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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EFNA1 ephrin A1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,373,197...42,381,161
Ensembl chr 7:42,373,639...42,378,946
JBrowse link
G EPHA4 EPH receptor A4 IEA Ensembl GO_REF:0000107 NCBI chr37:27,670,143...27,809,642
Ensembl chr37:27,677,566...27,809,646
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SGTA small glutamine rich tetratricopeptide repeat containing alpha IEA Ensembl GO_REF:0000107 NCBI chr20:56,432,688...56,451,438
Ensembl chr20:56,441,724...56,450,215
JBrowse link
G SVIP small VCP interacting protein ISO (PMID:17872946) UniProtKB PMID:17872946 NCBI chr21:44,408,467...44,418,160
Ensembl chr21:44,408,474...44,415,739
JBrowse link
G USP14 ubiquitin specific peptidase 14 IEA Ensembl GO_REF:0000107 NCBI chr 7:67,035,774...67,080,082
Ensembl chr 7:67,035,843...67,079,465
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP11 aquaporin 11 IEA Ensembl GO_REF:0000107 NCBI chr21:21,170,760...21,185,709
Ensembl chr21:21,171,008...21,185,429
JBrowse link
G UBXN1 UBX domain protein 1 IEA Ensembl GO_REF:0000107 NCBI chr18:53,977,937...53,982,108
Ensembl chr18:53,978,062...53,982,111
JBrowse link
G USP25 ubiquitin specific peptidase 25 IEA Ensembl GO_REF:0000107 NCBI chr31:12,555,614...12,692,765
Ensembl chr31:12,555,595...12,691,694
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase IEA Ensembl GO_REF:0000107 NCBI chr11:67,736,643...67,752,399
Ensembl chr11:67,741,390...67,752,321
JBrowse link
G F8A1 coagulation factor VIII associated 1 ISO (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:122,914,362...122,916,199 JBrowse link
G GABARAPL2 GABA type A receptor associated protein like 2 IEA Ensembl GO_REF:0000107 NCBI chr 5:75,230,214...75,240,724
Ensembl chr 5:75,230,243...75,240,730
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO PMID:17517623
(MGI:6148636|PMID:17517623)
ARUK-UCL PMID:17517623 MGI:6148636, RGD:13514081 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link
G LAMP3 lysosomal associated membrane protein 3 ISO (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chr34:16,092,172...16,126,563 JBrowse link
G LOC484316 protein kinase C gamma type IEA Ensembl GO_REF:0000107 NCBI chr 1:103,495,013...103,512,465 JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IEA Ensembl GO_REF:0000107 NCBI chr36:5,481,449...5,533,139
Ensembl chr36:5,481,456...5,531,957
JBrowse link
G OPHN1 oligophrenin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:52,418,390...52,983,155
Ensembl chr  X:52,455,373...52,982,244
JBrowse link
G PRKCG protein kinase C gamma IEA Ensembl GO_REF:0000107 NCBI chr 1:103,295,110...103,312,562 JBrowse link
G PSME3IP1 proteasome activator subunit 3 interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:59,185,238...59,220,515
Ensembl chr 2:59,186,349...59,220,515
JBrowse link
G PSMF1 proteasome inhibitor subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr24:19,817,104...19,863,632
Ensembl chr24:19,819,055...19,859,586
JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:34,957,358...34,971,684
Ensembl chr 5:34,957,785...34,971,661
JBrowse link
G USP19 ubiquitin specific peptidase 19 IEA Ensembl GO_REF:0000107 NCBI chr20:40,062,802...40,074,221
Ensembl chr20:40,064,599...40,074,082
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG5 BAG cochaperone 5 IEA Ensembl GO_REF:0000107 NCBI chr 8:71,318,730...71,324,743
Ensembl chr 8:71,321,625...71,322,992
JBrowse link
G BAG6 BAG cochaperone 6 ISO (MGI:3808636|PMID:18678708) UniProt PMID:18678708 MGI:3808636 NCBI chr12:1,126,730...1,141,978
Ensembl chr12:1,126,732...1,137,896
JBrowse link
G CAMLG calcium modulating ligand IEA Ensembl GO_REF:0000107 NCBI chr11:22,818,699...22,829,737
Ensembl chr11:22,818,743...22,829,736
JBrowse link
G CCAR2 cell cycle and apoptosis regulator 2 IEA Ensembl GO_REF:0000107 NCBI chr25:34,660,026...34,674,129
Ensembl chr25:34,660,553...34,674,037
JBrowse link
