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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of reactive oxygen species biosynthetic process
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Accession:GO:1903427 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
Synonyms:exact_synonym: down regulation of reactive oxygen species anabolism;   down regulation of reactive oxygen species biosynthesis;   down regulation of reactive oxygen species biosynthetic process;   down regulation of reactive oxygen species formation;   down regulation of reactive oxygen species synthesis;   downregulation of reactive oxygen species anabolism;   downregulation of reactive oxygen species biosynthesis;   downregulation of reactive oxygen species biosynthetic process;   downregulation of reactive oxygen species formation;   downregulation of reactive oxygen species synthesis;   negative regulation of reactive oxygen species anabolism;   negative regulation of reactive oxygen species biosynthesis;   negative regulation of reactive oxygen species formation;   negative regulation of reactive oxygen species synthesis;   prevention of ROS generation
 narrow_synonym: inhibition of reactive oxygen species anabolism;   inhibition of reactive oxygen species biosynthesis;   inhibition of reactive oxygen species biosynthetic process;   inhibition of reactive oxygen species formation;   inhibition of reactive oxygen species synthesis
 related_synonym: down regulation of ROS formation;   down regulation of ROS generation;   down regulation of reactive oxygen species generation;   downregulation of ROS formation;   downregulation of ROS generation;   downregulation of reactive oxygen species generation;   inhibition of ROS formation;   inhibition of ROS generation;   inhibition of reactive oxygen species generation;   negative regulation of ROS formation;   negative regulation of ROS generation;   negative regulation of reactive oxygen species generation


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negative regulation of reactive oxygen species biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 ISO
ISS
(MGI:MGI:3836690|PMID:18723473), (MGI:MGI:5464985|PMID:22521832), (MGI:MGI:5790173|PMID:25583114)
GO_REF:0000024
RGD
UniProt
PMID:18723473, PMID:22521832, PMID:25583114 GO_REF:0000024, MGI:MGI:3836690, MGI:MGI:5464985, MGI:MGI:5790173 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 ISO
ISS
(MGI:MGI:3836690|PMID:18723473)
GO_REF:0000024
RGD
UniProt
PMID:18723473 GO_REF:0000024, MGI:MGI:3836690 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IMP RGD PMID:22209705 RGD:13800744 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IMP RGD PMID:18292530 RGD:11341712 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Coa8 cytochrome c oxidase assembly factor 8 ISO
ISS
(PMID:25175347)
GO_REF:0000024
RGD
UniProt
PMID:25175347 GO_REF:0000024 NCBI chr 6:136,185,772...136,210,936
NCBI chr 6:136,279,476...136,304,317
Ensembl chr 6:136,185,487...136,210,940
Ensembl chr 6:136,185,487...136,210,940
JBrowse link
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 IMP RGD PMID:23041468 RGD:10401126 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Hbp1 HMG-box transcription factor 1 ISO (MGI:MGI:5754467|PMID:24675724) RGD PMID:24675724 MGI:MGI:5754467 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IMP RGD PMID:22547655 RGD:10402548 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ins2 insulin 2 ISO ComplexPortal:CPX-1134 (PMID:19188609) RGD PMID:19188609 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28483668 RGD:12910717 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Park7 Parkinsonism associated deglycase ISO
ISS
(MGI:MGI:5908331|PMID:22611253)
GO_REF:0000024
RGD
UniProt
PMID:22611253 GO_REF:0000024, MGI:MGI:5908331 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:24096089 RGD:10413842 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rhoa ras homolog family member A ISO (MGI:MGI:5640904|PMID:25398325) RGD PMID:25398325 MGI:MGI:5640904 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:23422569 RGD:9585767 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc30a10 solute carrier family 30, member 10 ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
