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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of intrinsic apoptotic signaling pathway by p53 class mediator
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Accession:GO:1902253 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.
Synonyms:exact_synonym: regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
 related_synonym: regulation of signal transduction by p53 class mediator resulting in induction of apoptosis


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regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD2 ankyrin repeat domain 2 IEA Ensembl GO_REF:0000107 NCBI chr10:97,572,441...97,583,884
Ensembl chr10:97,572,499...97,583,884
JBrowse link
G TP53 tumor protein p53 IEA Ensembl GO_REF:0000107 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARMC10 armadillo repeat containing 10 IMP (PMID:17904127) UniProtKB PMID:17904127 NCBI chr 7:103,074,919...103,099,773
Ensembl chr 7:103,074,881...103,099,759
JBrowse link
G CEP63 centrosomal protein 63 ISO (MGI:MGI:5662131|PMID:26158450) MGI PMID:26158450 MGI:MGI:5662131 NCBI chr 3:134,485,724...134,783,169
Ensembl chr 3:134,485,721...134,575,017
JBrowse link
G MDM2 MDM2 proto-oncogene IMP (PMID:17310983) CAFA PMID:17310983 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G MDM4 MDM4 regulator of p53 ISO (MGI:MGI:2182884|PMID:12101245) UniProt PMID:12101245 MGI:MGI:2182884 NCBI chr 1:204,516,377...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase IMP (PMID:23985028) ParkinsonsUK-UCL PMID:23985028 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
G PTTG1IP PTTG1 interacting protein IMP (PMID:24506068) MGI PMID:24506068 NCBI chr21:44,849,598...44,873,690
Ensembl chr21:44,849,585...44,873,903
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B IEA Ensembl GO_REF:0000107 NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961
Ensembl chr 8:102,204,502...102,238,961
JBrowse link
G RRN3 RRN3 homolog, RNA polymerase I transcription factor IEA Ensembl GO_REF:0000107 NCBI chr16:15,060,022...15,094,335
Ensembl chr16:15,060,022...15,094,317
Ensembl chr16:15,060,022...15,094,317
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 1:86,704,570...86,748,184
Ensembl chr 1:86,704,570...86,748,184
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 IEA Ensembl GO_REF:0000107 NCBI chr17:30,830,830...30,895,869
Ensembl chr17:30,831,966...30,895,869
JBrowse link
G BCL2 BCL2 apoptosis regulator TAS (PMID:1286168) BHF-UCL PMID:1286168 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L12 BCL2 like 12 IEA Ensembl GO_REF:0000107 NCBI chr19:49,664,834...49,673,916
Ensembl chr19:49,665,142...49,673,916
JBrowse link
G CD44 CD44 molecule (Indian blood group) IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD74 CD74 molecule IMP
IBA
(PMID:17045821)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:17045821, PMID:21873635 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 IEA Ensembl GO_REF:0000107 NCBI chr15:43,772,620...43,776,966
Ensembl chr15:43,772,605...43,777,315
JBrowse link
G ING2 inhibitor of growth family member 2 TAS (PMID:21124965) BHF-UCL PMID:21124965 NCBI chr 4:183,505,058...183,512,429
Ensembl chr 4:183,505,058...183,512,429
JBrowse link
G KDM1A lysine demethylase 1A IMP (PMID:17805299) BHF-UCL PMID:17805299 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IMP (PMID:29295817) UniProtKB PMID:29295817 NCBI chr 2:159,712,494...159,771,027
Ensembl chr 2:159,712,457...159,771,027
JBrowse link
G MIF macrophage migration inhibitory factor IDA (PMID:17045821) BHF-UCL PMID:17045821 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
JBrowse link
G MUC1 mucin 1, cell surface associated IDA (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
JBrowse link
G SIRT1 sirtuin 1 ISS (PMID:11672522) BHF-UCL PMID:11672522 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 IC (PMID:15899866) BHF-UCL PMID:15899866 NCBI chr 5:69,364,743...69,369,824
Ensembl chr 5:69,364,743...69,370,013
JBrowse link
G TAF9B TATA-box binding protein associated factor 9b IC (PMID:15899866) BHF-UCL PMID:15899866 NCBI chr  X:78,129,748...78,139,650
Ensembl chr  X:78,129,748...78,139,650
JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 IMP (PMID:15735003) BHF-UCL PMID:15735003 NCBI chr12:120,443,964...120,446,384
Ensembl chr12:120,443,964...120,446,384
JBrowse link
G ZNF385A zinc finger protein 385A IMP (PMID:17719541) UniProtKB PMID:17719541 NCBI chr12:54,369,134...54,391,610
Ensembl chr12:54,369,133...54,391,298
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB2 bradykinin receptor B2 IEA Ensembl GO_REF:0000107 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MSX1 msh homeobox 1 IDA (PMID:15705871) BHF-UCL PMID:15705871 NCBI chr 4:4,859,665...4,863,936
Ensembl chr 4:4,859,665...4,863,936
JBrowse link
G RPL11 ribosomal protein L11 IEA Ensembl GO_REF:0000107 NCBI chr 1:23,691,779...23,696,835
Ensembl chr 1:23,691,742...23,696,835
JBrowse link
G RPS7 ribosomal protein S7 IMP (PMID:17310983) CAFA PMID:17310983 NCBI chr 2:3,575,260...3,580,920
Ensembl chr 2:3,575,260...3,580,920
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO (MGI:MGI:5553386|PMID:24523556) UniProtKB PMID:24523556 MGI:MGI:5553386 NCBI chr 1:86,704,570...86,748,184
Ensembl chr 1:86,704,570...86,748,184
JBrowse link
G UBB ubiquitin B IDA (PMID:17571083) MGI PMID:17571083 NCBI chr17:16,380,779...16,382,745
Ensembl chr17:16,380,798...16,382,745
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPL26 ribosomal protein L26 IMP (PMID:16213212) CAFA PMID:16213212 NCBI chr17:8,377,516...8,383,193
Ensembl chr17:8,377,516...8,383,213
JBrowse link
G STEAP3 STEAP3 metalloreductase ISO (MGI:MGI:4367682|PMID:18617898) MGI PMID:18617898 MGI:MGI:4367682 NCBI chr 2:119,222,476...119,265,652
Ensembl chr 2:119,223,831...119,265,652
JBrowse link
G TP73 tumor protein p73 ISO (MGI:MGI:3584078|PMID:15983387) MGI PMID:15983387 MGI:MGI:3584078 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNRNPK heterogeneous nuclear ribonucleoprotein K IEA Ensembl GO_REF:0000107 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    cellular process 17668
      signal transduction 6562
        intracellular signal transduction 2978
          signal transduction by p53 class mediator 278
            intrinsic apoptotic signaling pathway by p53 class mediator 84
              regulation of intrinsic apoptotic signaling pathway by p53 class mediator 36
                negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 26
                positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 8
                regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 20
                regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
Path 2
Term Annotations click to browse term
  biological_process 18650
    biological regulation 13283
      regulation of biological process 12625
        regulation of cellular process 12020
          regulation of cell death 1975
            regulation of programmed cell death 1801
              regulation of apoptotic process 1774
                regulation of apoptotic signaling pathway 457
                  regulation of intrinsic apoptotic signaling pathway 185
                    regulation of intrinsic apoptotic signaling pathway by p53 class mediator 36
                      negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 26
                      positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 8
                      regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 20
                      regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.