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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of IRE1-mediated unfolded protein response
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Accession:GO:1903895 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response.
Synonyms:exact_synonym: down regulation of IRE1 branch of UPR;   down regulation of IRE1-mediated unfolded protein response;   down regulation of UPR signaling by IRE1 stress sensor;   down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling;   downregulation of IRE1 branch of UPR;   downregulation of IRE1-mediated unfolded protein response;   downregulation of UPR signaling by IRE1 stress sensor;   downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling;   negative regulation of IRE1 branch of UPR;   negative regulation of UPR signaling by IRE1 stress sensor;   negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling
 narrow_synonym: down regulation of IRE1alpha unfolded protein response;   down regulation of IRE1p unfolded protein response;   downregulation of IRE1alpha unfolded protein response;   downregulation of IRE1p unfolded protein response;   inhibition of IRE1 branch of UPR;   inhibition of IRE1-mediated unfolded protein response;   inhibition of IRE1alpha unfolded protein response;   inhibition of IRE1p unfolded protein response;   inhibition of UPR signaling by IRE1 stress sensor;   inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling;   negative regulation of IRE1alpha unfolded protein response;   negative regulation of IRE1p unfolded protein response
 related_synonym: down regulation of IRE1 signaling in response to endoplasmic reticulum stress;   down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction;   downregulation of IRE1 signaling in response to endoplasmic reticulum stress;   downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction;   inhibition of IRE1 signaling in response to endoplasmic reticulum stress;   inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction;   negative regulation of ERN1-mediated unfolded protein response;   negative regulation of IRE1 signaling in response to endoplasmic reticulum stress;   negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction


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negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,464,658...1,471,152
NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Ddrgk1 DDRGK domain containing 1 ISO
IEA
(PMID:28128204), (PMID:32160526)
(MGI:MGI:5912977|PMID:28128204)
GO_REF:0000107
RGD
Ensembl
PMID:28128204, PMID:32160526 GO_REF:0000107, MGI:MGI:5912977 NCBI chr 3:123,195,580...123,206,828
Ensembl chr 3:123,195,580...123,206,828
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO (MGI:MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:MGI:5571560 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Ufl1 Ufm1-specific ligase 1 ISO
ISS
(PMID:32160526)
GO_REF:0000024
RGD
UniProt
PMID:32160526 GO_REF:0000024 NCBI chr 5:39,616,479...39,650,894
Ensembl chr 5:39,615,956...39,650,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        endoplasmic reticulum unfolded protein response 72
          IRE1-mediated unfolded protein response 15
            negative regulation of IRE1-mediated unfolded protein response 6
Path 2
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      cellular response to stimulus 8906
        cellular response to chemical stimulus 3517
          cellular response to organic substance 2836
            cellular response to topologically incorrect protein 122
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response 72
                  regulation of endoplasmic reticulum unfolded protein response 25
                    regulation of IRE1-mediated unfolded protein response 10
                      negative regulation of IRE1-mediated unfolded protein response 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.