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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:1600115
RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1624291
G Fkbp1a FKBP prolyl isomerase 1A JBrowse link 3 147,042,944 147,062,725 RGD:1624291
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1624291
RGD:1600115
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flot2 flotillin 2 JBrowse link 10 65,304,901 65,329,332 RGD:1624291
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1624291
negative regulation of amyloid-beta formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:1600115
RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1600115
RGD:1624291
G Bin1 bridging integrator 1 JBrowse link 18 25,163,575 25,222,139 RGD:1600115
RGD:1624291
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1624291
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1600115
RGD:1624291
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 JBrowse link 10 104,137,655 104,156,576 RGD:1624291
G Hap1 huntingtin-associated protein 1 JBrowse link 10 88,257,975 88,266,210 RGD:10047200
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1600115
RGD:1624291
G Olfm1 olfactomedin 1 JBrowse link 3 6,761,031 6,798,739 RGD:1624291
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:1624291
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Spon1 spondin 1 JBrowse link 1 178,568,777 178,935,715 RGD:1624291
RGD:1600115
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bin1 bridging integrator 1 JBrowse link 18 25,163,575 25,222,139 RGD:1600115
RGD:1624291
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1624291
RGD:1600115
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1624291
G Spon1 spondin 1 JBrowse link 1 178,568,777 178,935,715 RGD:1624291
RGD:1600115
positive regulation of amyloid-beta formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:14697726
RGD:1600115
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 20 9,743,269 9,842,735 RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:13825190
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1600115
RGD:1624291
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1624291
RGD:1600115
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:10395238
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1624291
G Gsap gamma-secretase activating protein JBrowse link 4 10,423,090 10,517,887 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:1624291
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 JBrowse link 20 25,990,304 26,163,656 RGD:1624291
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1624291
RGD:1600115
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1600115
RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
G Efna3 ephrin A3 JBrowse link 2 188,636,304 188,645,302 RGD:1624291
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1624291
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:1624291
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1624291
RGD:1600115
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1600115
RGD:1624291
regulation of amyloid-beta formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Olfm1 olfactomedin 1 JBrowse link 3 6,761,031 6,798,739 RGD:1624291
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1624291
G Tmed10 transmembrane p24 trafficking protein 10 JBrowse link 6 109,169,739 109,205,004 RGD:1624291
RGD:1600115
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Picalm phosphatidylinositol binding clathrin assembly protein JBrowse link 1 154,377,229 154,458,966 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    metabolic process 11554
      regulation of metabolic process 6536
        regulation of macromolecule metabolic process 6017
          regulation of protein metabolic process 2928
            regulation of amyloid precursor protein catabolic process 36
              negative regulation of amyloid precursor protein catabolic process + 16
              positive regulation of amyloid precursor protein catabolic process + 22
              regulation of amyloid-beta formation + 30
              regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 10
              regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 19332
    metabolic process 11554
      organic substance metabolic process 10949
        macromolecule metabolic process 9418
          protein metabolic process 5973
            amyloid precursor protein metabolic process 61
              amyloid precursor protein catabolic process 46
                regulation of amyloid precursor protein catabolic process 36
                  negative regulation of amyloid precursor protein catabolic process + 16
                  positive regulation of amyloid precursor protein catabolic process + 22
                  regulation of amyloid-beta formation + 30
                  regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 10
                  regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.