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ONTOLOGY REPORT - ANNOTATIONS


Term:response to nerve growth factor
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Accession:GO:1990089 term browser browse the term
Definition:A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
Synonyms:exact_synonym: response to nerve growth factor stimulus


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response to nerve growth factor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor ISO RGD PMID:10366647 RGD:8657096 NCBI chrNW_004955476:6,773,244...6,822,201 JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 ISO brain-derived neurotrophic factor, neurotrophin 4
brain-derived neurotrophic factor, neurotrophin-3
RGD PMID:9526005, PMID:18775767 RGD:9685724, RGD:9685735 NCBI chrNW_004955414:32,538,968...32,580,370 JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 ISO neurotrophin 4 RGD PMID:18775767 RGD:9685735 NCBI chrNW_004955405:14,420,447...14,599,780 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:11356687 RGD:10412693 NCBI chrNW_004955408:391,094...430,638 JBrowse link
G Ptn pleiotrophin ISO ciliary neurotrophic factor RGD PMID:16914133 RGD:9831439 NCBI chrNW_004955494:5,580,264...5,681,848 JBrowse link
cellular response to brain-derived neurotrophic factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crnkl1 crooked neck pre-mRNA splicing factor 1 ISO RGD PMID:12801913 RGD:634609 NCBI chrNW_004955415:28,158,351...28,171,335 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO RGD PMID:19625250 RGD:10401254 NCBI chrNW_004955495:4,800,103...4,807,714 JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO RGD PMID:19625250 RGD:10401254 NCBI chrNW_004955493:865,830...922,765 JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 ISO RGD PMID:17632064 RGD:10044262 NCBI chrNW_004955506:2,749,534...2,760,873 JBrowse link
G Irs1 insulin receptor substrate 1 ISO RGD PMID:17467122 RGD:10045898 NCBI chrNW_004955453:7,685,715...7,742,262 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO RGD PMID:11520908 RGD:10045822 NCBI chrNW_004955496:5,842,734...5,950,995 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004955432:2,284,283...2,629,631 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:18971483 RGD:10449508 NCBI chrNW_004955442:14,685,089...14,772,870 JBrowse link
G Sh3gl2 SH3 domain containing GRB2 like 2, endophilin A1 ISO (MGI:MGI:5825424|PMID:21849472) UniProtKB PMID:21849472 MGI:MGI:5825424 NCBI chrNW_004955434:20,332,727...20,381,320 JBrowse link
G Tmem108 transmembrane protein 108 ISO (MGI:MGI:5825407|PMID:27605705), (MGI:MGI:5825424|PMID:21849472) UniProtKB PMID:21849472, PMID:27605705 MGI:MGI:5825407, MGI:MGI:5825424 NCBI chrNW_004955501:5,148,821...5,475,073 JBrowse link
G Ube3a ubiquitin protein ligase E3A ISO RGD PMID:25867122 RGD:11079590 NCBI chrNW_004955533:3,733,148...3,828,353 JBrowse link
G Wasf1 WASP family member 1 ISO (MGI:MGI:5825407|PMID:27605705) UniProtKB PMID:27605705 MGI:MGI:5825407 NCBI chrNW_004955411:34,893,287...34,966,670 JBrowse link
cellular response to nerve growth factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004955420:13,649,482...13,777,353 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PMID:20605787
(PMID:20605787)
UniProt
UniProtKB
PMID:20605787 RGD:10402036 NCBI chrNW_004955538:3,208,711...3,224,386 JBrowse link
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:22399805 RGD:7245986 NCBI chrNW_004955418:2,567,804...2,675,062 JBrowse link
G App amyloid beta precursor protein ISO RGD PMID:10821917 RGD:10054256 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Arf6 ADP ribosylation factor 6 ISO PMID:26446845 UniProt PMID:26446845 RGD:11554955 NCBI chrNW_004955409:12,814,814...12,818,142 JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:10797548 RGD:11049163 NCBI chrNW_004955453:15,117,978...15,145,895 JBrowse link
G Arpc3 actin related protein 2/3 complex subunit 3 ISO RGD PMID:10797548 RGD:11049163 NCBI chrNW_004955482:7,350,456...7,364,266 JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004955476:6,773,244...6,822,201 JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO RGD PMID:11640947 RGD:9586055 NCBI chrNW_004955478:6,990,816...7,088,751 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:12138204 RGD:11567269 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:19546888 RGD:11038823 NCBI chrNW_004955412:20,307,011...20,388,539 JBrowse link
