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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EFNA1 ephrin A1 IEA Ensembl GO_REF:0000107 NCBI chr 4:94,666,457...94,673,442
Ensembl chr 4:94,666,460...94,674,072
JBrowse link
G EPHA4 EPH receptor A4 IEA Ensembl GO_REF:0000107 NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,813...123,503,126
JBrowse link
G P14ARF p14ARF protein ISO (PMID:25217637)
(MGI:5468878|PMID:23277542)
ParkinsonsUK-UCL
MGI
PMID:23277542, PMID:25217637 MGI:5468878 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,774,496...200,798,854
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SGTA small glutamine rich tetratricopeptide repeat containing alpha IEA Ensembl GO_REF:0000107 NCBI chr 2:75,879,081...75,896,279
Ensembl chr 2:75,879,132...75,896,279
JBrowse link
G SVIP small VCP interacting protein ISO (PMID:17872946) UniProtKB PMID:17872946 NCBI chr 2:36,703,757...36,714,018 JBrowse link
G USP14 ubiquitin specific peptidase 14 IEA Ensembl GO_REF:0000107 NCBI chr 6:106,087,921...106,139,717
Ensembl chr 6:106,087,922...106,139,377
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP11 aquaporin 11 IEA Ensembl GO_REF:0000107 NCBI chr 9:12,065,550...12,076,339
Ensembl chr 9:12,065,546...12,078,401
JBrowse link
G UBXN1 UBX domain protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:9,072,549...9,075,595
Ensembl chr 2:9,072,962...9,075,595
JBrowse link
G USP25 ubiquitin specific peptidase 25 IEA Ensembl GO_REF:0000107 NCBI chr13:180,571,019...180,708,966
Ensembl chr13:180,570,969...180,714,075
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase IEA Ensembl GO_REF:0000107 NCBI chr 1:254,015,426...254,027,584
Ensembl chr 1:254,012,196...254,027,485
JBrowse link
G F8A1 coagulation factor VIII-associated 1 ISO (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:125,280,978...125,282,771 JBrowse link
G GABARAPL2 GABA type A receptor associated protein like 2 ISO (PMID:21669198) BHF-UCL PMID:21669198 NCBI chr 6:12,122,219...12,132,986
Ensembl chr 6:12,105,658...12,132,990
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO PMID:17517623
(MGI:6148636|PMID:17517623)
ARUK-UCL PMID:17517623 MGI:6148636, RGD:13514081 NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,254,002
JBrowse link
G LAMP3 lysosomal associated membrane protein 3 ISO (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chr13:121,081,717...121,117,660 JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 IEA Ensembl GO_REF:0000107 NCBI chr15:66,649,363...66,699,647
Ensembl chr15:66,649,049...66,700,433
JBrowse link
G OPHN1 oligophrenin 1 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr  X:54,056,504...54,617,045
Ensembl chr  X:53,884,012...54,616,960
JBrowse link
G PRKCG protein kinase C gamma IEA Ensembl GO_REF:0000107 NCBI chr 6:56,213,479...56,235,683
Ensembl chr 6:56,213,483...56,234,656
JBrowse link
G PSME3IP1 proteasome activator subunit 3 interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:19,098,097...19,154,288
Ensembl chr 6:19,102,180...19,154,194
JBrowse link
G PSMF1 proteasome inhibitor subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr17:34,118,324...34,164,723
Ensembl chr17:34,098,991...34,169,230
JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 IEA Ensembl GO_REF:0000107 NCBI chr12:55,406,730...55,424,120
Ensembl chr12:55,405,651...55,424,118
JBrowse link
G USP19 ubiquitin specific peptidase 19 IEA Ensembl GO_REF:0000107 NCBI chr13:31,726,668...31,738,135
Ensembl chr13:31,726,731...31,738,770
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG5 BAG cochaperone 5 IEA Ensembl GO_REF:0000107
G BAG6 BAG cochaperone 6 ISS UniProt GO_REF:0000024 NCBI chr 7:23,756,897...23,768,659
Ensembl chr 7:23,756,897...23,775,893
JBrowse link
G CAMLG calcium modulating ligand IEA Ensembl GO_REF:0000107 NCBI chr 2:136,957,626...136,967,944
Ensembl chr 2:136,957,624...136,968,381
JBrowse link
G CCAR2 cell cycle and apoptosis regulator 2 IEA Ensembl GO_REF:0000107 NCBI chr14:6,860,052...6,874,334
Ensembl chr14:6,859,663...6,874,331
JBrowse link
G CLEC16A C-type lectin domain containing 16A IEA Ensembl GO_REF:0000107 NCBI chr 3:31,938,133...32,158,343
Ensembl chr 3:31,938,135...32,158,558
