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ONTOLOGY REPORT - ANNOTATIONS


Term:response to nerve growth factor
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Accession:GO:1990089 term browser browse the term
Definition:A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
Synonyms:exact_synonym: response to nerve growth factor stimulus


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response to nerve growth factor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO RGD PMID:10366647 RGD:8657096 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G KCNC1 potassium voltage-gated channel subfamily C member 1 ISO brain-derived neurotrophic factor, neurotrophin-3
brain-derived neurotrophic factor, neurotrophin 4
RGD PMID:9526005, PMID:18775767 RGD:9685724, RGD:9685735 NCBI chr21:40,273,366...40,315,189
Ensembl chr21:40,273,827...40,315,189
JBrowse link
G KCNC2 potassium voltage-gated channel subfamily C member 2 ISO neurotrophin 4 RGD PMID:18775767 RGD:9685735 NCBI chr10:15,599,428...15,822,579
Ensembl chr10:15,643,962...15,818,097
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO RGD PMID:11356687 RGD:10412693 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
G PTN pleiotrophin ISO ciliary neurotrophic factor RGD PMID:16914133 RGD:9831439 NCBI chr16:11,283,078...11,382,820
Ensembl chr16:11,283,077...11,382,814
JBrowse link
cellular response to brain-derived neurotrophic factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRNKL1 crooked neck pre-mRNA splicing factor 1 ISO RGD PMID:12801913 RGD:634609 NCBI chr24:3,294,607...3,310,846
Ensembl chr24:3,294,616...3,310,702
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 ISO RGD PMID:19625250 RGD:10401254 NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126
JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase ISO RGD PMID:19625250 RGD:10401254 NCBI chr 6:23,368,296...23,433,853
Ensembl chr 6:23,371,546...23,433,929
JBrowse link
G EIF4A3 eukaryotic translation initiation factor 4A3 ISO RGD PMID:17632064 RGD:10044262 NCBI chr 9:1,582,950...1,593,893
Ensembl chr 9:1,582,993...1,593,892
JBrowse link
G IRS1 insulin receptor substrate 1 ISO RGD PMID:17467122 RGD:10045898 NCBI chr25:39,624,554...39,687,991 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 ISO RGD PMID:11520908 RGD:10045822 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:18971483 RGD:10449508 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295
JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 IEA Ensembl GO_REF:0000107 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572
JBrowse link
G TMEM108 transmembrane protein 108 IEA Ensembl GO_REF:0000107 NCBI chr23:29,992,038...30,331,791
Ensembl chr23:29,992,021...30,396,840
JBrowse link
G UBE3A ubiquitin protein ligase E3A ISO RGD PMID:25867122 RGD:11079590 NCBI chr 3:35,347,034...35,442,329
Ensembl chr 3:35,347,064...35,440,256
JBrowse link
G WASF1 WASP family member 1 IEA Ensembl GO_REF:0000107 NCBI chr12:66,833,776...66,897,500
Ensembl chr12:66,833,995...66,897,483
JBrowse link
cellular response to nerve growth factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chr33:30,588,450...30,717,162
Ensembl chr33:30,587,756...30,716,229
JBrowse link
G AKT1 AKT serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G APC APC regulator of WNT signaling pathway ISO RGD PMID:22399805 RGD:7245986 NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993
JBrowse link
G APP amyloid beta precursor protein ISO RGD PMID:10821917 RGD:10054256 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
G ARF6 ADP ribosylation factor 6 ISO PMID:26446845 UniProt PMID:26446845 RGD:11554955 NCBI chr 8:26,445,407...26,449,430
Ensembl chr 8:26,445,647...26,525,530
JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:10797548 RGD:11049163 NCBI chr37:24,914,389...24,935,998
Ensembl chr37:24,914,642...24,935,824
JBrowse link
G ARPC3 actin related protein 2/3 complex subunit 3 ISO RGD PMID:10797548 RGD:11049163 NCBI chr26:8,267,123...8,277,779
Ensembl chr26:8,267,196...8,277,688
JBrowse link
G BDNF brain derived neurotrophic factor ISO RGD PMID:21958434 RGD:8657122 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G BPTF bromodomain PHD finger transcription factor ISO RGD PMID:11640947 RGD:9586055 NCBI chr 9:12,586,107...12,703,296
Ensembl chr 9:12,590,333...12,703,422
JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:12138204 RGD:11567269 NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906
JBrowse link
G CBL Cbl proto-oncogene ISO RGD PMID:19546888 RGD:11038823 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956
