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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis involved in cellular protein catabolic process
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Accession:GO:1903051 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.
Comment:Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP).
Synonyms:exact_synonym: down regulation of peptidolysis involved in cellular protein catabolic process;   down regulation of peptidolysis involved in cellular protein catabolism;   down regulation of proteolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolic process;   downregulation of peptidolysis involved in cellular protein catabolism;   downregulation of proteolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolic process;   negative regulation of peptidolysis involved in cellular protein catabolism
 narrow_synonym: inhibition of peptidolysis involved in cellular protein catabolic process;   inhibition of peptidolysis involved in cellular protein catabolism;   inhibition of proteolysis involved in cellular protein catabolic process
 related_synonym: down regulation of peptidolysis during cellular protein catabolic process;   down regulation of peptidolysis during cellular protein catabolism;   down regulation of proteolysis during cellular protein catabolic process;   down regulation of proteolysis during cellular protein catabolism;   downregulation of peptidolysis during cellular protein catabolic process;   downregulation of peptidolysis during cellular protein catabolism;   downregulation of proteolysis during cellular protein catabolic process;   downregulation of proteolysis during cellular protein catabolism;   inhibition of peptidolysis during cellular protein catabolic process;   inhibition of peptidolysis during cellular protein catabolism;   inhibition of proteolysis during cellular protein catabolic process;   inhibition of proteolysis during cellular protein catabolism;   negative regulation of peptidolysis during cellular protein catabolic process;   negative regulation of peptidolysis during cellular protein catabolism;   negative regulation of proteolysis during cellular protein catabolic process;   negative regulation of proteolysis during cellular protein catabolism


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negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO UniProtKB:Q9BXM7 (PMID:25217637)
(MGI:5468878|PMID:23277542)
RGD PMID:23277542, PMID:25217637 MGI:5468878 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Efna1 ephrin A1 ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Epha4 Eph receptor A4 ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO
ISS
(PMID:23129660)
GO_REF:0000024
RGD
UniProt
PMID:23129660 GO_REF:0000024 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Svip small VCP interacting protein IC
IBA
ISO
PMID:17000876
PMID:21873635
(PMID:17872946)
RGD PMID:17872946, PMID:17000876, PMID:21873635 RGD:10047192, RGD:13792537 NCBI chr 1:107,368,117...107,373,807
Ensembl chr 1:107,368,117...107,373,807
JBrowse link
G Usp14 ubiquitin specific peptidase 14 ISO (PMID:19135427) RGD PMID:19135427 NCBI chr18:1,178,785...1,216,573
Ensembl chr18:1,178,787...1,216,409
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 ISS
ISO
GO_REF:0000024
(MGI:3813160|PMID:18606867)
UniProt
RGD
PMID:18606867 GO_REF:0000024, MGI:3813160 NCBI chr 1:162,703,394...162,713,560
Ensembl chr 1:162,703,442...162,713,610
JBrowse link
G Ubxn1 UBX domain protein 1 ISO (PMID:21135095) RGD PMID:21135095 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO (PMID:22590560) RGD PMID:22590560 NCBI chr11:15,436,080...15,558,646
Ensembl chr11:15,436,269...15,558,646
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO (PMID:8175643) RGD PMID:8175643 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G F8a1 coagulation factor VIII-associated 1 ISO
ISS
(PMID:27815841)
GO_REF:0000024
RGD
UniProt
