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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217
Ensembl chrNW_004955545:1,610,929...1,617,460
JBrowse link
G Epha4 EPH receptor A4 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chrNW_004955495:5,025,038...5,051,810
Ensembl chrNW_004955495:5,031,229...5,052,389
JBrowse link
G Svip small VCP interacting protein ISO (PMID:17872946) UniProtKB PMID:17872946 NCBI chrNW_004955476:3,231,789...3,236,602 JBrowse link
G Usp14 ubiquitin specific peptidase 14 ISO (PMID:19135427) ParkinsonsUK-UCL PMID:19135427 NCBI chrNW_004955402:9,710,080...9,737,601
Ensembl chrNW_004955402:9,710,080...9,743,077
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 ISO (MGI:3813160|PMID:18606867) UniProt PMID:18606867 MGI:3813160 NCBI chrNW_004955414:14,245,682...14,260,717
Ensembl chrNW_004955414:14,245,682...14,260,717
JBrowse link
G Ubxn1 UBX domain protein 1 ISO (PMID:21135095) ParkinsonsUK-UCL PMID:21135095 NCBI chrNW_004955599:526,792...529,825
Ensembl chrNW_004955599:526,966...529,735
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO (PMID:22590560) ParkinsonsUK-UCL PMID:22590560 NCBI chrNW_004955407:17,429,299...17,572,138
Ensembl chrNW_004955407:17,429,299...17,575,262
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO (PMID:8175643) CAFA PMID:8175643 NCBI chrNW_004955419:14,093,010...14,104,376
Ensembl chrNW_004955419:14,093,010...14,104,545
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 ISO (PMID:21669198) BHF-UCL PMID:21669198 NCBI chrNW_004955484:1,991,020...2,004,925
Ensembl chrNW_004955484:1,991,020...2,004,925
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO PMID:17517623
(MGI:6148636|PMID:17517623)
ARUK-UCL PMID:17517623 MGI:6148636, RGD:13514081 NCBI chrNW_004955437:9,872,649...9,878,459
Ensembl chrNW_004955437:9,873,908...9,878,459
JBrowse link
G Lamp3 lysosomal associated membrane protein 3 ISO (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chrNW_004955420:24,155,793...24,185,366 JBrowse link
G LOC102030058 protein SCO1 homolog, mitochondrial ISO (MGI:5643882|PMID:25683716) MGI PMID:25683716 MGI:5643882 NCBI chrNW_004955467:6,519,873...6,535,321
Ensembl chrNW_004955467:6,519,873...6,537,753
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO (PMID:29295817) UniProtKB PMID:29295817 NCBI chrNW_004955449:13,834,561...13,875,864
Ensembl chrNW_004955449:13,835,811...13,859,699
JBrowse link
G Ophn1 oligophrenin 1 ISO (MGI:5303043|PMID:21874017) UniProt PMID:21874017 MGI:5303043 NCBI chrNW_004955475:7,576,629...8,019,132
Ensembl chrNW_004955475:7,581,675...8,018,139
JBrowse link
G Prkcg protein kinase C gamma ISO (MGI:5467682|PMID:23185022) UniProt PMID:23185022 MGI:5467682 NCBI chrNW_004955604:262,182...279,259
Ensembl chrNW_004955604:262,071...279,259
JBrowse link
G Psme3ip1 proteasome activator subunit 3 interacting protein 1 ISO (PMID:29934401) UniProt PMID:29934401 NCBI chrNW_004955433:14,813,688...14,843,446
Ensembl chrNW_004955433:14,813,688...14,843,223
JBrowse link
G Psmf1 proteasome inhibitor subunit 1 ISO (PMID:10764772) UniProtKB PMID:10764772 NCBI chrNW_004955596:381,080...414,307
Ensembl chrNW_004955596:381,068...416,055
JBrowse link
G Usp19 ubiquitin specific peptidase 19 ISO (MGI:5614537|PMID:25088257) ParkinsonsUK-UCL PMID:25088257 MGI:5614537 NCBI chrNW_004955532:1,104,212...1,115,267
Ensembl chrNW_004955532:1,104,591...1,113,567
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag5 BAG cochaperone 5 ISO (PMID:24475098) ParkinsonsUK-UCL PMID:24475098 NCBI chrNW_004955538:2,412,297...2,416,094
Ensembl chrNW_004955538:2,412,297...2,415,132
JBrowse link
G Bag6 BAG cochaperone 6 ISO (MGI:3808636|PMID:18678708) UniProt PMID:18678708 MGI:3808636 NCBI chrNW_004955437:176,848...188,243
Ensembl chrNW_004955437:176,797...188,003
JBrowse link
G Camlg calcium modulating ligand ISO (PMID:20553626) UniProt PMID:20553626 NCBI chrNW_004955408:29,968,962...29,977,896
Ensembl chrNW_004955408:29,968,934...29,979,794
JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 ISO (PMID:23398316) UniProtKB PMID:23398316 NCBI chrNW_004955403:46,027,997...46,042,154
Ensembl chrNW_004955403:46,027,998...46,042,154
JBrowse link
G Clec16a C-type lectin domain containing 16A ISO (MGI:5603233|PMID:24949970) MGI PMID:24949970 MGI:5603233 NCBI chrNW_004955442:7,369,616...7,584,052
Ensembl chrNW_004955442:7,368,952...7,584,703