JBrowse link
G CDC5L cell division cycle 5 like ISO RGD PMID:20629186 RGD:10045890 NCBI chr12:12,779,936...12,822,978
Ensembl chr12:12,780,010...12,822,801
JBrowse link
G CIB1 calcium and integrin binding 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:53,184,713...53,209,195
Ensembl chr 3:53,184,714...53,188,224
JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:18193038 RGD:10059421 NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556
JBrowse link
G CRK CRK proto-oncogene, adaptor protein ISO RGD PMID:15128873 RGD:1642627 NCBI chr 9:45,594,657...45,627,499
Ensembl chr 9:45,598,899...45,627,589
JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 ISO (MGI:MGI:5571523|PMID:24760869) RGD
MGI
PMID:21958434, PMID:24760869 MGI:MGI:5571523, RGD:8657122 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645
JBrowse link
G CSNK1D casein kinase 1 delta ISO RGD PMID:21698236 RGD:10059659 NCBI chr 9:83,395...110,309
Ensembl chr 9:73,215...110,269
JBrowse link
G CSNK1E casein kinase 1 epsilon ISO RGD PMID:21698236 RGD:10059659 NCBI chr10:26,386,646...26,412,429
Ensembl chr10:26,393,033...26,411,624
JBrowse link
G CSTF2 cleavage stimulation factor subunit 2 ISO RGD PMID:23948079 RGD:9686373 NCBI chr  X:74,758,399...74,782,470
Ensembl chr  X:74,758,496...74,782,194
JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:10407183 RGD:9588607 NCBI chr20:50,872,213...50,928,352
Ensembl chr20:50,879,527...50,928,029
JBrowse link
G DYNC1H1 dynein cytoplasmic 1 heavy chain 1 ISO RGD PMID:8922673 RGD:13207348 NCBI chr 8:69,997,021...70,064,886
Ensembl chr 8:69,997,145...70,064,825
JBrowse link
G DYNC1I2 dynein cytoplasmic 1 intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chr36:16,103,480...16,163,232
Ensembl chr36:16,103,751...16,162,215
JBrowse link
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 ISO RGD PMID:11536324 RGD:13207410 NCBI chr23:12,235,539...12,283,851
Ensembl chr23:12,235,104...12,277,031
JBrowse link
G DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chr 5:82,539,880...82,566,689
Ensembl chr 5:82,539,876...82,563,905
JBrowse link
G E2F1 E2F transcription factor 1 ISO RGD PMID:18367454 RGD:8693614 NCBI chr24:22,895,149...22,904,689
Ensembl chr24:22,878,402...22,904,656
JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:11907030 RGD:1304240 NCBI chr12:35,576,576...35,581,339
Ensembl chr12:35,576,576...35,581,230
JBrowse link
G EHD1 EH domain containing 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chr18:52,291,304...52,312,787
Ensembl chr18:52,291,327...52,311,526
JBrowse link
G ELAVL4 ELAV like RNA binding protein 4 ISO RGD PMID:9514914, PMID:12859688 RGD:1579855, RGD:9685344 NCBI chr15:10,885,161...10,977,383
Ensembl chr15:10,887,347...11,027,621
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO RGD PMID:9011767 RGD:10402043 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261
JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:24183892 RGD:9495918 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:10936191 RGD:11354963 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:7623812 RGD:9686118 NCBI chr24:21,094,339...21,096,276
Ensembl chr24:21,094,755...21,096,276
JBrowse link
G KAT2A lysine acetyltransferase 2A ISO RGD PMID:15496412 RGD:2312271 NCBI chr 9:20,778,434...20,787,057
Ensembl chr 9:20,779,042...20,787,067
JBrowse link
G KIDINS220 kinase D interacting substrate 220 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr17:5,983,208...6,077,609
Ensembl chr17:5,982,938...6,071,165
JBrowse link
G KIF1B kinesin family member 1B ISO RGD PMID:24469107 RGD:12738402 NCBI chr 5:63,367,294...63,516,388
Ensembl chr 5:63,376,820...63,513,476
JBrowse link
G KIF5A kinesin family member 5A ISO RGD PMID:8963445 RGD:12793074 NCBI chr10:1,637,007...1,666,790
Ensembl chr10:1,636,932...1,664,767
JBrowse link
G L1CAM L1 cell adhesion molecule ISO RGD PMID:3511068 RGD:11570521 NCBI chr  X:121,708,695...121,722,819
Ensembl chr  X:121,708,894...121,733,365
JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr18:17,973,058...19,098,785
Ensembl chr18:17,918,928...18,930,059
JBrowse link
G MICALL1 MICAL like 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chr10:26,715,572...26,738,326
Ensembl chr10:26,717,322...26,738,850
JBrowse link
G MYOC myocilin ISO RGD PMID:17663725 RGD:7401258 NCBI chr 7:27,335,314...27,346,821
Ensembl chr 7:27,335,314...27,346,820
JBrowse link
G NF1 neurofibromin 1 ISO RGD PMID:8892969 RGD:12789704 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024
JBrowse link
G NTS neurotensin ISO RGD PMID:7898306 RGD:9743905 NCBI chr15:27,361,002...27,372,232