PMID:27815841 GO_REF:0000024 NCBI chr 1:147,021,436...147,022,950
Ensembl chr 1:147,021,436...147,022,950
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 ISO (PMID:21669198) RGD PMID:21669198 NCBI chr19:44,164,935...44,175,771
Ensembl chr19:44,164,935...44,175,770
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 IMP
ISO
PMID:17517623
(MGI:6148636|PMID:17517623)
RGD PMID:17517623, PMID:17517623 MGI:6148636, RGD:13514081 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 ISO (PMID:25681212) RGD PMID:25681212 NCBI chr11:84,930,965...85,000,694
Ensembl chr11:84,972,132...85,000,681
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO
ISS
(PMID:29295817)
GO_REF:0000024
RGD
UniProt
PMID:29295817 GO_REF:0000024 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Ophn1 oligophrenin 1 IBA
ISO
PMID:21873635
(MGI:5303043|PMID:21874017)
RGD PMID:21874017, PMID:21873635 MGI:5303043, RGD:13792537 NCBI chr  X:68,185,865...68,579,518
Ensembl chr  X:68,189,161...68,563,137
JBrowse link
G Prkcg protein kinase C, gamma ISS
ISO
GO_REF:0000024
(MGI:5467682|PMID:23185022)
UniProt
RGD
PMID:23185022 GO_REF:0000024, MGI:5467682 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Psme3ip1 proteasome activator subunit 3 interacting protein 1 ISO (PMID:29934401) RGD PMID:29934401 NCBI chr19:10,827,057...10,856,747
Ensembl chr19:10,827,371...10,856,745
JBrowse link
G Psmf1 proteasome inhibitor subunit 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:10764772)
Ensembl
UniProt
RGD
PMID:10764772 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:147,238,111...147,263,275
Ensembl chr 3:147,238,114...147,263,275
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 ISO MGI:2176228|MGI:5758867 (MGI:5643882|PMID:25683716) RGD PMID:25683716 MGI:5643882 NCBI chr10:53,595,854...53,608,437
Ensembl chr10:53,595,854...53,608,435
JBrowse link
G Usp19 ubiquitin specific peptidase 19 IEA
ISO
GO_REF:0000107
(MGI:5614537|PMID:25088257)
Ensembl
RGD
PMID:25088257 GO_REF:0000107, MGI:5614537 NCBI chr 8:117,280,690...117,291,729
Ensembl chr 8:117,280,705...117,291,351
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag5 BAG cochaperone 5 ISO (PMID:24475098) RGD PMID:24475098 NCBI chr 6:136,180,640...136,185,651
Ensembl chr 6:136,182,006...136,185,651
JBrowse link
G Bag6 BAG cochaperone 6 ISS
ISO
GO_REF:0000024
(MGI:3808636|PMID:18678708)
UniProt
RGD
PMID:18678708 GO_REF:0000024, MGI:3808636 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Camlg calcium modulating ligand ISO UniProtKB:Q9H9V4 (PMID:20553626) RGD PMID:20553626 NCBI chr17:9,523,792...9,534,683
Ensembl chr17:9,523,795...9,534,653
JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 ISO (PMID:23398316) RGD PMID:23398316 NCBI chr15:51,818,887...51,834,443
Ensembl chr15:51,818,897...51,834,030
JBrowse link
G Clec16a C-type lectin domain containing 16A ISO MGI:5648633 (MGI:5603233|PMID:24949970) RGD PMID:24949970 MGI:5603233 NCBI chr10:5,002,196...5,196,914
Ensembl chr10:5,009,826...5,196,892
JBrowse link
G Ddrgk1 DDRGK domain containing 1 ISO (PMID:28263186) RGD PMID:28263186 NCBI chr 3:123,195,580...123,206,828
Ensembl chr 3:123,195,580...123,206,828
JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H ISO (PMID:32269044) RGD PMID:32269044 NCBI chr 6:10,151,732...10,236,677 JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO
IBA
ISS
(PMID:15313915)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:15313915, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 ISO (MGI:3807767|PMID:11546783) RGD PMID:11546783 MGI:3807767 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISS
ISO
GO_REF:0000024
(PMID:16280321), (PMID:24613385)
UniProt
RGD
PMID:16280321, PMID:24613385 GO_REF:0000024 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Klhl40 kelch-like family member 40 IBA
ISO
PMID:21873635
(MGI:5586592|PMID:24960163)
RGD PMID:24960163, PMID:21873635 MGI:5586592, RGD:13792537 NCBI chr 8:130,416,265...130,421,871
Ensembl chr 8:130,416,355...130,421,871
JBrowse link
