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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A IMP (PMID:25217637) ParkinsonsUK-UCL PMID:25217637 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G EFNA1 ephrin A1 IGI (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899
JBrowse link
G EPHA4 EPH receptor A4 IGI (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SGTA small glutamine rich tetratricopeptide repeat containing alpha IDA (PMID:23129660) UniProtKB PMID:23129660 NCBI chr19:2,754,714...2,783,317
Ensembl chr19:2,754,715...2,783,282
JBrowse link
G SVIP small VCP interacting protein IMP
IBA
(PMID:17872946)
(PMID:21873635)
UniProtKB
GO_Central
PMID:17872946, PMID:21873635 NCBI chr11:22,812,429...22,829,865
Ensembl chr11:22,813,799...22,830,299
JBrowse link
G USP14 ubiquitin specific peptidase 14 IMP (PMID:19135427) ParkinsonsUK-UCL PMID:19135427 NCBI chr18:158,557...214,629
Ensembl chr18:158,383...214,629
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP11 aquaporin 11 ISS UniProt GO_REF:0000024 NCBI chr11:77,589,953...77,610,356
Ensembl chr11:77,589,391...77,610,356
JBrowse link
G UBXN1 UBX domain protein 1 IMP (PMID:21135095) ParkinsonsUK-UCL PMID:21135095 NCBI chr11:62,676,500...62,679,116
Ensembl chr11:62,676,498...62,679,117
JBrowse link
G USP25 ubiquitin specific peptidase 25 IMP (PMID:22590560) ParkinsonsUK-UCL PMID:22590560 NCBI chr21:15,729,947...15,880,064
Ensembl chr21:15,730,025...15,880,069
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase IDA (PMID:8175643) CAFA PMID:8175643 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G F8A1 coagulation factor VIII associated 1 IMP (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:154,886,360...154,888,061
Ensembl chr  X:154,886,349...154,888,061
JBrowse link
G F8A2 coagulation factor VIII associated 2 IMP (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:155,382,115...155,383,230
Ensembl chr  X:155,382,115...155,383,230
JBrowse link
G F8A3 coagulation factor VIII associated 3 IMP (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:155,456,914...155,458,620
Ensembl chr  X:155,456,914...155,458,672
Ensembl chr  X:155,456,914...155,458,672
JBrowse link
G GABARAPL2 GABA type A receptor associated protein like 2 IMP (PMID:21669198) BHF-UCL PMID:21669198 NCBI chr16:75,566,379...75,577,881
Ensembl chr16:75,566,375...75,577,881
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISS (PMID:17517623) ARUK-UCL PMID:17517623 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G LAMP3 lysosomal associated membrane protein 3 IMP (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chr 3:183,122,215...183,162,761
Ensembl chr 3:183,122,215...183,163,839
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IMP (PMID:29295817) UniProtKB PMID:29295817 NCBI chr 2:159,712,494...159,771,027
Ensembl chr 2:159,712,457...159,771,027
JBrowse link
G OPHN1 oligophrenin 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:68,042,344...68,433,841
Ensembl chr  X:68,042,344...68,433,913
JBrowse link
G PRKCG protein kinase C gamma ISS UniProtKB GO_REF:0000024 NCBI chr19:53,882,197...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
G PSME3IP1 proteasome activator subunit 3 interacting protein 1 IMP (PMID:29934401) UniProt PMID:29934401 NCBI chr16:57,152,466...57,186,116
Ensembl chr16:57,152,466...57,186,116
JBrowse link
G PSMF1 proteasome inhibitor subunit 1 IDA (PMID:10764772) UniProtKB PMID:10764772 NCBI chr20:1,113,263...1,172,246
Ensembl chr20:1,113,240...1,189,415
JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 IEA Ensembl GO_REF:0000107 NCBI chr17:10,672,474...10,697,533
Ensembl chr17:10,672,474...10,698,375
JBrowse link
G USP19 ubiquitin specific peptidase 19 IEA Ensembl GO_REF:0000107 NCBI chr 3:49,108,050...49,120,933
Ensembl chr 3:49,108,046...49,120,938
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG5 BAG cochaperone 5 IDA (PMID:24475098) ParkinsonsUK-UCL PMID:24475098 NCBI chr14:103,556,551...103,562,657
Ensembl chr14:103,556,544...103,562,831
JBrowse link
G BAG6 BAG cochaperone 6 ISS UniProtKB GO_REF:0000024 NCBI chr 6:31,639,028...31,660,900
Ensembl chr 6:31,639,028...31,652,705
JBrowse link
G CAMLG calcium modulating ligand IMP (PMID:20553626) UniProt PMID:20553626 NCBI chr 5:134,738,548...134,752,157
Ensembl chr 5:134,738,548...134,752,157
JBrowse link
G CCAR2 cell cycle and apoptosis regulator 2 IDA (PMID:23398316) UniProtKB PMID:23398316 NCBI chr 8:22,604,740...22,621,514
Ensembl chr 8:22,604,632...22,621,514
JBrowse link
