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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin dependent kinase inhibitor 2A IDA
ISO
(MGI:5468878|PMID:23277542) MGI PMID:23277542 GO_REF:0000096, MGI:4834177, MGI:5468878 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Efna1 ephrin A1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 3:89,271,730...89,280,951
Ensembl chr 3:89,271,733...89,281,142
JBrowse link
G Epha4 Eph receptor A4 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:77,367,182...77,515,107
Ensembl chr 1:77,367,185...77,515,088
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr10:81,044,071...81,060,271
Ensembl chr10:81,044,075...81,060,181
JBrowse link
G Svip small VCP/p97-interacting protein IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 7:51,997,161...52,006,018
Ensembl chr 7:51,997,171...52,006,018
JBrowse link
G Usp14 ubiquitin specific peptidase 14 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr18:9,993,615...10,030,149
Ensembl chr18:9,993,066...10,045,119
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 IMP (MGI:3813160|PMID:18606867) UniProt PMID:18606867 MGI:3813160 NCBI chr 7:97,726,379...97,738,247
Ensembl chr 7:97,724,006...97,738,289
JBrowse link
G Ubxn1 UBX domain protein 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr19:8,871,548...8,875,666
Ensembl chr19:8,871,496...8,875,863
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr16:77,013,684...77,116,783
Ensembl chr16:77,013,706...77,116,780
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate, delta-, dehydratase ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G F8a factor 8-associated gene A ISO (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:73,228,306...73,230,795
Ensembl chr  X:73,228,291...73,230,795
JBrowse link
G Gabarapl2 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:111,940,703...111,952,915
Ensembl chr 8:111,940,703...111,953,612
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 ISO
IMP
(MGI:6148636|PMID:17517623) MGI
ARUK-UCL
PMID:17517623 GO_REF:0000096, MGI:4417868, MGI:6148636 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr16:19,653,381...19,706,365
Ensembl chr16:19,653,378...19,706,375
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:60,209,936...60,248,385
Ensembl chr 2:60,209,887...60,250,676
JBrowse link
G Ophn1 oligophrenin 1 IDA
IBA
(MGI:5303043|PMID:21874017)
(MGI:6201960|PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:21874017 MGI:5303043, MGI:6201960 NCBI chr  X:98,554,280...98,891,082
Ensembl chr  X:98,554,277...98,891,025
JBrowse link
G Prkcg protein kinase C, gamma IMP (MGI:5467682|PMID:23185022) UniProt PMID:23185022 MGI:5467682 NCBI chr 7:3,303,532...3,331,099
Ensembl chr 7:3,289,179...3,331,099
JBrowse link
G Psme3ip1 proteasome activator subunit 3 interacting protein 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:94,574,940...94,601,962
Ensembl chr 8:94,574,138...94,601,997
JBrowse link
G Psmf1 proteasome (prosome, macropain) inhibitor subunit 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:151,716,062...151,744,199
Ensembl chr 2:151,715,812...151,744,186
JBrowse link
G Sco1 SCO1 cytochrome c oxidase assembly protein IMP (MGI:5643882|PMID:25683716) MGI PMID:25683716 MGI:5643882 NCBI chr11:67,052,600...67,067,444
Ensembl chr11:67,052,670...67,067,070
JBrowse link
G Usp19 ubiquitin specific peptidase 19 IDA (MGI:5614537|PMID:25088257) ParkinsonsUK-UCL PMID:25088257 MGI:5614537 NCBI chr 9:108,490,607...108,502,337
Ensembl chr 9:108,490,602...108,502,337
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag5 BCL2-associated athanogene 5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr12:111,709,488...111,713,256
Ensembl chr12:111,709,488...111,713,257
JBrowse link
G Bag6 BCL2-associated athanogene 6 IMP (MGI:3808636|PMID:18678708) UniProt PMID:18678708 MGI:3808636 NCBI chr17:35,135,156...35,147,321
Ensembl chr17:35,135,178...35,147,322
JBrowse link
G Caml calcium modulating ligand ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:55,623,005...55,632,416
Ensembl chr13:55,623,005...55,632,411
JBrowse link
G Ccar2 cell cycle activator and apoptosis regulator 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr14:70,138,168...70,153,791
Ensembl chr14:70,138,164...70,153,811
JBrowse link
G Clec16a C-type lectin domain family 16, member A IMP (MGI:5603233|PMID:24949970) MGI PMID:24949970 MGI:5603233 NCBI chr16:10,545,309...10,744,878
Ensembl chr16:10,545,339...10,744,878
JBrowse link
G Ddrgk1 DDRGK domain containing 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:130,654,033...130,664,654
