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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of autophagy of mitochondrion
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Accession:GO:1903599 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy.
Comment:An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay
Synonyms:exact_synonym: up regulation of mitochondrion degradation;   up regulation of mitophagy;   upregulation of mitochondrion degradation;   upregulation of mitophagy
 narrow_synonym: activation of mitophagy
 broad_synonym: positive regulation of mitochondrial degradation
 related_synonym: activation of mitochondrion degradation


show annotations for term's descendants           Sort by:
 
positive regulation of autophagy of mitochondrion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 IMP RGD PMID:23698117 RGD:11561968 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Fbxo7 F-box protein 7 ISO
IBA
IMP
(PMID:26310625)
PMID:21873635
RGD PMID:26310625, PMID:21873635, PMID:26310625 RGD:13792537, RGD:11536096 NCBI chr 7:23,815,246...23,843,505
Ensembl chr 7:23,815,245...23,843,634
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA
(MGI:MGI:3796473|PMID:18281291)
GO_REF:0000107
RGD
Ensembl
PMID:18281291 GO_REF:0000107, MGI:MGI:3796473 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Htt huntingtin IEA
ISO
GO_REF:0000107
(PMID:25686248)
Ensembl
RGD
PMID:25686248 GO_REF:0000107 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:26310625) RGD PMID:26310625 NCBI chr 1:48,880,015...50,069,998 JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vps13c vacuolar protein sorting 13 homolog C ISO
ISS
(PMID:26942284)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:26942284 GO_REF:0000024 NCBI chr 8:73,682,814...73,843,290
Ensembl chr 8:73,682,887...73,842,928
JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 ISO UniProtKB:Q9JK66|UniProtKB:Q9Z2V5 (PMID:20457763) RGD PMID:20457763 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Mfn2 mitofusin 2 ISO (MGI:MGI:5498413|PMID:23620051) RGD PMID:23620051 MGI:MGI:5498413 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Optn optineurin IEA
ISO
GO_REF:0000107
(PMID:25294927)
Ensembl
RGD
PMID:25294927 GO_REF:0000107 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:19029340) RGD PMID:19029340 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO (MGI:MGI:5298125|PMID:22020285) RGD PMID:22020285 MGI:MGI:5298125 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 ISO (PMID:24005319) RGD PMID:24005319 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Gba glucosylceramidase beta ISO (MGI:MGI:5501380|PMID:23707074) RGD PMID:23707074 MGI:MGI:5501380 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Hk2 hexokinase 2 ISO (PMID:23962723) RGD PMID:23962723 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 ISO (MGI:MGI:5581539|PMID:24709290) RGD PMID:24709290 MGI:MGI:5581539 NCBI chr 5:156,855,105...156,864,517
Ensembl chr 5:156,850,206...156,864,517
JBrowse link
G Pink1 PTEN induced kinase 1 IMP RGD PMID:25154397 RGD:12904014 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
positive regulation of mitophagy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:28608965 RGD:13432560 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Vdac1 voltage-dependent anion channel 1 ISO (PMID:32047033) RGD PMID:32047033 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vps13d vacuolar protein sorting 13 homolog D ISO (PMID:29307555) RGD PMID:29307555 NCBI chr 5:162,891,451...163,119,239
Ensembl chr 5:162,891,451...163,119,239
JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO
IEA
(MGI:MGI:5607224|PMID:21855797)
GO_REF:0000107
RGD
Ensembl
PMID:21855797 GO_REF:0000107, MGI:MGI:5607224 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Hdac6 histone deacetylase 6 ISO UniProtKB:Q9JK66 (MGI:MGI:5616310|PMID:20457763) RGD PMID:20457763 MGI:MGI:5616310 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 IEA
ISO
GO_REF:0000107
(PMID:30217973)
Ensembl
RGD
PMID:30217973 GO_REF:0000107 NCBI chr  X:21,474,627...21,603,348
Ensembl chr  X:21,499,934...21,598,876
JBrowse link
G Pink1 PTEN induced kinase 1 ISO (PMID:20871098) RGD PMID:20871098 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:20457763), (PMID:20871098), (PMID:23212910) RGD PMID:20457763, PMID:20871098, PMID:23212910 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO (PMID:24270810) RGD PMID:24270810 NCBI chr 4:7,835,949...7,842,790
Ensembl chr 4:7,835,949...7,842,789
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      process utilizing autophagic mechanism 467
        autophagy 467
          positive regulation of autophagy 158
            positive regulation of autophagy of mitochondrion 20
              positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization + 14
              positive regulation of mitophagy + 12
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          cellular component disassembly 425
            organelle disassembly 111
              mitochondrion disassembly 78
                autophagy of mitochondrion 78
                  regulation of autophagy of mitochondrion 38
                    positive regulation of autophagy of mitochondrion 20
                      positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization + 14
                      positive regulation of mitophagy + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.