G CLEC16A C-type lectin domain containing 16A IEA Ensembl GO_REF:0000107 NCBI chr16:10,944,539...11,193,272
Ensembl chr16:10,944,564...11,182,186
JBrowse link
G DDRGK1 DDRGK domain containing 1 IMP (PMID:28263186) UniProtKB PMID:28263186 NCBI chr20:3,190,350...3,204,682
Ensembl chr20:3,190,350...3,204,685
JBrowse link
G EIF3H eukaryotic translation initiation factor 3 subunit H IDA (PMID:32269044) FlyBase PMID:32269044 NCBI chr 8:116,642,130...116,755,823
Ensembl chr 8:116,642,130...116,766,925
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase IMP
IBA
(PMID:15313915)
(PMID:21873635)
UniProtKB
GO_Central
PMID:15313915, PMID:21873635 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 ISS BHF-UCL GO_REF:0000024 NCBI chr19:14,477,761...14,496,133
Ensembl chr19:14,477,760...14,496,149
JBrowse link
G HFE homeostatic iron regulator IC (PMID:24904118) BHF-UCL PMID:24904118 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IMP
IDA
(PMID:16280321)
(PMID:24613385)
MGI
UniProtKB
PMID:16280321, PMID:24613385 NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888
JBrowse link
G KLHL40 kelch like family member 40 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:42,685,537...42,692,544
Ensembl chr 3:42,685,537...42,692,544
JBrowse link
G MAP1A microtubule associated protein 1A ISS ARUK-UCL GO_REF:0000024 NCBI chr15:43,517,608...43,531,611
Ensembl chr15:43,510,958...43,531,620
JBrowse link
G MTM1 myotubularin 1 ISO (MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:5510937 NCBI chr  X:150,562,658...150,673,143
Ensembl chr  X:150,568,619...150,673,322
Ensembl chr  X:150,568,619...150,673,322
JBrowse link
G N4BP1 NEDD4 binding protein 1 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr16:48,538,726...48,610,214
Ensembl chr16:48,538,726...48,620,148
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IMP (PMID:22522597) UniProtKB PMID:22522597 NCBI chr19:47,745,546...47,757,058
Ensembl chr19:47,745,546...47,757,058
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase IMP (PMID:26678539) UniProtKB PMID:26678539 NCBI chr  X:71,533,104...71,575,892
Ensembl chr  X:71,533,104...71,575,892
JBrowse link
G PANO1 proapoptotic nucleolar protein 1 IMP (PMID:22094112) UniProtKB PMID:22094112 NCBI chr11:796,633...799,179
Ensembl chr11:797,511...799,185
JBrowse link
G PARK7 Parkinsonism associated deglycase IDA (PMID:17015834) ParkinsonsUK-UCL PMID:17015834 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr 8:27,809,624...27,837,817
Ensembl chr 8:27,809,624...27,838,082
JBrowse link
G RPL11 ribosomal protein L11 ISS UniProtKB GO_REF:0000024 NCBI chr 1:23,691,779...23,696,835
Ensembl chr 1:23,691,742...23,696,835
JBrowse link
G RYBP RING1 and YY1 binding protein IMP (PMID:27060496) UniProtKB PMID:27060496 NCBI chr 3:72,374,593...72,446,623
Ensembl chr 3:72,371,825...72,446,621
JBrowse link
G SDCBP syndecan binding protein IMP (PMID:25893292) UniProtKB PMID:25893292 NCBI chr 8:58,553,261...58,582,860
Ensembl chr 8:58,552,924...58,582,859
JBrowse link
G SENP1 SUMO specific peptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr12:48,042,893...48,106,308
Ensembl chr12:48,042,897...48,106,079
JBrowse link
G SHH sonic hedgehog signaling molecule IEA Ensembl GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:47,585,269...47,781,893
Ensembl chr 3:47,585,269...47,782,106
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 IDA (PMID:11278372) BHF-UCL PMID:11278372 NCBI chr 5:69,364,743...69,369,824
Ensembl chr 5:69,364,743...69,370,013
JBrowse link
G TLK2 tousled like kinase 2 IMP (PMID:20016786) UniProtKB PMID:20016786 NCBI chr17:62,470,908...62,615,481
Ensembl chr17:62,458,658...62,615,481
JBrowse link
G TRIM39 tripartite motif containing 39 IMP
IBA
(PMID:23213251)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:23213251 NCBI chr 6:30,326,469...30,343,729
Ensembl chr 6:30,326,479...30,343,729
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr11:118,527,474...118,530,993
Ensembl chr11:118,527,472...118,531,197
JBrowse link
G UBXN1 UBX domain protein 1 IDA (PMID:20351172) UniProtKB PMID:20351172 NCBI chr11:62,676,500...62,679,116
Ensembl chr11:62,676,498...62,679,117
JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 IMP (PMID:23770237) UniProtKB PMID:23770237 NCBI chr 1:193,012,254...193,060,140
Ensembl chr 1:193,012,250...193,060,080
JBrowse link
G USP7 ubiquitin specific peptidase 7 IMP (PMID:26678539) UniProtKB PMID:26678539 NCBI chr16:8,892,097...8,963,912
Ensembl chr16:8,892,097...8,975,328
Ensembl chr16:8,892,097...8,975,328
JBrowse link
G WAC WW domain containing adaptor with coiled-coil IMP (PMID:22354037) BHF-UCL PMID:22354037 NCBI chr10:28,532,772...28,623,112
