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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:1624291
RGD:1600115
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
RGD:1600115
G Svip small VCP interacting protein JBrowse link 1 107,368,117 107,373,807 RGD:10047192
RGD:1624291
G Usp14 ubiquitin specific peptidase 14 JBrowse link 18 1,178,785 1,216,573 RGD:1624291
RGD:1600115
negative regulation of ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp11 aquaporin 11 JBrowse link 1 162,703,394 162,713,560 RGD:1600115
G Ubxn1 UBX domain protein 1 JBrowse link 1 225,067,953 225,071,944 RGD:1624291
RGD:1600115
G Usp25 ubiquitin specific peptidase 25 JBrowse link 11 15,436,080 15,558,646 RGD:1624291
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:1624291
RGD:1600115
G F8a1 coagulation factor VIII-associated 1 JBrowse link 1 147,021,436 147,022,950 RGD:1624291
RGD:1600115
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:1624291
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:13514081
RGD:1624291
G Lamp3 lysosomal-associated membrane protein 3 JBrowse link 11 84,930,965 85,000,694 RGD:1624291
G Marchf7 membrane associated ring-CH-type finger 7 JBrowse link 3 46,284,961 46,325,230 RGD:1624291
RGD:1600115
G Ophn1 oligophrenin 1 JBrowse link X 68,185,865 68,579,518 RGD:1624291
RGD:13792537
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:1624291
RGD:1600115
G Psme3ip1 proteasome activator subunit 3 interacting protein 1 JBrowse link 19 10,827,057 10,856,747 RGD:1600115
RGD:1624291
G Psmf1 proteasome inhibitor subunit 1 JBrowse link 3 147,238,111 147,263,275 RGD:1600115
RGD:1624291
G Sco1 SCO cytochrome c oxidase assembly protein 1 JBrowse link 10 53,595,854 53,608,437 RGD:1624291
RGD:1600115
G Usp19 ubiquitin specific peptidase 19 JBrowse link 8 117,280,690 117,291,729 RGD:1624291
RGD:1600115
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag5 BCL2-associated athanogene 5 JBrowse link 6 136,180,640 136,185,651 RGD:1624291
G Bag6 BCL2-associated athanogene 6 JBrowse link 20 5,124,512 5,138,084 RGD:1624291
RGD:1600115
G Camlg calcium modulating ligand JBrowse link 17 9,523,792 9,534,683 RGD:1600115
RGD:1624291
G Ccar2 cell cycle and apoptosis regulator 2 JBrowse link 15 51,818,887 51,834,443 RGD:1624291
RGD:1600115
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
RGD:1600115
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1600115
RGD:1624291
G Fhit fragile histidine triad diadenosine triphosphatase JBrowse link 15 15,697,292 16,862,873 RGD:1624291
RGD:1600115
G Gipc1 GIPC PDZ domain containing family, member 1 JBrowse link 19 24,786,604 24,798,231 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1600115
RGD:1624291
G Klhl40 kelch-like family member 40 JBrowse link 8 130,416,265 130,421,871 RGD:1624291
RGD:13792537
G Map1a microtubule-associated protein 1A JBrowse link 3 113,251,918 113,272,193 RGD:1624291
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
G N4bp1 Nedd4 binding protein 1 JBrowse link 19 21,218,123 21,268,539 RGD:1624291
RGD:1600115
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
RGD:1600115
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:1600115
RGD:1624291
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
G Pbk PDZ binding kinase JBrowse link 15 42,489,253 42,500,377 RGD:1624291
RGD:1600115
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:1624291
RGD:1600115
G Rybp RING1 and YY1 binding protein JBrowse link 4 132,689,623 132,740,823 RGD:1624291
RGD:1600115
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
RGD:1600115
G Senp1 SUMO specific peptidase 1 JBrowse link 7 139,626,444 139,684,587 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 JBrowse link 8 118,206,678 118,326,264 RGD:1624291
RGD:1600115
G Taf9 TATA-box binding protein associated factor 9 JBrowse link 2 30,664,407 30,668,414 RGD:1624291
G Tlk2 tousled-like kinase 2 JBrowse link 10 93,410,181 93,507,277 RGD:1624291
RGD:1600115
G Ubxn1 UBX domain protein 1 JBrowse link 1 225,067,953 225,071,944 RGD:1624291
RGD:1600115
G Uchl5 ubiquitin C-terminal hydrolase L5 JBrowse link 13 60,568,102 60,603,812 RGD:1624291
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:1600115
RGD:1624291
G Wac WW domain containing adaptor with coiled-coil JBrowse link 17 60,887,606 60,946,630 RGD:1624291
RGD:1600115
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:1624291
RGD:1600115
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:1624291
G Erlec1 endoplasmic reticulum lectin 1 JBrowse link 14 115,314,890 115,352,871 RGD:1624291
RGD:1600115
G Os9 OS9, endoplasmic reticulum lectin JBrowse link 7 70,378,625 70,407,135 RGD:1624291
RGD:1600115
G Svip small VCP interacting protein JBrowse link 1 107,368,117 107,373,807 RGD:1624291
RGD:1600115
G Ubac2 UBA domain containing 2 JBrowse link 15 108,286,407 108,433,531 RGD:1624291
RGD:1600115
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 JBrowse link 20 11,700,089 11,721,823 RGD:1624291
RGD:1600115
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 JBrowse link 5 48,274,387 48,292,699 RGD:1624291
RGD:1600115
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1600115
RGD:1624291
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Styx serine/threonine/tyrosine interacting protein JBrowse link 15 19,690,079 19,720,683 RGD:1624291
RGD:13792537
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anks1a ankyrin repeat and sterile alpha motif domain containing 1A JBrowse link 20 7,484,550 7,636,498 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:1624291
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:1600115
RGD:1624291
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:1624291
RGD:1600115
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1600115
RGD:1624291
G Pdcl3 phosducin-like 3 JBrowse link 9 45,672,257 45,680,728 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
RGD:1600115
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Qrich2 glutamine rich 2 JBrowse link 10 105,397,470 105,422,811 RGD:1624291
RGD:1600115
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:1624291
G Rpl23 ribosomal protein L23 JBrowse link 10 85,721,398 85,725,359 RGD:1624291
RGD:1600115
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:1624291
G Rps7 ribosomal protein S7 JBrowse link 6 47,899,525 47,904,389 RGD:1624291
G Sgta small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 7 11,521,949 11,538,691 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
RGD:1600115
G Taf1 TATA-box binding protein associated factor 1 JBrowse link X 71,412,291 71,486,456 RGD:1624291
G Trim39 tripartite motif-containing 39 JBrowse link 20 2,500,691 2,514,546 RGD:1624291
RGD:1600115
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      primary metabolic process 10300
        protein metabolic process 5943
          proteolysis 1817
            negative regulation of proteolysis 403
              negative regulation of proteolysis involved in cellular protein catabolic process 74
                negative regulation of proteasomal protein catabolic process + 54
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 51
Path 2
Term Annotations click to browse term
  biological_process 19245
    biological regulation 13198
      regulation of biological process 12516
        regulation of metabolic process 6410
          regulation of macromolecule metabolic process 5912
            regulation of protein metabolic process 2899
              regulation of protein catabolic process 397
                negative regulation of protein catabolic process 134
                  negative regulation of cellular protein catabolic process 88
                    negative regulation of proteolysis involved in cellular protein catabolic process 74
                      negative regulation of proteasomal protein catabolic process + 54
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.