Ensembl chr 2:130,653,960...130,664,659
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr15:51,786,563...51,865,461
Ensembl chr15:51,786,558...51,865,523
JBrowse link
G Fhit fragile histidine triad gene ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr14:9,550,092...11,162,061
Ensembl chr14:9,550,092...11,162,035
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 IDA (MGI:3807767|PMID:11546783) BHF-UCL PMID:11546783 MGI:3807767 NCBI chr 8:83,649,408...83,664,789
Ensembl chr 8:83,652,677...83,664,694
JBrowse link
G Hfe homeostatic iron regulator IC (MGI:5603002|PMID:24904118) BHF-UCL PMID:24904118 MGI:5603002 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Klhl40 kelch-like 40 IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:5586592|PMID:24960163)
GO_Central
MGI
PMID:21873635, PMID:24960163 MGI:5586592, MGI:6201960 NCBI chr 9:121,777,499...121,791,200
Ensembl chr 9:121,777,607...121,783,818
JBrowse link
G Map1a microtubule-associated protein 1 A IDA (MGI:5703671|PMID:26609151) ARUK-UCL PMID:26609151 MGI:5703671 NCBI chr 2:121,289,590...121,310,832
Ensembl chr 2:121,289,600...121,310,832
JBrowse link
G Mtm1 X-linked myotubular myopathy gene 1 IMP (MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:5510937 NCBI chr  X:71,210,767...71,315,413
Ensembl chr  X:71,210,767...71,315,691
JBrowse link
G N4bp1 NEDD4 binding protein 1 IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:3829128|PMID:17592138)
GO_Central
UniProt
PMID:17592138, PMID:21873635 MGI:3829128, MGI:6201960 NCBI chr 8:86,841,136...86,885,296
Ensembl chr 8:86,808,160...86,885,258
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:15,937,835...15,946,108
Ensembl chr 7:15,936,183...15,946,074
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr  X:101,640,011...101,684,351
Ensembl chr  X:101,640,060...101,684,351
JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:150,897,133...150,909,921
Ensembl chr 4:150,897,133...150,914,437
JBrowse link
G Pbk PDZ binding kinase IMP (MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:5293269 NCBI chr14:65,805,911...65,817,822
Ensembl chr14:65,805,837...65,817,822
JBrowse link
G Rpl11 ribosomal protein L11 IMP (MGI:5897550|PMID:21804542) UniProt PMID:21804542 MGI:5897550 NCBI chr 4:136,049,354...136,053,393
Ensembl chr 4:136,028,265...136,053,428
JBrowse link
G Rybp RING1 and YY1 binding protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 6:100,228,565...100,287,358
Ensembl chr 6:100,228,565...100,287,485
JBrowse link
G Sdcbp syndecan binding protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:6,365,680...6,396,122
Ensembl chr 4:6,365,650...6,408,423
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 IMP (MGI:3818351|PMID:17981124) MGI PMID:17981124 MGI:3818351 NCBI chr15:98,038,744...98,093,569
Ensembl chr15:98,038,744...98,093,744
JBrowse link
G Shh sonic hedgehog IMP (MGI:3624046|PMID:16611981) MGI PMID:16611981 MGI:3624046 NCBI chr 5:28,456,840...28,467,101
Ensembl chr 5:28,456,815...28,467,256
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 IDA
IMP
(MGI:5310666|PMID:22285184) MGI PMID:22285184 MGI:5310666 NCBI chr 9:110,132,024...110,240,178
Ensembl chr 9:110,117,708...110,240,178
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:100,651,343...100,656,060
Ensembl chr13:100,651,579...100,656,060
Ensembl chr13:100,651,579...100,656,060
JBrowse link
G Tlk2 tousled-like kinase 2 (Arabidopsis) ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:105,167,895...105,283,959
Ensembl chr11:105,178,807...105,283,959
JBrowse link
G Trim39 tripartite motif-containing 39 IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr17:36,258,872...36,272,004
Ensembl chr17:36,258,873...36,272,247
JBrowse link
G Ttc36 tetratricopeptide repeat domain 36 IMP (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr 9:44,799,400...44,802,951
Ensembl chr 9:44,799,397...44,803,072
JBrowse link
G Ubxn1 UBX domain protein 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr19:8,871,548...8,875,666
Ensembl chr19:8,871,496...8,875,863
JBrowse link
G Uchl5 ubiquitin carboxyl-terminal esterase L5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:143,777,234...143,807,466
Ensembl chr 1:143,777,272...143,807,466
JBrowse link
G Usp7 ubiquitin specific peptidase 7 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr16:8,688,722...8,757,067
Ensembl chr16:8,689,595...8,792,308
JBrowse link
G Wac WW domain containing adaptor with coiled-coil ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr18:7,868,825...7,929,028
Ensembl chr18:7,868,832...7,929,028
