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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway


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positive regulation of regulated secretory pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab15 RAB15, member RAS oncogene family ISO UniProtKB:P51159 (PMID:22899725) RGD PMID:22899725 NCBI chr 6:99,845,952...99,870,320
Ensembl chr 6:99,845,954...99,870,024
JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO UniProtKB:P59190 (PMID:22899725) RGD PMID:22899725 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Rab3a RAB3A, member RAS oncogene family ISO (PMID:22899725) RGD PMID:22899725 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Rab3d RAB3D, member RAS oncogene family ISO (PMID:22899725) RGD PMID:22899725 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294
JBrowse link
G Unc13d unc-13 homolog D IEA
ISO
GO_REF:0000107
UniProtKB:P51159 (PMID:22899725)
Ensembl
RGD
PMID:22899725 GO_REF:0000107 NCBI chr10:104,613,907...104,628,664
Ensembl chr10:104,613,928...104,628,676
JBrowse link
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1b calcium voltage-gated channel subunit alpha1 B IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:1,740,026...1,924,959
Ensembl chr 3:1,740,024...1,924,827
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526
JBrowse link
G Cdk5 cyclin-dependent kinase 5 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cnr1 cannabinoid receptor 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:4834982|PMID:20586096)
Ensembl
UniProt
RGD
PMID:20586096 GO_REF:0000024, GO_REF:0000107, MGI:4834982 NCBI chr 8:116,336,512...116,342,147
Ensembl chr 8:116,336,512...116,342,146
JBrowse link
G Zp3 zona pellucida glycoprotein 3 ISS
ISO
GO_REF:0000024
(PMID:19004505), (PMID:19246320)
UniProt
RGD
PMID:19004505, PMID:19246320 GO_REF:0000024 NCBI chr12:23,735,225...23,752,734
Ensembl chr12:23,735,223...23,742,190
JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 IDA RGD PMID:10657240 RGD:9684853 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:17172292, PMID:21873635 RGD:2316206, RGD:13792537 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Cadps calcium dependent secretion activator IMP RGD PMID:9289490 RGD:1299539 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 9:82,120,059...82,121,527
Ensembl chr 9:82,120,059...82,121,527
JBrowse link
G Cltrn collectrin, amino acid transport regulator ISO
IBA
(PMID:16330323)
PMID:21873635
RGD PMID:16330323, PMID:21873635 RGD:13792537 NCBI chr  X:32,118,082...32,153,687
Ensembl chr  X:32,118,054...32,153,794
JBrowse link
G Doc2b double C2 domain beta IDA
IEA
PMID:18596155
GO_REF:0000002
InterPro PMID:18596155 GO_REF:0000002, RGD:8554556 NCBI chr10:63,921,255...63,952,944
Ensembl chr10:63,928,064...63,952,726
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 IDA PMID:17301173
PMID:20484665
PMID:18167541
UniProt PMID:17301173, PMID:20484665, PMID:18167541 RGD:10047384, RGD:10047179, RGD:10047360 NCBI chr 3:163,850,785...163,935,610
Ensembl chr 3:163,850,785...163,935,617
JBrowse link
G Scamp5 secretory carrier membrane protein 5 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19234194)
Ensembl
UniProt
RGD
PMID:19234194 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:62,221,820...62,266,269
Ensembl chr 8:62,220,892...62,248,017
JBrowse link
G Stx1a syntaxin 1A IDA PMID:17301173
PMID:20484665
PMID:18167541
UniProt PMID:17301173, PMID:20484665, PMID:18167541 RGD:10047384, RGD:10047179, RGD:10047360 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO (MGI:3709145|PMID:15123626) RGD PMID:15123626 MGI:3709145 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Syt1 synaptotagmin 1 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Syt10 synaptotagmin 10 ISS
ISO
GO_REF:0000024
(MGI:5751674|PMID:21496647)
UniProt
RGD
PMID:21496647 GO_REF:0000024, MGI:5751674 NCBI chr 7:130,769,039...130,827,030
Ensembl chr 7:130,768,841...130,827,152
JBrowse link
G Syt7 synaptotagmin 7 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:226,435,816...226,498,008
Ensembl chr 1:226,435,979...226,493,377
JBrowse link
G Syt9 synaptotagmin 9 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:171,592,703...171,769,780
Ensembl chr 1:171,592,797...171,769,780
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 ISS
ISO
GO_REF:0000024
(MGI:2179533|PMID:11242035)
UniProt
RGD
PMID:11242035 GO_REF:0000024, MGI:2179533 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 ISO (MGI:3795609|PMID:18468511) RGD PMID:18468511 MGI:3795609 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:11714832) RGD PMID:11714832 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Stx4 syntaxin 4 IEA
ISO
GO_REF:0000107
(PMID:16677249)
Ensembl
RGD
PMID:16677249 GO_REF:0000107 NCBI chr 1:199,287,384...199,295,606
Ensembl chr 1:199,287,710...199,294,979
JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pla2g3 phospholipase A2, group III ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
RGD PMID:23624557 MGI:5492190 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Snx4 sorting nexin 4 ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:70,693,381...70,753,620