JBrowse link
G Ddrgk1 DDRGK domain containing 1 ISO (PMID:28263186) UniProtKB PMID:28263186 NCBI chrNW_004955415:14,085,404...14,098,220
Ensembl chrNW_004955415:14,085,404...14,098,856
JBrowse link
G Eif3h eukaryotic translation initiation factor 3 subunit H ISO (PMID:32269044) FlyBase PMID:32269044 NCBI chrNW_004955417:22,757,781...22,846,349
Ensembl chrNW_004955417:22,754,395...22,846,618
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO (PMID:15313915) UniProtKB PMID:15313915 NCBI chrNW_004955430:221,518...508,094 JBrowse link
G Gipc1 GIPC PDZ domain containing family member 1 ISO (MGI:3807767|PMID:11546783) BHF-UCL PMID:11546783 MGI:3807767 NCBI chrNW_004955415:33,067,689...33,077,749
Ensembl chrNW_004955415:33,067,689...33,074,730
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO (PMID:16280321)
(PMID:24613385)
MGI
UniProtKB
PMID:16280321, PMID:24613385 NCBI chrNW_004955437:9,872,649...9,878,459
Ensembl chrNW_004955437:9,873,908...9,878,459
JBrowse link
G Klhl40 kelch like family member 40 ISO (MGI:5586592|PMID:24960163) MGI PMID:24960163 MGI:5586592 NCBI chrNW_004955420:28,117,553...28,122,391
Ensembl chrNW_004955420:28,117,898...28,122,270
JBrowse link
G Map1a microtubule associated protein 1A ISO (MGI:5703671|PMID:26609151) ARUK-UCL PMID:26609151 MGI:5703671 NCBI chrNW_004955416:10,052,964...10,073,318
Ensembl chrNW_004955416:10,053,010...10,071,421
JBrowse link
G Mtm1 myotubularin 1 ISO (MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:5510937 NCBI chrNW_004955498:6,329,402...6,444,708
Ensembl chrNW_004955498:6,329,275...6,445,169
JBrowse link
G N4bp1 NEDD4 binding protein 1 ISO (MGI:3829128|PMID:17592138) UniProt PMID:17592138 MGI:3829128 NCBI chrNW_004955474:6,796,068...6,814,906
Ensembl chrNW_004955474:6,796,066...6,814,906
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:22522597) UniProtKB PMID:22522597 NCBI chrNW_004955574:1,505,997...1,514,680
Ensembl chrNW_004955574:1,506,022...1,517,130
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO (PMID:26678539) UniProtKB PMID:26678539 NCBI chrNW_004955475:11,062,258...11,112,252
Ensembl chrNW_004955475:11,062,076...11,114,169
JBrowse link
G Park7 Parkinsonism associated deglycase ISO (PMID:17015834) ParkinsonsUK-UCL PMID:17015834 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885
JBrowse link
G Pbk PDZ binding kinase ISO (MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:5293269 NCBI chrNW_004955403:50,332,167...50,353,147
Ensembl chrNW_004955403:50,330,981...50,352,570
JBrowse link
G Rpl11 ribosomal protein L11 ISO (MGI:5897550|PMID:21804542) UniProt PMID:21804542 MGI:5897550 NCBI chrNW_004955452:3,626,609...3,630,911
Ensembl chrNW_004955452:3,626,609...3,633,209
JBrowse link
G Rybp RING1 and YY1 binding protein ISO (PMID:27060496) UniProtKB PMID:27060496 NCBI chrNW_004955421:15,728,778...15,803,150
Ensembl chrNW_004955421:15,728,580...15,803,150
JBrowse link
G Sdcbp syndecan binding protein ISO (PMID:25893292) UniProtKB PMID:25893292 NCBI chrNW_004955454:17,093,930...17,113,491
Ensembl chrNW_004955454:17,089,232...17,113,484
JBrowse link
G Senp1 SUMO specific peptidase 1 ISO (MGI:3818351|PMID:17981124) MGI PMID:17981124 MGI:3818351 NCBI chrNW_004955500:6,924,445...6,978,482
Ensembl chrNW_004955500:6,926,548...6,979,230
JBrowse link
G Shh sonic hedgehog signaling molecule ISO (MGI:3624046|PMID:16611981) MGI PMID:16611981 MGI:3624046 NCBI chrNW_004955491:8,647,133...8,657,381 JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 ISO (MGI:5310666|PMID:22285184) MGI PMID:22285184 MGI:5310666 NCBI chrNW_004955420:24,594,057...24,729,108
Ensembl chrNW_004955420:24,593,830...24,729,108
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 ISO (PMID:11278372) BHF-UCL PMID:11278372 NCBI chrNW_004955575:74,506...76,272
Ensembl chrNW_004955575:74,506...76,272
JBrowse link
G Tlk2 tousled like kinase 2 ISO (PMID:20016786) UniProtKB PMID:20016786 NCBI chrNW_004955478:9,100,863...9,229,448
Ensembl chrNW_004955478:9,100,863...9,231,281
JBrowse link
G Ttc36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chrNW_004955412:19,670,590...19,672,495 JBrowse link
G Ubxn1 UBX domain protein 1 ISO (PMID:20351172) UniProtKB PMID:20351172 NCBI chrNW_004955599:526,792...529,825
Ensembl chrNW_004955599:526,966...529,735
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 ISO (PMID:23770237) UniProtKB PMID:23770237 NCBI chrNW_004955406:30,432,652...30,468,741 JBrowse link
