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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of tumor necrosis factor-mediated signaling pathway
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Accession:GO:1903265 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.
Synonyms:exact_synonym: positive regulation of tumor necrosis factor-mediated signalling pathway;   up regulation of tumor necrosis factor-mediated signaling pathway;   up regulation of tumor necrosis factor-mediated signalling pathway;   upregulation of tumor necrosis factor-mediated signaling pathway;   upregulation of tumor necrosis factor-mediated signalling pathway
 narrow_synonym: activation of TNF-alpha-mediated signaling pathway;   activation of tumor necrosis factor alpha-mediated signaling pathway;   activation of tumor necrosis factor-mediated signaling pathway;   activation of tumor necrosis factor-mediated signalling pathway;   positive regulation of TNF-alpha-mediated signaling pathway;   positive regulation of tumor necrosis factor alpha-mediated signaling pathway;   up regulation of TNF-alpha-mediated signaling pathway;   up regulation of tumor necrosis factor alpha-mediated signaling pathway;   upregulation of TNF-alpha-mediated signaling pathway;   upregulation of tumor necrosis factor alpha-mediated signaling pathway
 related_synonym: activation of adipocytokine signaling pathway;   positive regulation of adipocytokine signaling pathway;   up regulation of adipocytokine signaling pathway;   upregulation of adipocytokine signaling pathway


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positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:24813629)
GO_REF:0000107
RGD
Ensembl
PMID:24813629 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Casp1 caspase 1 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Cpne1 copine 1 ISO
IBA
(PMID:14674885)
PMID:21873635
RGD PMID:14674885, PMID:21873635 RGD:13792537 NCBI chr 3:151,617,733...151,625,448
NCBI chr 3:152,150,143...152,192,936
Ensembl chr 3:151,616,037...151,625,644
Ensembl chr 3:151,616,037...151,625,644
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO
ISS
(PMID:23453807)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:23453807 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rbm12 RNA binding motif protein 12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:MGI:6271183|PMID:30439713) RGD PMID:30439713 MGI:MGI:6271183 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (MGI:MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:MGI:5616328 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Trim32 tripartite motif-containing 32 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:26707646) RGD PMID:26707646 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    cellular process 18788
      signal transduction 7016
        positive regulation of signal transduction 1683
          positive regulation of cytokine-mediated signaling pathway 47
            positive regulation of tumor necrosis factor-mediated signaling pathway 12
Path 2
Term Annotations click to browse term
  biological_process 20015
    biological regulation 13760
      regulation of biological process 13073
        regulation of cellular process 12563
          signal transduction 7016
            cell surface receptor signaling pathway 2783
              cytokine-mediated signaling pathway 404
                regulation of cytokine-mediated signaling pathway 113
                  positive regulation of cytokine-mediated signaling pathway 47
                    positive regulation of tumor necrosis factor-mediated signaling pathway 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.