ensembl GO_REF:0000107 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IEA Ensembl GO_REF:0000107 NCBI chr36:5,481,449...5,533,139
Ensembl chr36:5,481,456...5,531,957
JBrowse link
G MUC1 mucin 1, cell surface associated ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
JBrowse link
G SIRT1 sirtuin 1 ISO (MGI:MGI:2152474|PMID:11672522) BHF-UCL PMID:11672522 MGI:MGI:2152474 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) BHF-UCL PMID:15735003 NCBI chr26:16,349,513...16,352,805
Ensembl chr26:16,351,044...16,352,773
JBrowse link
G ZNF385A zinc finger protein 385A IEA Ensembl GO_REF:0000107 NCBI chr27:928,250...948,275
Ensembl chr27:928,349...947,186
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB2 bradykinin receptor B2 IEA Ensembl GO_REF:0000107 NCBI chr 8:64,974,588...65,005,682
Ensembl chr 8:64,974,997...65,003,407
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MSX1 msh homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:70,232,790...70,236,295
Ensembl chr 3:70,232,052...70,236,447
JBrowse link
G RPL11 ribosomal protein L11 IEA Ensembl GO_REF:0000107 NCBI chr 2:75,781,210...75,785,614
Ensembl chr 2:75,781,091...75,785,605
JBrowse link
G RPS7 ribosomal protein S7 ISO (PMID:17310983) CAFA PMID:17310983 NCBI chr17:2,139,011...2,143,160
Ensembl chr17:2,138,779...2,143,178
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 6:61,439,414...61,471,414
Ensembl chr 6:61,439,415...61,462,087
JBrowse link
G UBB ubiquitin B ISO (PMID:17571083) MGI PMID:17571083 NCBI chr 5:39,533,365...39,535,120
Ensembl chr 5:39,511,426...39,535,815
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC608703 60S ribosomal protein L26 IEA Ensembl GO_REF:0000107 NCBI chr24:15,910,414...15,910,935 JBrowse link
G RPL26 ribosomal protein L26 IEA Ensembl GO_REF:0000107 NCBI chr 5:33,152,114...33,158,237
Ensembl chr 5:33,152,113...33,158,302
JBrowse link
G STEAP3 STEAP3 metalloreductase ISO (MGI:MGI:4367682|PMID:18617898) MGI PMID:18617898 MGI:MGI:4367682 NCBI chr19:30,745,910...30,795,310
Ensembl chr19:30,747,921...30,795,338
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3584078|PMID:15983387) MGI PMID:15983387 MGI:MGI:3584078 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839
JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNRNPK heterogeneous nuclear ribonucleoprotein K IEA Ensembl GO_REF:0000107 NCBI chr 1:75,499,334...75,511,525
Ensembl chr 1:75,499,393...75,511,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    cellular process 15440
      signal transduction 5450
        intracellular signal transduction 2482
          signal transduction by p53 class mediator 140
            intrinsic apoptotic signaling pathway by p53 class mediator 78
              regulation of intrinsic apoptotic signaling pathway by p53 class mediator 32
                negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 21
                positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 9
                regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
                regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
Path 2
Term Annotations click to browse term
  biological_process 16162
    biological regulation 11530
      regulation of biological process 10939
        regulation of cellular process 10481
          regulation of cell death 1719
            regulation of programmed cell death 1555
              regulation of apoptotic process 1528
                regulation of apoptotic signaling pathway 422
                  regulation of intrinsic apoptotic signaling pathway 176
                    regulation of intrinsic apoptotic signaling pathway by p53 class mediator 32
                      negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 21
                      positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 9
                      regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
                      regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.