G Usp7 ubiquitin specific peptidase 7 ISO (PMID:26678539) UniProtKB PMID:26678539 NCBI chrNW_004955442:9,316,022...9,355,751
Ensembl chrNW_004955442:9,315,225...9,356,393
JBrowse link
G Wac WW domain containing adaptor with coiled-coil ISO (PMID:22354037) BHF-UCL PMID:22354037 NCBI chrNW_004955462:2,358,842...2,435,644
Ensembl chrNW_004955462:2,358,842...2,435,628
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Styx serine/threonine/tyrosine interacting protein ISO (PMID:28007894) UniProtKB PMID:28007894 NCBI chrNW_004955409:10,428,556...10,445,384
Ensembl chrNW_004955409:10,428,556...10,445,880
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anks1a ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:4461099 NCBI chrNW_004955437:2,916,598...3,070,771
Ensembl chrNW_004955437:2,916,598...3,070,771
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chrNW_004955597:326,601...397,112 JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chrNW_004955433:15,677,788...15,718,894
Ensembl chrNW_004955433:15,674,116...15,718,894
JBrowse link
G Hfe homeostatic iron regulator ISO (PMID:24904118) BHF-UCL PMID:24904118 NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO (PMID:21628596) FlyBase PMID:21628596 NCBI chrNW_004955494:3,365,826...3,554,735
Ensembl chrNW_004955494:3,393,049...3,554,844
JBrowse link
G Pdcl3 phosducin like 3 ISO (PMID:23792958) MGI PMID:23792958 NCBI chrNW_004955470:6,553,450...6,563,814 JBrowse link
G Pml PML nuclear body scaffold ISO (PMID:15195100) UniProtKB PMID:15195100 NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406
JBrowse link
G Psen1 presenilin 1 ISO (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737
JBrowse link
G Psen2 presenilin 2 ISO (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234
JBrowse link
G Qrich2 glutamine rich 2 ISO (PMID:30683861)
(MGI:6277293|PMID:30683861)
UniProt PMID:30683861 MGI:6277293 NCBI chrNW_004955506:5,990,070...6,015,808 JBrowse link
G Rpl11 ribosomal protein L11 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chrNW_004955452:3,626,609...3,630,911
Ensembl chrNW_004955452:3,626,609...3,633,209
JBrowse link
G Rpl23 ribosomal protein L23 ISO (PMID:15314173) CAFA PMID:15314173 NCBI chrNW_004955451:13,892,880...13,898,079
Ensembl chrNW_004955451:13,892,880...13,898,079
JBrowse link
G Rpl5 ribosomal protein L5 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chrNW_004955423:1,748,809...1,758,622 JBrowse link
G Rps7 ribosomal protein S7 ISO (PMID:17310983) CAFA PMID:17310983 NCBI chrNW_004955487:3,793,168...3,798,007
Ensembl chrNW_004955487:3,792,870...3,798,153
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chrNW_004955495:5,025,038...5,051,810
Ensembl chrNW_004955495:5,031,229...5,052,389
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004955485:7,805,244...7,925,414
Ensembl chrNW_004955485:7,808,131...7,925,677
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 ISO (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chrNW_004955475:10,930,175...11,006,876 JBrowse link
G Wnt1 Wnt family member 1 ISO (MGI:3628833|PMID:16601693) MGI PMID:16601693 MGI:3628833 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7608
      primary metabolic process 6749
        protein metabolic process 3854
          proteolysis 1059
            negative regulation of proteolysis 210
              negative regulation of proteolysis involved in cellular protein catabolic process 65
                negative regulation of proteasomal protein catabolic process + 47
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 51
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8725
      regulation of biological process 8270
        regulation of metabolic process 5040
          regulation of macromolecule metabolic process 4632
            regulation of protein metabolic process 2280
              regulation of protein catabolic process 356
                negative regulation of protein catabolic process 122
                  negative regulation of cellular protein catabolic process 78
                    negative regulation of proteolysis involved in cellular protein catabolic process 65
                      negative regulation of proteasomal protein catabolic process + 47
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.