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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death


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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F ISO
ISS
(PMID:26387735)
GO_REF:0000024
RGD
UniProt
PMID:26387735 GO_REF:0000024 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin IMP PMID:26387735 UniProt PMID:26387735 RGD:13441202 NCBI chr19:55,880,549...55,914,729
Ensembl chr19:55,880,561...55,915,502
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist ISO MGI:MGI:1929260 (MGI:MGI:5566519|PMID:20436477) RGD PMID:20436477 MGI:MGI:5566519 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IEA
ISS
ISO
GO_REF:0000107
PMID:18188704
(PMID:18188704)
Ensembl
RGD
PMID:18188704, PMID:18188704 GO_REF:0000107, RGD:8553738 NCBI chr 1:263,913,901...263,920,989
Ensembl chr 1:263,913,854...263,920,962
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO
IBA
(PMID:18371312)
PMID:21873635
RGD PMID:18371312, PMID:21873635 RGD:13792537 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 ISO (MGI:MGI:2158099|PMID:11700312) RGD PMID:11700312 MGI:MGI:2158099 NCBI chr 3:162,285,275...162,470,642
Ensembl chr 3:162,346,490...162,470,065
JBrowse link
G LOC102548901 protein Bop-like ISO (PMID:23055042) RGD PMID:23055042 NCBI chr12:6,230,524...6,231,398 JBrowse link
G Rhot1 ras homolog family member T1 ISO (PMID:12482879) RGD PMID:12482879 NCBI chr10:67,559,277...67,640,622
Ensembl chr10:67,532,030...67,640,555
JBrowse link
G Rhot2 ras homolog family member T2 ISO
ISS
(PMID:12482879)
GO_REF:0000024
RGD
UniProt
PMID:12482879 GO_REF:0000024 NCBI chr10:15,205,943...15,211,739
Ensembl chr10:15,205,534...15,211,325
JBrowse link
G Vdac2 voltage-dependent anion channel 2 ISO
ISS
(PMID:31015432)
GO_REF:0000024
RGD
UniProt
PMID:31015432 GO_REF:0000024 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18371312)
Ensembl
UniProt
RGD
PMID:18371312 GO_REF:0000024, GO_REF:0000107 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO (MGI:MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:MGI:5796062 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit ISO MGI:MGI:104995 (MGI:MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:MGI:3047441 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ier3 immediate early response 3 ISO (MGI:MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:MGI:4437986 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:3,321,488...3,359,219
Ensembl chr10:3,321,476...3,357,470
JBrowse link
G Slc25a5 solute carrier family 25 member 5 ISO
ISS
(PMID:19154410)
GO_REF:0000024
RGD
UniProt
PMID:19154410 GO_REF:0000024 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc35f6 solute carrier family 35, member F6 ISO
ISS
(PMID:19154410)
GO_REF:0000024
RGD
UniProt
PMID:19154410 GO_REF:0000024 NCBI chr 6:27,095,144...27,106,982
Ensembl chr 6:27,095,141...27,107,030
JBrowse link
G Tmem14a transmembrane protein 14A ISO
IBA
(PMID:21723035)
PMID:21873635
RGD PMID:21723035, PMID:21873635 RGD:13792537 NCBI chr 9:27,333,956...27,345,612
NCBI chr 9:27,334,103...27,351,302
Ensembl chr 9:27,343,853...27,345,070
Ensembl chr 9:27,343,853...27,345,070
JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO
ISS
(PMID:22304920)
GO_REF:0000024
RGD
UniProt
PMID:22304920 GO_REF:0000024 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO MGI:MGI:1197519 (MGI:MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:MGI:3581932 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l11 BCL2 like 11 ISO MGI:MGI:99702 (MGI:MGI:3581932|PMID:15967824) RGD PMID:15967824 MGI:MGI:3581932 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Stpg1 sperm-tail PG-rich repeat containing 1 ISO
IBA
(PMID:23028632)
PMID:21873635
RGD PMID:23028632, PMID:21873635 RGD:13792537 NCBI chr 5:153,834,263...153,888,510
Ensembl chr 5:153,835,821...153,888,506
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 ISO (MGI:MGI:4437986|PMID:19096392) RGD PMID:19096392 MGI:MGI:4437986 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO
ISS
(MGI:MGI:5796067|PMID:26949185)
GO_REF:0000024
RGD
UniProt
PMID:26949185 GO_REF:0000024, MGI:MGI:5796067 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 ISO (PMID:26666268), (PMID:30092269) RGD PMID:26666268, PMID:30092269 NCBI chr20:13,665,046...13,666,845
Ensembl chr20:13,665,031...13,667,333
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO
ISS
(MGI:MGI:5514334|PMID:16543145)
GO_REF:0000024
RGD
UniProt
PMID:16543145 GO_REF:0000024, MGI:MGI:5514334 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO
ISS
(MGI:MGI:5514334|PMID:16543145)
GO_REF:0000024
RGD
UniProt
PMID:16543145 GO_REF:0000024, MGI:MGI:5514334 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hip1r huntingtin interacting protein 1 related ISO UniProtKB:Q9HD36 (PMID:19255499) RGD PMID:19255499 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:137,209,999...137,214,379
Ensembl chr 6:137,210,052...137,214,388
JBrowse link
G Zfp13 zinc finger protein 13 ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:12,908,643...12,916,784
Ensembl chr10:12,908,643...12,916,784
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 ISO
IBA
MGI:MGI:2681654 (MGI:MGI:3804133|PMID:16705087)
PMID:21873635
(PMID:17024184)
RGD PMID:16705087, PMID:17024184, PMID:21873635 MGI:MGI:3804133, RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO MGI:MGI:2678372 (MGI:MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:MGI:2675761 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 ISO
IEA
(MGI:MGI:3607027|PMID:16227588)
GO_REF:0000107
RGD
Ensembl
PMID:16227588 GO_REF:0000107, MGI:MGI:3607027 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator ISO
IEA
MGI:MGI:1857429 (MGI:MGI:2675761|PMID:12952892)
GO_REF:0000107
RGD
Ensembl
PMID:12952892 GO_REF:0000107, MGI:MGI:2675761 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Moap1 modulator of apoptosis 1 ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (PMID:18591963) RGD PMID:18591963 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Tmem102 transmembrane protein 102 ISO (PMID:17828305) RGD PMID:17828305 NCBI chr10:56,410,898...56,413,154
Ensembl chr10:56,410,918...56,412,544
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell death 2137
        programmed cell death 1948
          mitochondrial outer membrane permeabilization involved in programmed cell death 38
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 36
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            mitochondrion organization 547
              mitochondrial membrane organization 111
                regulation of mitochondrial membrane permeability 58
                  positive regulation of mitochondrial membrane permeability 41
                    mitochondrial outer membrane permeabilization involved in programmed cell death 38
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.