G Cdc5l cell division cycle 5 like ISO RGD PMID:20629186 RGD:10045890 NCBI chrNW_004955437:9,990,613...10,032,034 JBrowse link
G Cib1 calcium and integrin binding 1 ISO (PMID:21215777) UniProtKB PMID:21215777 NCBI chrNW_004955416:15,102,632...15,106,372 JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:18193038 RGD:10059421 NCBI chrNW_004955457:7,424,403...7,490,630 JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:15128873 RGD:1642627 NCBI chrNW_004955481:1,705,595...1,748,363 JBrowse link
G Csnk1d casein kinase 1 delta ISO RGD PMID:21698236 RGD:10059659 NCBI chrNW_004955506:904,659...936,293 JBrowse link
G Csnk1e casein kinase 1 epsilon ISO RGD PMID:21698236 RGD:10059659 NCBI chrNW_004955413:24,560,889...24,591,669 JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 ISO RGD PMID:23948079 RGD:9686373 NCBI chrNW_004955503:6,949,901...6,971,281 JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:10407183 RGD:9588607 NCBI chrNW_004955495:1,465,529...1,505,379 JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO RGD PMID:8922673 RGD:13207348 NCBI chrNW_004955538:1,388,595...1,458,166 JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004955449:3,204,839...3,256,059 JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004955620:46,535...82,595 JBrowse link
G Dync1li2 dynein cytoplasmic 1 light intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004955433:23,262,981...23,286,506 JBrowse link
G E2f1 E2F transcription factor 1 ISO RGD PMID:18367454 RGD:8693614 NCBI chrNW_004955422:27,638,625...27,643,261 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:11907030 RGD:1304240 NCBI chrNW_004955493:8,661,317...8,663,190 JBrowse link
G Ehd1 EH domain containing 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004955422:20,302,409...20,324,591 JBrowse link
G Elavl4 ELAV like RNA binding protein 4 ISO RGD PMID:9514914, PMID:12859688 RGD:1579855, RGD:9685344 NCBI chrNW_004955464:8,699,142...8,847,289 JBrowse link
G Ep300 E1A binding protein p300 ISO RGD PMID:20399742 RGD:7364749 NCBI chrNW_004955413:26,647,553...26,727,875 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:9011767 RGD:10402043 NCBI chrNW_004955463:14,013,247...14,064,354 JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:24183892 RGD:9495918 NCBI chrNW_004955411:33,655,958...33,770,829 JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO RGD PMID:9389649 RGD:9685378 NCBI chrNW_004955420:14,565,921...14,568,447 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:10936191 RGD:11354963 NCBI chrNW_004955419:3,055,420...3,060,208 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:7623812 RGD:9686118 NCBI chrNW_004955422:29,337,969...29,339,178 JBrowse link
G Kat2a lysine acetyltransferase 2A ISO RGD PMID:15496412 RGD:2312271 NCBI chrNW_004955451:16,192,228...16,197,103 JBrowse link
G Kidins220 kinase D interacting substrate 220 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955487:782,683...862,079 JBrowse link
G Kif1b kinesin family member 1B ISO RGD PMID:24469107 RGD:12738402 NCBI chrNW_004955486:3,366,791...3,503,845 JBrowse link
G Kif5a kinesin family member 5A ISO RGD PMID:8963445 RGD:12793074 NCBI chrNW_004955458:5,264,274...5,310,962 JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:3511068 RGD:11570521 NCBI chrNW_004955580:548,442...561,580 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955410:6,739,115...7,295,027 JBrowse link
G Micall1 MICAL like 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004955413:24,264,726...24,290,578 JBrowse link
G Myoc myocilin ISO RGD PMID:17663725 RGD:7401258 NCBI chrNW_004955406:12,182,115...12,194,683 JBrowse link
G Nf1 neurofibromin 1 ISO RGD PMID:8892969 RGD:12789704 NCBI chrNW_004955481:6,145,855...6,404,179 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO PMID:17724123
(MGI:MGI:5571523|PMID:24760869)
(PMID:1281417)
PMID:26446845
UniProt
MGI
UniProtKB