Ensembl chr11:70,693,366...70,753,632
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:18,996,566...19,033,714
Ensembl chr12:18,996,591...19,030,381
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 IEA
ISO
GO_REF:0000107
(PMID:18253931)
Ensembl
RGD
PMID:18253931 GO_REF:0000107 NCBI chr 4:100,250,301...100,252,756
Ensembl chr 4:100,250,301...100,252,755
JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor IEA
ISO
GO_REF:0000107
(MGI:3776334|PMID:11454903)
Ensembl
RGD
PMID:11454903 GO_REF:0000107, MGI:3776334 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adora3 adenosine A3 receptor ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISS
ISO
GO_REF:0000024
(MGI:5294498|PMID:21746961)
UniProt
RGD
PMID:21746961 GO_REF:0000024, MGI:5294498 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Gab2 GRB2-associated binding protein 2 ISS
ISO
GO_REF:0000024
(MGI:2137187|PMID:11449275)
UniProt
RGD
PMID:11449275 GO_REF:0000024, MGI:2137187 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Il13 interleukin 13 ISO MGI:1931804|MGI:96556 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 IBA
ISO
PMID:21873635
MGI:1857195|MGI:96541 (MGI:3589858|PMID:15944273)
RGD PMID:15944273, PMID:21873635 MGI:3589858, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor ISO MGI:1861951 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:227,957,363...227,965,312
Ensembl chr 1:227,957,302...227,965,386
JBrowse link
G Nppc natriuretic peptide C IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Sphk2 sphingosine kinase 2 ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:2,180,101...2,191,863
Ensembl chr12:2,180,150...2,191,175
JBrowse link
G Syk spleen associated tyrosine kinase IMP
ISO
IBA
IEA
MGI:2384078 (MGI:85068|PMID:9000133)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9000133, PMID:16861349, PMID:21873635 GO_REF:0000107, MGI:85068, RGD:2299903, RGD:13792537 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:41,805,252...41,860,076 JBrowse link
G Cd160 CD160 molecule ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 ISO (PMID:23632890) RGD PMID:23632890 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule ISO
IBA
UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407)
PMID:21873635
RGD PMID:21193407, PMID:21873635 RGD:13792537 NCBI chr 1:82,964,683...82,987,306
Ensembl chr 1:82,964,683...82,987,253
JBrowse link
G Itgam integrin subunit alpha M ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G LOC100909700 CD177 antigen-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:81,609,177...81,627,763
Ensembl chr 1:81,609,433...81,627,710
JBrowse link
G LOC100910565 CD177 antigen-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:81,548,679...81,551,288
Ensembl chr 1:81,548,892...81,550,598
JBrowse link
G LOC102553892 CD177 antigen-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:82,947,303...82,952,884
Ensembl chr 1:82,948,488...82,952,936
JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:2829894 RGD:10041060 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G RGD1564380 similar to BC049730 protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:82,830,153...82,902,864
Ensembl chr 1:82,831,952...82,918,444
JBrowse link
G RGD1565655 similar to BC049730 protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:81,592,004...81,597,637
Ensembl chr 1:81,593,800...81,596,819
JBrowse link
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Dnm1l dynamin 1-like IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Nlgn1 neuroligin 1 IMP
ISO
PMID:19628693
(MGI:4355770|PMID:19628693)
RGD PMID:19628693, PMID:19628693 MGI:4355770, RGD:8554760 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326
JBrowse link
G Slc4a8 solute carrier family 4 member 8 IEA
ISO
GO_REF:0000107
(MGI:5013899|PMID:21593314)
Ensembl
RGD
PMID:21593314 GO_REF:0000107, MGI:5013899 NCBI chr 7:142,397,352...142,467,398
Ensembl chr 7:142,397,371...142,464,158
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    positive regulation of biological process 6648
      positive regulation of cellular process 6145
        positive regulation of secretion by cell 368
          positive regulation of exocytosis 110
            positive regulation of regulated secretory pathway 72
              positive regulation of calcium ion-dependent exocytosis + 20
              positive regulation of leukocyte degranulation + 39
              positive regulation of synaptic vesicle exocytosis + 11
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          secretion 1152
            secretion by cell 955
              exocytosis 426
                regulated exocytosis 292
                  regulation of regulated secretory pathway 199
                    positive regulation of regulated secretory pathway 72
                      positive regulation of calcium ion-dependent exocytosis + 20
                      positive regulation of leukocyte degranulation + 39
                      positive regulation of synaptic vesicle exocytosis + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.