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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid fibril formation
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Accession:GO:1905907 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: down regulation of amyloid fibril formation;   downregulation of amyloid fibril formation
 narrow_synonym: inhibition of amyloid fibril formation
 related_synonym: down regulation of amyloid fibril assembly;   down regulation of amyloid structure assembly;   down regulation of amyloid structure formation;   downregulation of amyloid fibril assembly;   downregulation of amyloid structure assembly;   downregulation of amyloid structure formation;   inhibition of amyloid fibril assembly;   inhibition of amyloid structure assembly;   inhibition of amyloid structure formation;   negative regulation of amyloid fibril assembly;   negative regulation of amyloid structure assembly;   negative regulation of amyloid structure formation


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negative regulation of amyloid fibril formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:1624291
RGD:1600115
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:1624291
RGD:1600115
G Hspg2 heparan sulfate proteoglycan 2 JBrowse link 5 155,812,096 155,913,751 RGD:1624291
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19312
    metabolic process 11535
      negative regulation of metabolic process 3065
        negative regulation of macromolecule metabolic process 2785
          negative regulation of protein metabolic process 1179
            negative regulation of amyloid fibril formation 5
Path 2
Term Annotations click to browse term
  biological_process 19312
    biological regulation 13339
      regulation of biological process 12655
        regulation of metabolic process 6536
          negative regulation of metabolic process 3065
            negative regulation of macromolecule metabolic process 2785
              negative regulation of protein metabolic process 1179
                negative regulation of amyloid fibril formation 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.