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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction involved in mitotic DNA integrity checkpoint
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Accession:GO:1902403 term browser browse the term
Definition:Any intracellular signal transduction that is involved in mitotic DNA integrity checkpoint.
Synonyms:exact_synonym: intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signal transduction involved in topo II checkpoint;   intracellular signal transduction involved in topoisomerase II checkpoint;   intracellular signaling cascade involved in mitotic DNA integrity checkpoint;   intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling cascade involved in topo II checkpoint;   intracellular signaling cascade involved in topoisomerase II checkpoint;   intracellular signaling chain involved in mitotic DNA integrity checkpoint;   intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling chain involved in topo II checkpoint;   intracellular signaling chain involved in topoisomerase II checkpoint
 narrow_synonym: intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint;   intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signal transduction pathway involved in topo II checkpoint;   intracellular signal transduction pathway involved in topoisomerase II checkpoint;   signal transmission via intracellular cascade involved in mitotic DNA integrity checkpoint;   signal transmission via intracellular cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint;   signal transmission via intracellular cascade involved in topo II checkpoint;   signal transmission via intracellular cascade involved in topoisomerase II checkpoint
 related_synonym: intracellular signaling pathway involved in mitotic DNA integrity checkpoint;   intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint;   intracellular signaling pathway involved in topo II checkpoint;   intracellular signaling pathway involved in topoisomerase II checkpoint;   signal transduction via intracellular signaling cascade involved in mitotic DNA integrity checkpoint;   signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint;   signal transduction via intracellular signaling cascade involved in topo II checkpoint;   signal transduction via intracellular signaling cascade involved in topoisomerase II checkpoint


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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 7 36,395,665 36,408,588 RGD:1624291
RGD:13792537
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
G Sox4 SRY-box transcription factor 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
signal transduction involved in mitotic G1 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cell cycle checkpoint 188
        mitotic cell cycle checkpoint 134
          mitotic DNA integrity checkpoint 71
            signal transduction involved in mitotic DNA integrity checkpoint 16
              signal transduction involved in mitotic DNA damage checkpoint + 16
              signal transduction involved in mitotic DNA replication checkpoint 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        negative regulation of biological process 5617
          negative regulation of cellular process 5079
            negative regulation of cell cycle 461
              cell cycle checkpoint 188
                mitotic cell cycle checkpoint 134
                  mitotic DNA integrity checkpoint 71
                    signal transduction involved in mitotic DNA integrity checkpoint 16
                      signal transduction involved in mitotic DNA damage checkpoint + 16
                      signal transduction involved in mitotic DNA replication checkpoint 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.