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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation


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regulation of amyloid fibril formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1600115
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1600115
RGD:1624291
negative regulation of amyloid fibril formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1624291
RGD:1600115
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:1624291
G Hspg2 heparan sulfate proteoglycan 2 JBrowse link 5 155,812,096 155,913,751 RGD:1624291
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1600115
RGD:1624291
positive regulation of amyloid fibril formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19335
    metabolic process 11555
      primary metabolic process 10411
        protein metabolic process 5973
          regulation of protein metabolic process 2928
            regulation of amyloid fibril formation 8
              negative regulation of amyloid fibril formation 5
              positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 19335
    metabolic process 11555
      nitrogen compound metabolic process 9892
        organonitrogen compound metabolic process 6852
          protein metabolic process 5973
            regulation of protein metabolic process 2928
              regulation of amyloid fibril formation 8
                negative regulation of amyloid fibril formation 5
                positive regulation of amyloid fibril formation 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.