G Map1a microtubule-associated protein 1A ISO (MGI:5703671|PMID:26609151) RGD PMID:26609151 MGI:5703671 NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186
JBrowse link
G Mtm1 myotubularin 1 ISO MGI:2450997 (MGI:5510937|PMID:23695157) RGD PMID:23695157 MGI:5510937 NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
JBrowse link
G N4bp1 Nedd4 binding protein 1 IBA
ISO
PMID:21873635
(MGI:3829128|PMID:17592138)
RGD PMID:17592138, PMID:21873635 MGI:3829128, RGD:13792537 NCBI chr19:21,218,123...21,268,539
Ensembl chr19:21,218,465...21,266,964
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:22522597) RGD PMID:22522597 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IEA
ISO
GO_REF:0000107
(PMID:26678539)
Ensembl
RGD
PMID:26678539 GO_REF:0000107 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
IEA
(PMID:17015834)
GO_REF:0000107
RGD
Ensembl
PMID:17015834 GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pbk PDZ binding kinase ISO MGI:5293435 (MGI:5293269|PMID:21715333) RGD PMID:21715333 MGI:5293269 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Rpl11 ribosomal protein L11 ISS
ISO
GO_REF:0000024
(MGI:5897550|PMID:21804542)
UniProt
RGD
PMID:21804542 GO_REF:0000024, MGI:5897550 NCBI chr 5:154,390,809...154,394,412
Ensembl chr 5:154,388,140...154,394,328
JBrowse link
G Rybp RING1 and YY1 binding protein ISO (PMID:27060496) RGD PMID:27060496 NCBI chr 4:132,689,623...132,740,823
Ensembl chr 4:132,689,531...132,740,938
JBrowse link
G Sdcbp syndecan binding protein ISO
ISS
(PMID:25893292)
GO_REF:0000024
RGD
UniProt
PMID:25893292 GO_REF:0000024 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
G Senp1 SUMO specific peptidase 1 ISO MGI:3818522 (MGI:3818351|PMID:17981124) RGD PMID:17981124 MGI:3818351 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Shh sonic hedgehog signaling molecule IEA
ISO
GO_REF:0000107
(MGI:3624046|PMID:16611981)
Ensembl
RGD
PMID:16611981 GO_REF:0000107, MGI:3624046 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 ISO (MGI:5310666|PMID:22285184) RGD PMID:22285184 MGI:5310666 NCBI chr 8:118,206,678...118,326,264
Ensembl chr 8:118,206,698...118,325,537
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 ISO (PMID:11278372) RGD PMID:11278372 NCBI chr 2:30,664,407...30,668,414
Ensembl chr 2:30,664,639...30,668,414
JBrowse link
G Tlk2 tousled-like kinase 2 ISO (PMID:20016786) RGD PMID:20016786 NCBI chr10:93,410,181...93,507,277
Ensembl chr10:93,415,399...93,507,277
JBrowse link
G Trim39 tripartite motif-containing 39 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:23213251)
UniProt
RGD
PMID:23213251, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:2,500,691...2,514,546
Ensembl chr20:2,500,689...2,514,546
JBrowse link
G Ttc36 tetratricopeptide repeat domain 36 ISO MGI:5588394 (MGI:6362140|PMID:31537781) RGD PMID:31537781 MGI:6362140 NCBI chr 8:49,106,374...49,109,981
Ensembl chr 8:49,106,374...49,109,981
JBrowse link
G Ubxn1 UBX domain protein 1 ISO
ISS
(PMID:20351172)
GO_REF:0000024
RGD
UniProt
PMID:20351172 GO_REF:0000024 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945
JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 ISO (PMID:23770237) RGD PMID:23770237 NCBI chr13:60,568,102...60,603,812
Ensembl chr13:60,545,635...60,603,811
JBrowse link
G Usp7 ubiquitin specific peptidase 7 IEA
ISO
GO_REF:0000107
(PMID:26678539)
Ensembl
RGD
PMID:26678539 GO_REF:0000107 NCBI chr10:6,930,462...7,019,910
Ensembl chr10:6,975,244...7,018,930
JBrowse link
G Wac WW domain containing adaptor with coiled-coil ISO (PMID:22354037) RGD PMID:22354037 NCBI chr17:60,887,606...60,946,630
Ensembl chr17:60,888,017...60,946,426
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Styx serine/threonine/tyrosine interacting protein ISO
IBA
(PMID:28007894)
PMID:21873635
RGD PMID:28007894, PMID:21873635 RGD:13792537 NCBI chr15:19,690,079...19,720,683
Ensembl chr15:19,690,194...19,717,774