negative regulation of hydrogen peroxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter IMP RGD PMID:26482480 RGD:12910938 NCBI chr10:59,749,250...59,772,475
Ensembl chr10:59,749,256...59,764,868
JBrowse link
G Cycs cytochrome c, somatic IMP RGD PMID:21410437 RGD:7349317 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase IMP PMID:27525436 ARUK-UCL PMID:27525436 RGD:13601987 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like ISO (PMID:22306510) RGD PMID:22306510 NCBI chr10:3,321,488...3,359,219
Ensembl chr10:3,321,476...3,357,470
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:23590160 RGD:8694322 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
negative regulation of nitric oxide biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant ISO
IEA
MGI:MGI:2180086 (MGI:MGI:1930064|PMID:11168643)
GO_REF:0000107
RGD
Ensembl
PMID:11168643 GO_REF:0000107, MGI:MGI:1930064 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:11591728), (PMID:19278978) RGD PMID:11591728, PMID:19278978 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Cav1 caveolin 1 ISO
IEA
MGI:MGI:2180364 (MGI:MGI:2450774|PMID:12388077)
GO_REF:0000107
RGD
Ensembl
PMID:12388077 GO_REF:0000107, MGI:MGI:2450774 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cd34 CD34 molecule ISO
ISS
(PMID:17505307)
GO_REF:0000024
RGD
UniProt
PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Dynll1 dynein light chain LC8-type 1 IDA PMID:8864115 MGI PMID:8864115 RGD:633683 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Epor erythropoietin receptor IMP RGD PMID:10489101 RGD:11041656 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:9519713 RGD:2303775 NCBI chr 4:78,377,228...78,386,683
Ensembl chr 4:78,378,144...78,385,577
JBrowse link
G Gla galactosidase, alpha ISO (MGI:MGI:3624267|PMID:15668341) RGD PMID:15668341 MGI:MGI:3624267 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Il10 interleukin 10 IDA RGD PMID:17017555 RGD:1598631 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il4 interleukin 4 IDA RGD PMID:18182309 RGD:2317291 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Khsrp KH-type splicing regulatory protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16126846)
Ensembl
UniProt
RGD
PMID:16126846 GO_REF:0000024, GO_REF:0000107 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO
ISS
(PMID:20525224)
GO_REF:0000024
RGD
UniProt
PMID:20525224 GO_REF:0000024 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ptgis prostaglandin I2 synthase ISO
ISS
(PMID:20159982)
GO_REF:0000024
RGD
UniProt
PMID:20159982 GO_REF:0000024 NCBI chr 3:163,950,746...163,986,129 JBrowse link
G Rgn regucalcin IMP RGD PMID:12686401 RGD:9590175 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6271078|PMID:29353861)
(PMID:29353861)
Ensembl
RGD
PMID:29353861 GO_REF:0000107, MGI:MGI:6271078 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Sirpa signal-regulatory protein alpha ISO
IEA
(MGI:MGI:3760575|PMID:17954568)
GO_REF:0000107
RGD
Ensembl
PMID:17954568 GO_REF:0000107, MGI:MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Tspo translocator protein IDA RGD PMID:14678758 RGD:2317158 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Wdr35 WD repeat domain 35 IDA RGD PMID:18671723 RGD:11553926 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISO
ISS
(PMID:18178554)
GO_REF:0000024
(MGI:MGI:5142149|PMID:21616078)
RGD
UniProt
PMID:18178554, PMID:21616078 GO_REF:0000024, MGI:MGI:5142149 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      negative regulation of metabolic process 3307
        negative regulation of biosynthetic process 1702
          negative regulation of reactive oxygen species biosynthetic process 41
            negative regulation of hydrogen peroxide biosynthetic process 5
            negative regulation of nitric oxide biosynthetic process 19
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of metabolic process 6985
          regulation of cellular metabolic process 6234
            regulation of reactive oxygen species metabolic process 218
              regulation of reactive oxygen species biosynthetic process 117
                negative regulation of reactive oxygen species biosynthetic process 41
                  negative regulation of hydrogen peroxide biosynthetic process 5
                  negative regulation of nitric oxide biosynthetic process 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.