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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway


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positive regulation of regulated secretory pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RAB15 RAB15, member RAS oncogene family JBrowse link 7 89,015,041 89,039,482 RGD:14298760
G RAB27A RAB27A, member RAS oncogene family JBrowse link 1 116,532,816 116,606,477 RGD:14298760
G RAB3A RAB3A, member RAS oncogene family JBrowse link 2 59,603,090 59,609,773 RGD:14298760
G RAB3D RAB3D, member RAS oncogene family JBrowse link 2 70,023,470 70,035,679 RGD:14298760
G UNC13D unc-13 homolog D JBrowse link 12 5,573,428 5,598,914 RGD:14298760
calcium-dependent activation of synaptic vesicle fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PRRT2 proline rich transmembrane protein 2 JBrowse link 3 18,048,614 18,052,481 RGD:14298760
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
G SYT7 synaptotagmin 7 JBrowse link 2 9,947,962 10,012,713 RGD:14298760
G SYT9 synaptotagmin 9 JBrowse link 9 2,191,757 2,395,157 RGD:14298760
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1D calcium voltage-gated channel subunit alpha1 D JBrowse link 13 35,568,534 35,911,483 RGD:14298760
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 10 44,321,954 44,887,410 RGD:14298760
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 15 402,801 455,691 RGD:14298760
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HYAL3 hyaluronidase 3 JBrowse link 13 32,790,843 32,796,995 RGD:14298760
G ZP3 zona pellucida glycoprotein 3 JBrowse link 3 9,934,760 9,944,924 RGD:14298760
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1B calcium voltage-gated channel subunit alpha1 B RGD:14298760
G CACNA1F calcium voltage-gated channel subunit alpha1 F JBrowse link X 43,250,449 43,284,458 RGD:14298760
G CACNA1G calcium voltage-gated channel subunit alpha1 G JBrowse link 12 26,838,633 26,912,344 RGD:14298760
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 5 8,593,014 8,702,734 RGD:14298760
G CDK5 cyclin dependent kinase 5 JBrowse link 18 6,166,914 6,171,157 RGD:14298760
G CDK5R2 cyclin dependent kinase 5 regulatory subunit 2 JBrowse link 15 120,985,069 120,990,864 RGD:14298760
G DOC2B double C2 domain beta JBrowse link 12 47,529,383 47,558,236 RGD:14298760
G KCNB1 potassium voltage-gated channel subfamily B member 1 JBrowse link 17 51,032,163 51,152,566 RGD:14298760
G STXBP1 syntaxin binding protein 1 JBrowse link 1 268,116,124 268,205,805 RGD:14298760
G SYT10 synaptotagmin 10 JBrowse link 5 40,869,418 40,940,851 RGD:14298760
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT1 synaptotagmin 1 JBrowse link 5 101,871,313 102,394,310 RGD:14298760
positive regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SYT4 synaptotagmin 4 JBrowse link 6 127,382,248 127,392,258 RGD:14298760
positive regulation of eosinophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2RL1 F2R like trypsin receptor 1 JBrowse link 2 85,732,082 85,747,552 RGD:14298760
G STX4 syntaxin 4 JBrowse link 3 17,422,266 17,431,377 RGD:14298760
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SNX4 sorting nexin 4 JBrowse link 13 134,824,028 134,903,765 RGD:14298760
G VAMP7 vesicle associated membrane protein 7 JBrowse link X 125,863,266 125,917,232 RGD:14298760
G VAMP8 vesicle associated membrane protein 8 JBrowse link 3 59,187,900 59,193,165 RGD:14298760
positive regulation of mast cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADORA2B adenosine A2b receptor JBrowse link 12 59,431,834 59,449,701 RGD:14298760
G FGR FGR proto-oncogene, Src family tyrosine kinase JBrowse link 6 84,809,534 84,830,401 RGD:14298760
G IL13 interleukin 13 JBrowse link 2 134,972,099 134,976,672 RGD:14298760
G SPHK2 sphingosine kinase 2 JBrowse link 6 53,982,911 53,986,779 RGD:14298760
G SYK spleen associated tyrosine kinase JBrowse link 14 2,103,706 2,160,886 RGD:14298760
positive regulation of natural killer cell degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LAMP1 lysosomal associated membrane protein 1 JBrowse link 11 78,600,818 78,617,587 RGD:14298760
positive regulation of neutrophil degranulation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ITGAD integrin subunit alpha D JBrowse link 3 17,136,161 17,169,776 RGD:14298760
G ITGAM integrin subunit alpha M JBrowse link 3 17,216,719 17,272,134 RGD:14298760
G ITGAX integrin subunit alpha X JBrowse link 3 17,178,725 17,201,388 RGD:14298760
G ITGB2 integrin subunit beta 2 JBrowse link 13 207,514,281 207,544,108 RGD:14298760
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NLGN1 neuroligin 1 JBrowse link 13 111,851,007 112,727,202 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15257
    cellular process 13567
      positive regulation of cellular process 3924
        positive regulation of secretion by cell 247
          positive regulation of exocytosis 63
            positive regulation of regulated secretory pathway 41
              positive regulation of calcium ion-dependent exocytosis + 14
              positive regulation of leukocyte degranulation + 15
              positive regulation of synaptic vesicle exocytosis + 8
Path 2
Term Annotations click to browse term
  biological_process 15257
    localization 4701
      establishment of localization 3574
        transport 3467
          secretion 759
            secretion by cell 671
              exocytosis 249
                regulated exocytosis 165
                  regulation of regulated secretory pathway 115
                    positive regulation of regulated secretory pathway 41
                      positive regulation of calcium ion-dependent exocytosis + 14
                      positive regulation of leukocyte degranulation + 15
                      positive regulation of synaptic vesicle exocytosis + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.