Ensembl chr15:27,361,002...27,372,232
JBrowse link
G OPTN optineurin ISO RGD PMID:17663725 RGD:7401258 NCBI chr 2:23,356,471...23,390,569
Ensembl chr 2:23,357,237...23,392,511
JBrowse link
G PTEN phosphatase and tensin homolog ISO RGD PMID:10662831 RGD:12801496 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
JBrowse link
G RAB35 RAB35, member RAS oncogene family ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chr26:16,061,872...16,078,489
Ensembl chr26:16,063,043...16,078,481
JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO PMID:17724123 UniProt
RGD
PMID:17724123, PMID:17822405 RGD:10040965, RGD:8554481 NCBI chr17:63,725,812...63,795,359
Ensembl chr17:63,726,248...63,746,881
JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 ISO (PMID:17724123) UniProtKB PMID:17724123 NCBI chr 9:52,429,204...52,566,775
Ensembl chr 9:52,450,597...52,563,778
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 ISS UniProtKB GO_REF:0000024 NCBI chr15:56,133,094...56,353,609
Ensembl chr15:56,174,578...56,352,569
JBrowse link
G RAPGEF4 Rap guanine nucleotide exchange factor 4 ISO RGD PMID:25126967 RGD:9850100 NCBI chr36:17,087,488...17,323,504
Ensembl chr36:17,087,488...17,323,220
JBrowse link
G RPL8 ribosomal protein L8 ISO RGD PMID:11922865 RGD:11039448 NCBI chr13:38,101,879...38,104,772
Ensembl chr13:38,102,010...38,104,770
JBrowse link
G RPL9 ribosomal protein L9 ISO RGD PMID:11922865 RGD:11039448 NCBI chr 3:72,989,526...72,993,944
Ensembl chr 3:72,989,592...72,993,949
JBrowse link
G RPS3 ribosomal protein S3 ISO PMID:20605787 UniProt PMID:20605787 RGD:10402036 NCBI chr21:23,180,515...23,187,034
Ensembl chr21:23,180,515...23,187,034
JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:21596853 RGD:8547918 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link
G SNX27 sorting nexin 27 ISO RGD PMID:16076023 RGD:13508621 NCBI chr17:60,653,719...60,727,928
Ensembl chr17:60,653,732...60,724,253
JBrowse link
G STMN2 stathmin 2 IEA Ensembl GO_REF:0000107 NCBI chr29:27,055,891...27,105,695
Ensembl chr29:27,055,900...27,104,501
JBrowse link
G TAC1 tachykinin precursor 1 IEA Ensembl GO_REF:0000107 NCBI chr14:22,631,106...22,640,283
Ensembl chr14:22,632,642...22,640,258
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:21958434 RGD:8657122 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926
JBrowse link
G USP8 ubiquitin specific peptidase 8 ISO RGD PMID:25662281 RGD:11053004 NCBI chr30:16,341,970...16,408,246
Ensembl chr30:16,342,009...16,408,012
JBrowse link
G ZC3H7B zinc finger CCCH-type containing 7B ISO RGD PMID:20399742 RGD:7364749 NCBI chr10:23,882,379...23,944,850
Ensembl chr10:23,884,981...23,920,131
JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G CORO1A coronin 1A IEA Ensembl GO_REF:0000107 NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818
JBrowse link
G KIDINS220 kinase D interacting substrate 220 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:5,983,208...6,077,609
Ensembl chr17:5,982,938...6,071,165
JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr18:17,973,058...19,098,785
Ensembl chr18:17,918,928...18,930,059
JBrowse link
G NGF nerve growth factor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G NTF3 neurotrophin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr27:39,383,017...39,454,613
Ensembl chr27:39,383,152...39,454,601
JBrowse link
G NTF4 neurotrophin 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:107,371,335...107,377,238
Ensembl chr 1:107,371,335...107,376,987
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr17:63,725,812...63,795,359
Ensembl chr17:63,726,248...63,746,881
JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:52,429,204...52,566,775
Ensembl chr 9:52,450,597...52,563,778
JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 ISS UniProtKB GO_REF:0000024 NCBI chr15:56,133,094...56,353,609
Ensembl chr15:56,174,578...56,352,569
JBrowse link
G SORT1 sortilin 1 IEA GOC GO_REF:0000108 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    response to stimulus 8537
      response to endogenous stimulus 1927
        response to nerve growth factor 82
          cellular response to nerve growth factor stimulus + 78
Path 2
Term Annotations click to browse term
  biological_process 16162
    response to stimulus 8537
      response to chemical 5053
        response to organic substance 3538
          response to growth factor 784
            response to nerve growth factor 82
              cellular response to nerve growth factor stimulus + 78
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.