G CLEC16A C-type lectin domain containing 16A IEA Ensembl GO_REF:0000107 NCBI chr 6:31,560,940...31,757,100
Ensembl chr 6:31,562,834...31,757,678
JBrowse link
G DDRGK1 DDRGK domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr24:18,085,865...18,098,868
Ensembl chr24:18,084,725...18,097,157
JBrowse link
G EIF3H eukaryotic translation initiation factor 3 subunit H ISO (PMID:32269044) FlyBase PMID:32269044 NCBI chr13:16,105,960...16,201,902
Ensembl chr13:16,105,990...16,341,153
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase IEA Ensembl GO_REF:0000107 NCBI chr20:29,735,380...31,113,859
Ensembl chr20:30,356,572...31,113,859
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 IEA Ensembl GO_REF:0000107 NCBI chr20:48,144,076...48,155,069
Ensembl chr20:48,150,498...48,157,191
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link
G KLHL40 kelch like family member 40 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:11,812,268...11,820,426
Ensembl chr23:11,813,550...11,820,420
JBrowse link
G LOC102154748 E3 ubiquitin-protein ligase TRIM39 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:317,149...330,907
Ensembl chr12:319,413...329,427
JBrowse link
G MAP1A microtubule associated protein 1A ISO (MGI:5703671|PMID:26609151) ARUK-UCL PMID:26609151 MGI:5703671 NCBI chr30:10,361,871...10,382,780
Ensembl chr30:10,361,909...10,381,376
JBrowse link
G MTM1 myotubularin 1 ISO (MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:5510937 NCBI chr  X:118,820,644...118,917,166
Ensembl chr  X:118,820,494...118,916,368
JBrowse link
G N4BP1 NEDD4 binding protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:66,544,665...66,565,858
Ensembl chr 2:66,544,677...66,561,560
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IEA Ensembl GO_REF:0000107 NCBI chr 1:108,307,039...108,315,732
Ensembl chr 1:108,307,042...108,316,495
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase IEA Ensembl GO_REF:0000107 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502
JBrowse link
G PARK7 Parkinsonism associated deglycase ISO (PMID:17015834) ParkinsonsUK-UCL PMID:17015834 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr25:29,751,805...29,781,806
Ensembl chr25:29,751,848...29,781,300
JBrowse link
G RPL11 ribosomal protein L11 IEA Ensembl GO_REF:0000107 NCBI chr 2:75,781,210...75,785,614
Ensembl chr 2:75,781,091...75,785,605
JBrowse link
G RYBP RING1 and YY1 binding protein IEA Ensembl GO_REF:0000107 NCBI chr20:19,650,936...19,732,987
Ensembl chr20:19,615,426...19,729,474
JBrowse link
G SDCBP syndecan binding protein ISO (PMID:25893292) UniProtKB PMID:25893292 NCBI chr29:9,331,876...9,370,489 JBrowse link
G SENP1 SUMO specific peptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr27:6,664,750...6,719,257
Ensembl chr27:6,664,818...6,714,479
JBrowse link
G SHH sonic hedgehog signaling molecule IEA Ensembl GO_REF:0000107 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903
JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 IEA Ensembl GO_REF:0000107 NCBI chr20:41,165,593...41,337,237
Ensembl chr20:41,165,522...41,335,917
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 IEA Ensembl GO_REF:0000107 NCBI chr 2:54,403,908...54,406,857
Ensembl chr 2:54,390,411...54,406,872
JBrowse link
G TLK2 tousled like kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr 9:10,686,424...10,804,885
Ensembl chr 9:10,687,293...10,803,963
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr 5:15,207,400...15,211,905
Ensembl chr 5:15,207,403...15,211,853
JBrowse link
G UBXN1 UBX domain protein 1 IEA Ensembl GO_REF:0000107 NCBI chr18:53,977,937...53,982,108
Ensembl chr18:53,978,062...53,982,111
JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 ISO (PMID:23770237) UniProtKB PMID:23770237 NCBI chr38:6,004,595...6,045,999
Ensembl chr38:6,004,659...6,113,714
JBrowse link
G USP7 ubiquitin specific peptidase 7 IEA Ensembl GO_REF:0000107 NCBI chr 6:33,277,328...33,315,601
Ensembl chr 6:33,277,444...33,314,491
JBrowse link