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Styx serine/threonine/tyrosine interaction protein ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr14:45,351,186...45,376,884
Ensembl chr14:45,351,093...45,422,820
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anks1 ankyrin repeat and SAM domain containing 1 IDA (MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:4461099 NCBI chr17:27,909,304...28,062,779
Ensembl chr17:27,909,306...28,062,775
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IDA
ISO
(MGI:5468878|PMID:23277542) MGI PMID:23277542 GO_REF:0000096, MGI:4834177, MGI:5468878 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:152,226,535...152,281,856
Ensembl chr 2:152,226,839...152,281,852
JBrowse link
G Csnk2a2 casein kinase 2, alpha prime polypeptide ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:95,446,096...95,488,868
Ensembl chr 8:95,446,096...95,490,039
JBrowse link
G Hfe homeostatic iron regulator IC
ISO
(MGI:5603002|PMID:24904118) BHF-UCL
MGI
PMID:24904118 GO_REF:0000096, MGI:4834177, MGI:5603002 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 6:38,687,512...38,876,331
Ensembl chr 6:38,694,390...38,876,165
JBrowse link
G Pdcl3 phosducin-like 3 ISO MGI GO_REF:0000008, MGI:2154458 NCBI chr 1:38,987,814...38,997,236
Ensembl chr 1:38,985,608...38,997,238
JBrowse link
G Pml promyelocytic leukemia ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:58,217,179...58,249,796
Ensembl chr 9:58,218,076...58,249,786
JBrowse link
G Psen1 presenilin 1 IMP (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Psen2 presenilin 2 IMP (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chr 1:180,227,004...180,263,467
Ensembl chr 1:180,227,004...180,263,438
JBrowse link
G Qrich2 glutamine rich 2 IMP
ISO
(MGI:6277293|PMID:30683861) UniProt
MGI
PMID:30683861 GO_REF:0000096, MGI:4834177, MGI:6277293 NCBI chr11:116,441,323...116,466,266
Ensembl chr11:116,441,325...116,466,241
JBrowse link
G Rpl11 ribosomal protein L11 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:136,049,354...136,053,393
Ensembl chr 4:136,028,265...136,053,428
JBrowse link
G Rpl23 ribosomal protein L23 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:97,777,526...97,782,439
Ensembl chr11:97,777,527...97,782,437
JBrowse link
G Rpl5 ribosomal protein L5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 5:107,900,508...107,909,005
Ensembl chr 5:107,900,502...107,909,005
JBrowse link
G Rps7 ribosomal protein S7 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr12:28,630,847...28,635,953
Ensembl chr12:28,630,854...28,635,953
JBrowse link
G Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr10:81,044,071...81,060,271
Ensembl chr10:81,044,075...81,060,181
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling IGI (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr19:46,396,896...46,488,804
Ensembl chr19:46,396,896...46,488,804
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr  X:101,527,572...101,601,789
Ensembl chr  X:101,532,734...101,601,789
JBrowse link
G Trim39 tripartite motif-containing 39 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr17:36,258,872...36,272,004
Ensembl chr17:36,258,873...36,272,247
JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 IDA (MGI:3628833|PMID:16601693) MGI PMID:16601693 MGI:3628833 NCBI chr15:98,789,857...98,793,830
Ensembl chr15:98,789,857...98,793,837
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    metabolic process 11305
      primary metabolic process 9918
        protein metabolic process 5412
          proteolysis 1747
            negative regulation of proteolysis 360
              negative regulation of proteolysis involved in cellular protein catabolic process 68
                negative regulation of proteasomal protein catabolic process + 50
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 53
Path 2
Term Annotations click to browse term
  biological_process 23386
    biological regulation 13124
      regulation of biological process 12484
        regulation of metabolic process 6910
          regulation of macromolecule metabolic process 6431
            regulation of protein metabolic process 2833
              regulation of protein catabolic process 399
                negative regulation of protein catabolic process 127
                  negative regulation of cellular protein catabolic process 81
                    negative regulation of proteolysis involved in cellular protein catabolic process 68
                      negative regulation of proteasomal protein catabolic process + 50
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.