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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of guanyl-nucleotide exchange factor activity
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Accession:GO:1905098 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
Synonyms:exact_synonym: down regulation of GDP-dissociation stimulator activity;   down regulation of GDS;   down regulation of GEF;   down regulation of guanyl-nucleotide exchange factor activity;   down regulation of guanyl-nucleotide release factor activity;   down regulation of guanyl-nucleotide releasing factor;   downregulation of GDP-dissociation stimulator activity;   downregulation of GDS;   downregulation of GEF;   downregulation of guanyl-nucleotide exchange factor activity;   downregulation of guanyl-nucleotide release factor activity;   downregulation of guanyl-nucleotide releasing factor;   negative regulation of GDP-dissociation stimulator activity;   negative regulation of GDS;   negative regulation of GEF;   negative regulation of guanyl-nucleotide release factor activity;   negative regulation of guanyl-nucleotide releasing factor
 narrow_synonym: down regulation of GNRP;   downregulation of GNRP;   inhibition of GDP-dissociation stimulator activity;   inhibition of GDS;   inhibition of GEF;   inhibition of GNRP;   inhibition of guanyl-nucleotide exchange factor activity;   inhibition of guanyl-nucleotide release factor activity;   inhibition of guanyl-nucleotide releasing factor;   negative regulation of GNRP


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negative regulation of guanyl-nucleotide exchange factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2B1 eukaryotic translation initiation factor 2B subunit alpha ISO RGD PMID:9582312 RGD:1581075 NCBI chr12:121,206,380...121,218,749
Ensembl chr12:125,433,227...125,446,665
JBrowse link
G EIF2B4 eukaryotic translation initiation factor 2B subunit delta ISO RGD PMID:9582312 RGD:1581075 NCBI chr2A:27,368,189...27,374,265
Ensembl chr2A:27,456,457...27,462,706
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha ISO RGD PMID:9582312 RGD:1581075 NCBI chr14:47,935,691...47,960,055
Ensembl chr14:66,813,953...66,839,866
JBrowse link
G GPSM1 G protein signaling modulator 1 ISO (PMID:11024022) UniProtKB PMID:11024022 NCBI chr 9:107,400,819...107,432,165
Ensembl chr 9:136,383,929...136,410,561
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO (PMID:25198505) CAFA PMID:25198505 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159
JBrowse link
G STMN1 stathmin 1 ISO (PMID:25198505) CAFA PMID:25198505 NCBI chr 1:25,159,241...25,165,535
Ensembl chr 1:26,208,731...26,230,925
JBrowse link
negative regulation of Rho guanyl-nucleotide exchange factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RIPOR1 RHO family interacting cell polarization regulator 1 ISO (PMID:25588844) UniProtKB PMID:25588844 NCBI chr16:47,872,769...47,890,776
Ensembl chr16:67,268,180...67,278,445
JBrowse link
G RIPOR2 RHO family interacting cell polarization regulator 2 ISO (PMID:23241886)
(MGI:MGI:5887189|PMID:25588844)
UniProtKB PMID:23241886, PMID:25588844 MGI:MGI:5887189 NCBI chr 6:24,642,239...24,768,074
Ensembl chr 6:24,973,412...25,204,745
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    biological regulation 9168
      regulation of molecular function 2244
        negative regulation of molecular function 901
          negative regulation of guanyl-nucleotide exchange factor activity 8
            negative regulation of Rho guanyl-nucleotide exchange factor activity 2
Path 2
Term Annotations click to browse term
  biological_process 12561
    biological regulation 9168
      regulation of molecular function 2244
        regulation of catalytic activity 1561
          regulation of hydrolase activity 801
            regulation of GTPase activity 231
              regulation of guanyl-nucleotide exchange factor activity 11
                negative regulation of guanyl-nucleotide exchange factor activity 8
                  negative regulation of Rho guanyl-nucleotide exchange factor activity 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.