G WAC WW domain containing adaptor with coiled-coil ISO (PMID:22354037) BHF-UCL PMID:22354037 NCBI chr 2:17,504,949...17,588,037 JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STYX serine/threonine/tyrosine interacting protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:28,949,732...28,990,455
Ensembl chr 8:28,950,061...28,986,812
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:4461099 NCBI chr12:4,095,394...4,274,428
Ensembl chr12:4,095,490...4,272,654
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr24:20,333,593...20,390,341 JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr 2:58,361,328...58,441,701
Ensembl chr 2:58,360,838...58,432,371
JBrowse link
G HFE homeostatic iron regulator IEA Ensembl GO_REF:0000107 NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr16:9,066,957...9,256,916
Ensembl chr16:9,066,970...9,244,526
JBrowse link
G LOC102154748 E3 ubiquitin-protein ligase TRIM39 ISO (PMID:19100260) BHF-UCL PMID:19100260 NCBI chr12:317,149...330,907
Ensembl chr12:319,413...329,427
JBrowse link
G PDCL3 phosducin like 3 IEA Ensembl GO_REF:0000107 NCBI chr10:42,214,127...42,223,986
Ensembl chr10:42,215,120...42,223,906
JBrowse link
G PML PML nuclear body scaffold IEA Ensembl GO_REF:0000107 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741
JBrowse link
G PSEN1 presenilin 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532
JBrowse link
G PSEN2 presenilin 2 ISO (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
G QRICH2 glutamine rich 2 ISO (PMID:30683861)
(MGI:6277293|PMID:30683861)
UniProt PMID:30683861 MGI:6277293 NCBI chr 9:4,395,501...4,408,302
Ensembl chr 9:4,374,650...4,408,299
JBrowse link
G RPL11 ribosomal protein L11 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 2:75,781,210...75,785,614
Ensembl chr 2:75,781,091...75,785,605
JBrowse link
G RPL23 ribosomal protein L23 IEA Ensembl GO_REF:0000107 NCBI chr 9:23,397,143...23,403,060
Ensembl chr 9:23,262,282...23,403,054
JBrowse link
G RPL5 ribosomal protein L5 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 6:56,207,171...56,216,030
Ensembl chr 6:56,207,173...56,215,956
JBrowse link
G RPS7 ribosomal protein S7 ISO (PMID:17310983) CAFA PMID:17310983 NCBI chr17:2,139,011...2,143,160
Ensembl chr17:2,138,779...2,143,178
JBrowse link
G SGTA small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chr20:56,432,688...56,451,438
Ensembl chr20:56,441,724...56,450,215
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389
JBrowse link
G TAF1 TATA-box binding protein associated factor 1 ISO (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chr  X:55,693,091...55,764,268 JBrowse link
G WNT1 Wnt family member 1 ISO (MGI:3628833|PMID:16601693) MGI PMID:16601693 MGI:3628833 NCBI chr27:5,588,151...5,592,254
Ensembl chr27:5,574,940...5,592,060
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    metabolic process 10657
      primary metabolic process 9458
        protein metabolic process 5384
          proteolysis 1651
            negative regulation of proteolysis 331
              negative regulation of proteolysis involved in cellular protein catabolic process 68
                negative regulation of proteasomal protein catabolic process + 50
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 52
Path 2
Term Annotations click to browse term
  biological_process 16190
    biological regulation 11558
      regulation of biological process 10960
        regulation of metabolic process 6410
          regulation of macromolecule metabolic process 5943
            regulation of protein metabolic process 2749
              regulation of protein catabolic process 394
                negative regulation of protein catabolic process 126
                  negative regulation of cellular protein catabolic process 81
                    negative regulation of proteolysis involved in cellular protein catabolic process 68
                      negative regulation of proteasomal protein catabolic process + 50
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.