JBrowse link
G DDRGK1 DDRGK domain containing 1 IEA Ensembl GO_REF:0000107 NCBI chr17:32,479,981...32,491,401
Ensembl chr17:32,479,976...32,491,400
JBrowse link
G EIF3H eukaryotic translation initiation factor 3 subunit H ISO (PMID:32269044) FlyBase PMID:32269044 NCBI chr 4:21,955,026...22,053,683
Ensembl chr 4:21,955,042...22,058,707
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr13:41,443,963...42,884,799
Ensembl chr13:41,443,965...42,228,680
JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:64,780,447...64,794,922
Ensembl chr 2:64,780,442...64,798,783
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,254,002
JBrowse link
G KLHL40 kelch like family member 40 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:26,202,607...26,211,528
Ensembl chr13:26,202,677...26,211,523
JBrowse link
G MAP1A microtubule associated protein 1A ISO (MGI:5703671|PMID:26609151) ARUK-UCL PMID:26609151 MGI:5703671 NCBI chr 1:127,916,639...127,936,952
Ensembl chr 1:127,916,644...127,936,955
JBrowse link
G MTM1 myotubularin 1 ISO (MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:5510937 NCBI chr  X:122,286,904...122,379,302
Ensembl chr  X:122,286,916...122,379,299
JBrowse link
G N4BP1 NEDD4 binding protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:36,122,189...36,177,965
Ensembl chr 6:36,122,035...36,174,536
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IEA Ensembl GO_REF:0000107 NCBI chr 6:53,443,453...53,451,707
Ensembl chr 6:53,443,480...53,452,019
JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase IEA Ensembl GO_REF:0000107 NCBI chr  X:57,521,091...57,558,467
Ensembl chr  X:57,521,097...57,558,519
JBrowse link
G PARK7 Parkinsonism associated deglycase IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,520
JBrowse link
G PBK PDZ binding kinase IEA Ensembl GO_REF:0000107 NCBI chr14:11,543,657...11,577,286
Ensembl chr14:11,543,599...11,566,702
JBrowse link
G RPL11 ribosomal protein L11 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 6:81,523,510...81,526,925
Ensembl chr 6:81,522,726...81,530,459
JBrowse link
G RYBP RING1 and YY1 binding protein IEA Ensembl GO_REF:0000107 NCBI chr13:53,724,062...53,809,698
Ensembl chr13:53,724,071...53,809,690
JBrowse link
G SDCBP syndecan binding protein ISO (PMID:25893292) UniProtKB PMID:25893292 NCBI chr 4:74,295,941...74,357,720
Ensembl chr 4:74,295,922...74,341,085
JBrowse link
G SENP1 SUMO specific peptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:78,419,849...78,476,315
Ensembl chr 5:78,423,383...78,476,195
JBrowse link
G SHH sonic hedgehog signaling molecule IEA Ensembl GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,718...2,555,484
JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 IEA Ensembl GO_REF:0000107 NCBI chr13:30,409,979...30,576,270
Ensembl chr13:30,409,982...30,601,441
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 IEA Ensembl GO_REF:0000107 NCBI chr16:47,494,841...47,499,568
Ensembl chr16:47,488,941...47,499,542
JBrowse link
G TLK2 tousled like kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr12:16,129,249...16,256,642
Ensembl chr12:16,129,244...16,255,531
JBrowse link
G TRIM39 tripartite motif containing 39 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:23,047,048...23,062,974
Ensembl chr 7:23,050,195...23,064,498
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr 9:45,829,014...45,838,978
Ensembl chr 9:45,829,191...45,838,979
JBrowse link
G UBXN1 UBX domain protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:9,072,549...9,075,595
Ensembl chr 2:9,072,962...9,075,595
JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 ISO (PMID:23770237) UniProtKB PMID:23770237 NCBI chr10:725,688...761,633
Ensembl chr10:725,489...764,006
JBrowse link
G USP7 ubiquitin specific peptidase 7 IEA Ensembl GO_REF:0000107 NCBI chr 3:33,754,357...33,810,480
Ensembl chr 3:33,775,829...33,810,466
JBrowse link
G WAC WW domain containing adaptor with coiled-coil IEA Ensembl GO_REF:0000107 NCBI chr10:39,932,562...40,024,114
Ensembl chr10:39,932,570...40,024,115
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STYX serine/threonine/tyrosine interacting protein IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:182,357,597...182,407,792