PMID:1281417, PMID:17724123, PMID:24760869, PMID:26446845 MGI:MGI:5571523, RGD:11554955, RGD:8554481 NCBI chrNW_004955545:2,929,704...2,947,579 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004955432:2,284,283...2,629,631 JBrowse link
G Nts neurotensin ISO RGD PMID:7898306 RGD:9743905 NCBI chrNW_004955405:23,696,258...23,758,487 JBrowse link
G Optn optineurin ISO RGD PMID:17663725 RGD:7401258 NCBI chrNW_004955462:1,098,118...1,150,291 JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:10662831 RGD:12801496 NCBI chrNW_004955425:5,007,811...5,091,829 JBrowse link
G Rab35 RAB35, member RAS oncogene family ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004955455:11,484,557...11,502,630 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PMID:17724123 RGD
UniProt
PMID:17724123, PMID:17822405 RGD:10040965, RGD:8554481 NCBI chrNW_004955435:15,090,521...15,171,397 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (PMID:17724123) UniProtKB PMID:17724123 NCBI chrNW_004955513:1,224,418...1,328,176 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955471:12,670,837...12,838,910 JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 ISO RGD PMID:25126967 RGD:9850100 NCBI chrNW_004955449:2,172,354...2,453,367 JBrowse link
G Rpl8 ribosomal protein L8 ISO RGD PMID:11922865 RGD:11039448 NCBI chrNW_004955454:3,397,893...3,400,275 JBrowse link
G Rpl9 ribosomal protein L9 ISO RGD PMID:11922865 RGD:11039448 NCBI chrNW_004955443:7,907,628...7,912,472 JBrowse link
G Rps3 ribosomal protein S3 ISO PMID:20605787 UniProt PMID:20605787 RGD:10402036 NCBI chrNW_004955414:16,436,899...16,442,325 JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:21596853 RGD:8547918 NCBI chrNW_004955456:16,147,523...16,157,040 JBrowse link
G Snx27 sorting nexin 27 ISO RGD PMID:16076023 RGD:13508621 NCBI chrNW_004955589:719,892...799,367 JBrowse link
G Stmn2 stathmin 2 ISO (PMID:21215777) UniProtKB PMID:21215777 NCBI chrNW_004955444:1,585,042...1,646,812 JBrowse link
G Tac1 tachykinin precursor 1 ISO (MGI:MGI:5571523|PMID:24760869) MGI PMID:24760869 MGI:MGI:5571523 NCBI chrNW_004955432:13,991,647...13,999,665 JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004955467:13,221,391...13,239,089 JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO RGD PMID:25662281 RGD:11053004 NCBI chrNW_004955409:3,839,308...3,903,595 JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A ISO (MGI:MGI:5559799|PMID:24270184) MGI PMID:24270184 MGI:MGI:5559799 NCBI chrNW_004955493:6,815,148...6,820,295 JBrowse link
G Kidins220 kinase D interacting substrate 220 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955487:782,683...862,079 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955410:6,739,115...7,295,027 JBrowse link
G Ngf nerve growth factor ISO (MGI:MGI:69378|PMID:7854358)
(MGI:MGI:5559799|PMID:24270184)
MGI PMID:7854358, PMID:24270184 MGI:MGI:5559799, MGI:MGI:69378 NCBI chrNW_004955435:18,581,889...18,633,330 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO (PMID:1281417)
(MGI:MGI:5559799|PMID:24270184)
PMID:17724123
(MGI:MGI:69378|PMID:7854358)
UniProtKB
MGI
UniProt
PMID:1281417, PMID:7854358, PMID:17724123, PMID:24270184 MGI:MGI:5559799, MGI:MGI:69378, RGD:8554481 NCBI chrNW_004955545:2,929,704...2,947,579 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955435:15,090,521...15,171,397 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (PMID:17724123) UniProtKB PMID:17724123 NCBI chrNW_004955513:1,224,418...1,328,176 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004955471:12,670,837...12,838,910 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11857
    response to stimulus 6353
      response to endogenous stimulus 1681
        response to nerve growth factor 78
          cellular response to nerve growth factor stimulus + 74
Path 2
Term Annotations click to browse term
  biological_process 11857
    response to stimulus 6353
      response to chemical 3715
        response to organic substance 2997
          response to growth factor 720
            response to nerve growth factor 78
              cellular response to nerve growth factor stimulus + 74
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.