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anks1a ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:4461099|PMID:20100865) RGD PMID:20100865 MGI:4461099 NCBI chr20:7,484,550...7,636,498
Ensembl chr20:7,484,550...7,636,497
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:16173922), (PMID:18560357)
(MGI:5468878|PMID:23277542)
RGD PMID:16173922, PMID:18560357, PMID:23277542 MGI:5468878 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO UniProtKB:P19784|UniProtKB:P25686|UniProtKB:P67870 (PMID:28031292) RGD PMID:28031292 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO UniProtKB:P25686|UniProtKB:P67870|UniProtKB:P68400 (PMID:28031292) RGD PMID:28031292 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
JBrowse link
G Hfe homeostatic iron regulator ISO (PMID:24904118) RGD PMID:24904118 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO (PMID:21628596) RGD PMID:21628596 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Pdcl3 phosducin-like 3 ISO (PMID:23792958) RGD PMID:23792958 NCBI chr 9:45,672,257...45,680,728
Ensembl chr 9:45,672,157...45,680,799
JBrowse link
G Pml PML nuclear body scaffold ISO (PMID:15195100) RGD PMID:15195100 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Psen1 presenilin 1 ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Qrich2 glutamine rich 2 ISO (PMID:30683861)
(MGI:6277293|PMID:30683861)
RGD PMID:30683861 MGI:6277293 NCBI chr10:105,397,470...105,422,811
Ensembl chr10:105,399,814...105,412,627
JBrowse link
G Rpl11 ribosomal protein L11 ISO (PMID:18560357) RGD PMID:18560357 NCBI chr 5:154,390,809...154,394,412
Ensembl chr 5:154,388,140...154,394,328
JBrowse link
G Rpl23 ribosomal protein L23 ISO (PMID:15314173) RGD PMID:15314173 NCBI chr10:85,721,398...85,725,359
Ensembl chr10:85,721,394...85,725,429
JBrowse link
G Rpl5 ribosomal protein L5 ISO (PMID:18560357) RGD PMID:18560357 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link
G Rps7 ribosomal protein S7 ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat containing alpha ISO
ISS
(PMID:23129660)
GO_REF:0000024
RGD
UniProt
PMID:23129660 GO_REF:0000024 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:1343085 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 ISO (PMID:17237821) RGD PMID:17237821 NCBI chr  X:71,412,291...71,486,456
Ensembl chr  X:71,412,289...71,485,085
JBrowse link
G Trim39 tripartite motif-containing 39 ISO (PMID:19100260) RGD PMID:19100260 NCBI chr20:2,500,691...2,514,546
Ensembl chr20:2,500,689...2,514,546
JBrowse link
G Wnt1 Wnt family member 1 ISO (MGI:3628833|PMID:16601693) RGD PMID:16601693 MGI:3628833 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      primary metabolic process 10900
        protein metabolic process 6221
          proteolysis 1893
            negative regulation of proteolysis 403
              negative regulation of proteolysis involved in cellular protein catabolic process 68
                negative regulation of proteasomal protein catabolic process + 49
                negative regulation of proteolysis associated with antigen processing and presentation 0
                negative regulation of ubiquitin-dependent protein catabolic process + 53
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of metabolic process 6993
          regulation of macromolecule metabolic process 6498
            regulation of protein metabolic process 2956
              regulation of protein catabolic process 398
                negative regulation of protein catabolic process 127
                  negative regulation of cellular protein catabolic process 81
                    negative regulation of proteolysis involved in cellular protein catabolic process 68
                      negative regulation of proteasomal protein catabolic process + 49
                      negative regulation of proteolysis associated with antigen processing and presentation 0
                      negative regulation of ubiquitin-dependent protein catabolic process + 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.