Ensembl chr10:28,532,493...28,623,112
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STYX serine/threonine/tyrosine interacting protein IMP
IBA
(PMID:28007894)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:28007894 NCBI chr14:52,730,159...52,774,989
Ensembl chr14:52,730,166...52,774,989
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:4461099 NCBI chr 6:34,889,255...35,097,992
Ensembl chr 6:34,889,255...35,091,406
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A IDA (PMID:16173922), (PMID:18560357) CAFA PMID:16173922, PMID:18560357 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 IGI (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835
JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 IGI (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106
JBrowse link
G HFE homeostatic iron regulator IDA (PMID:24904118) BHF-UCL PMID:24904118 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 IMP (PMID:21628596) FlyBase PMID:21628596 NCBI chr 7:139,561,570...139,777,998
Ensembl chr 7:139,561,570...139,777,998
JBrowse link
G PDCL3 phosducin like 3 IMP (PMID:23792958) MGI PMID:23792958 NCBI chr 2:100,562,993...100,577,472
Ensembl chr 2:100,562,993...100,576,739
JBrowse link
G PML PML nuclear body scaffold IMP (PMID:15195100) UniProtKB PMID:15195100 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827
JBrowse link
G PSEN1 presenilin 1 IEA Ensembl GO_REF:0000107 NCBI chr14:73,136,436...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PSEN2 presenilin 2 ISO (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chr 1:226,870,594...226,903,829
Ensembl chr 1:226,870,184...226,896,105
JBrowse link
G QRICH2 glutamine rich 2 IMP (PMID:30683861) UniProt PMID:30683861 NCBI chr17:76,271,296...76,308,811
Ensembl chr17:76,274,049...76,307,998
JBrowse link
G RPL11 ribosomal protein L11 IMP (PMID:18560357) CAFA PMID:18560357 NCBI chr 1:23,691,779...23,696,835
Ensembl chr 1:23,691,742...23,696,835
JBrowse link
G RPL23 ribosomal protein L23 IDA (PMID:15314173) CAFA PMID:15314173 NCBI chr17:38,847,860...38,853,721
Ensembl chr17:38,847,860...38,853,764
JBrowse link
G RPL5 ribosomal protein L5 IDA (PMID:18560357) CAFA PMID:18560357 NCBI chr 1:92,831,986...92,841,924
Ensembl chr 1:92,832,013...92,841,924
JBrowse link
G RPS7 ribosomal protein S7 IDA (PMID:17310983) CAFA PMID:17310983 NCBI chr 2:3,575,260...3,580,920
Ensembl chr 2:3,575,260...3,580,920
JBrowse link
G SGTA small glutamine rich tetratricopeptide repeat containing alpha IDA (PMID:23129660) UniProtKB PMID:23129660 NCBI chr19:2,754,714...2,783,317
Ensembl chr19:2,754,715...2,783,282
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr10:102,502,801...102,633,535
Ensembl chr10:102,503,987...102,633,535
Ensembl chr10:102,503,987...102,633,535
JBrowse link
G TAF1 TATA-box binding protein associated factor 1 IMP (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chr  X:71,366,220...71,530,525
Ensembl chr  X:71,366,264...71,532,374
Ensembl chr  X:71,366,264...71,532,374
JBrowse link
G TRIM39 tripartite motif containing 39 IDA (PMID:19100260) BHF-UCL PMID:19100260 NCBI chr 6:30,326,469...30,343,729
Ensembl chr 6:30,326,479...30,343,729
JBrowse link
G WNT1 Wnt family member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18672
    metabolic process 12302
      primary metabolic process 10998
        protein metabolic process 6161
          proteolysis 1904
            negative regulation of proteolysis 381
              negative regulation of proteolysis involved in cellular protein catabolic process 71
                negative regulation of proteasomal protein catabolic process + 53
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 54
Path 2
Term Annotations click to browse term
  biological_process 18672
    biological regulation 13310
      regulation of biological process 12642
        regulation of metabolic process 7546
          regulation of macromolecule metabolic process 6987
            regulation of protein metabolic process 3039
              regulation of protein catabolic process 423
                negative regulation of protein catabolic process 134
                  negative regulation of cellular protein catabolic process 85
                    negative regulation of proteolysis involved in cellular protein catabolic process 71
                      negative regulation of proteasomal protein catabolic process + 53
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 54
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.