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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of PERK-mediated unfolded protein response
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Accession:GO:1903897 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response.
Synonyms:exact_synonym: regulation of PERK branch of UPR;   regulation of PKR-like ER kinase signal transduction;   regulation of UPR signaling by PERK stress sensor;   regulation of endoplasmic reticulum unfolded protein response; PERK signaling
 broad_synonym: regulation of PERK signal transduction pathway
 related_synonym: regulation of EIF2AK3-mediated unfolded protein response;   regulation of PERK signaling in response to endoplasmic reticulum stress


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negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      signal transduction 6968
        ER-nucleus signaling pathway 41
          PERK-mediated unfolded protein response 11
            regulation of PERK-mediated unfolded protein response 7
              negative regulation of PERK-mediated unfolded protein response 3
              positive regulation of PERK-mediated unfolded protein response 4
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      response to chemical 6305
        response to organic substance 3832
          response to topologically incorrect protein 142
            response to unfolded protein 117
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response 72
                  regulation of endoplasmic reticulum unfolded protein response 25
                    regulation of PERK-mediated unfolded protein response 7
                      negative regulation of PERK-mediated unfolded protein response 3
                      positive regulation of PERK-mediated unfolded protein response 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.