Ensembl chr 1:182,357,607...182,407,782
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:4461099 NCBI chr 7:30,812,925...30,995,369
Ensembl chr 7:30,812,920...30,995,361
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr17:34,692,960...34,748,067 JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:19,975,030...20,016,768
Ensembl chr 6:19,976,927...20,016,741
JBrowse link
G HFE homeostatic iron regulator IEA Ensembl GO_REF:0000107 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,768,741
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr18:9,940,535...10,141,815
Ensembl chr18:9,747,737...10,135,083
JBrowse link
G P14ARF p14ARF protein ISO (PMID:16173922), (PMID:18560357)
(MGI:5468878|PMID:23277542)
CAFA
MGI
PMID:16173922, PMID:18560357, PMID:23277542 MGI:5468878 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,774,496...200,798,854
JBrowse link
G PDCL3 phosducin like 3 IEA Ensembl GO_REF:0000107 NCBI chr 3:53,681,798...53,693,034
Ensembl chr 3:53,674,509...53,692,928
JBrowse link
G PML PML nuclear body scaffold IEA Ensembl GO_REF:0000107 NCBI chr 7:59,405,044...59,450,155
Ensembl chr 7:59,405,048...59,450,150
JBrowse link
G PSEN1 presenilin 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:96,478,179...96,567,884
Ensembl chr 7:96,478,181...96,569,132
JBrowse link
G PSEN2 presenilin 2 ISO (MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:4887523 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,550...14,561,858
JBrowse link
G QRICH2 glutamine rich 2 IEA Ensembl GO_REF:0000107 NCBI chr12:5,174,531...5,203,797
Ensembl chr12:5,176,536...5,200,752
JBrowse link
G RPL11 ribosomal protein L11 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 6:81,523,510...81,526,925
Ensembl chr 6:81,522,726...81,530,459
JBrowse link
G RPL23 ribosomal protein L23 IEA Ensembl GO_REF:0000107 NCBI chr12:23,279,965...23,285,538
Ensembl chr12:23,279,967...23,290,192
JBrowse link
G RPL5 ribosomal protein L5 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 4:124,359,786...124,367,612
Ensembl chr 4:124,358,592...124,367,647
JBrowse link
G RPS7 ribosomal protein S7 IEA Ensembl GO_REF:0000107 NCBI chr 3:131,258,709...131,263,285
Ensembl chr 3:131,258,713...131,342,877
JBrowse link
G SGTA small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chr 2:75,879,081...75,896,279
Ensembl chr 2:75,879,132...75,896,279
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr14:113,500,001...113,628,064
Ensembl chr14:113,500,842...113,614,517
JBrowse link
G TAF1 TATA-box binding protein associated factor 1 ISO (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chr  X:57,382,211...57,466,700 JBrowse link
G TRIM39 tripartite motif containing 39 ISO (PMID:19100260) BHF-UCL PMID:19100260 NCBI chr 7:23,047,048...23,062,974
Ensembl chr 7:23,050,195...23,064,498
JBrowse link
G WNT1 Wnt family member 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:15,010,607...15,015,007
Ensembl chr 5:15,010,985...15,014,079
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    metabolic process 10584
      primary metabolic process 9383
        protein metabolic process 5302
          proteolysis 1658
            negative regulation of proteolysis 341
              negative regulation of proteolysis involved in cellular protein catabolic process 68
                negative regulation of proteasomal protein catabolic process + 49
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 53
Path 2
Term Annotations click to browse term
  biological_process 16548
    biological regulation 12014
      regulation of biological process 11423
        regulation of metabolic process 6436
          regulation of macromolecule metabolic process 5968
            regulation of protein metabolic process 2764
              regulation of protein catabolic process 394
                negative regulation of protein catabolic process 128
                  negative regulation of cellular protein catabolic process 81
                    negative regulation of proteolysis involved in cellular protein catabolic process 68
                      negative regulation of proteasomal protein catabolic process + 49
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.