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ONTOLOGY REPORT - ANNOTATIONS


Term:midbrain dopaminergic neuron differentiation
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Accession:GO:1904948 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron.
Synonyms:exact_synonym: DA neurogenesis from midbrain floor plate;   mDA neuron differentiation;   midbrain DA neurogenesis;   midbrain dopaminergic neuron production


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midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Lmx1a LIM homeobox transcription factor 1 alpha JBrowse link 13 85,916,753 86,061,534 RGD:1624291
RGD:1600115
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Ryk receptor-like tyrosine kinase JBrowse link 8 111,326,339 111,398,640 RGD:1624291
RGD:1600115
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:1624291
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
RGD:1600115
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:1624291
RGD:1600115
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:1624291
RGD:1600115
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:1624291
RGD:1600115
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:10448953
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    developmental process 6647
      anatomical structure development 6113
        midbrain development 55
          midbrain dopaminergic neuron differentiation 13
            Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 6
            negative regulation of midbrain dopaminergic neuron differentiation + 0
            positive regulation of midbrain dopaminergic neuron differentiation + 2
            regulation of midbrain dopaminergic neuron differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 19317
    developmental process 6647
      anatomical structure development 6113
        multicellular organism development 5583
          system development 5101
            nervous system development 2597
              neurogenesis 1882
                generation of neurons 1747
                  neuron differentiation 1574
                    dopaminergic neuron differentiation 37
                      midbrain dopaminergic neuron differentiation 13
                        Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + 6
                        negative regulation of midbrain dopaminergic neuron differentiation + 0
                        positive regulation of midbrain dopaminergic neuron differentiation + 2
                        regulation of midbrain dopaminergic neuron differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.