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ONTOLOGY REPORT - ANNOTATIONS


Term:response to nerve growth factor
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Accession:GO:1990089 term browser browse the term
Definition:A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
Synonyms:exact_synonym: response to nerve growth factor stimulus


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response to nerve growth factor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor ISO RGD PMID:10366647 RGD:8657096 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 ISO brain-derived neurotrophic factor, neurotrophin-3
brain-derived neurotrophic factor, neurotrophin 4
RGD PMID:9526005, PMID:18775767 RGD:9685724, RGD:9685735 NCBI chrNW_004936528:1,351,687...1,393,926 JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 ISO neurotrophin 4 RGD PMID:18775767 RGD:9685735 NCBI chrNW_004936568:3,508,212...3,694,459 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:11356687 RGD:10412693 NCBI chrNW_004936739:551,678...602,027 JBrowse link
G Ptn pleiotrophin ISO ciliary neurotrophic factor RGD PMID:16914133 RGD:9831439 NCBI chrNW_004936592:1,706,979...1,806,345 JBrowse link
cellular response to brain-derived neurotrophic factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crnkl1 crooked neck pre-mRNA splicing factor 1 ISO RGD PMID:12801913 RGD:634609 NCBI chrNW_004936485:328,077...351,323 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO RGD PMID:19625250 RGD:10401254 NCBI chrNW_004936588:2,259,236...2,267,692 JBrowse link
G Eef2k eukaryotic elongation factor 2 kinase ISO RGD PMID:19625250 RGD:10401254 NCBI chrNW_004936501:7,160,134...7,205,231 JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 ISO RGD PMID:17632064 RGD:10044262 NCBI chrNW_004936594:4,148,401...4,160,290 JBrowse link
G Irs1 insulin receptor substrate 1 ISO RGD PMID:17467122 RGD:10045898 NCBI chrNW_004936525:9,064,442...9,125,972 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO RGD PMID:11520908 RGD:10045822 NCBI chrNW_004936520:733,760...850,563 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004936680:267,850...621,467 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO RGD PMID:18971483 RGD:10449508 NCBI chrNW_004936694:1,444,819...1,487,628 JBrowse link
G Tmem108 transmembrane protein 108 ISO (MGI:MGI:5825407|PMID:27605705), (MGI:MGI:5825424|PMID:21849472) UniProtKB PMID:21849472, PMID:27605705 MGI:MGI:5825407, MGI:MGI:5825424 NCBI chrNW_004936529:6,326,775...6,629,247 JBrowse link
G Ube3a ubiquitin protein ligase E3A ISO RGD PMID:25867122 RGD:11079590 NCBI chrNW_004936471:41,187,665...41,290,345 JBrowse link
G Wasf1 WASP family member 1 ISO (MGI:MGI:5825407|PMID:27605705) UniProtKB PMID:27605705 MGI:MGI:5825407 NCBI chrNW_004936564:6,036,135...6,096,046 JBrowse link
cellular response to nerve growth factor stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004936833:73,752...179,057 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:20605787) UniProtKB
UniProt
PMID:20605787 RGD:10402036 NCBI chrNW_004936621:620,163...639,115 JBrowse link
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:22399805 RGD:7245986 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G App amyloid beta precursor protein ISO RGD PMID:10821917 RGD:10054256 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Arf6 ADP ribosylation factor 6 ISO PMID:26446845 UniProt PMID:26446845 RGD:11554955 NCBI chrNW_004936583:181,490...185,466 JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:10797548 RGD:11049163 NCBI chrNW_004936569:758,358...786,995 JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO RGD PMID:11640947 RGD:9586055 NCBI chrNW_004936541:5,261,899...5,396,930 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:12138204 RGD:11567269 NCBI chrNW_004936592:4,728,371...4,833,830 JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:19546888 RGD:11038823 NCBI chrNW_004936542:4,136,389...4,235,746 JBrowse link
G Cdc5l cell division cycle 5 like ISO RGD PMID:20629186 RGD:10045890 NCBI chrNW_004936476:15,647,470...15,698,095 JBrowse link
G Cib1 calcium and integrin binding 1 ISO (PMID:21215777) UniProtKB PMID:21215777 NCBI chrNW_004936483:15,963,863...15,967,458 JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:18193038 RGD:10059421 NCBI chrNW_004936631:3,721,307...3,785,346 JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:15128873 RGD:1642627 NCBI chrNW_004936538:7,581,453...7,609,543 JBrowse link
G Csnk1d casein kinase 1 delta ISO RGD PMID:21698236 RGD:10059659 NCBI chrNW_004936594:5,720,887...5,743,206 JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 ISO RGD PMID:23948079 RGD:9686373 NCBI chrNW_004936584:6,042,785...6,066,758 JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:10407183 RGD:9588607 NCBI chrNW_004936659:520,181...565,496 JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO RGD PMID:8922673 RGD:13207348 NCBI chrNW_004936835:225,879...290,160 JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004936509:1,915,006...1,969,857 JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Dync1li2 dynein cytoplasmic 1 light intermediate chain 2 ISO RGD PMID:11536324 RGD:13207410 NCBI chrNW_004936475:17,012,911...17,036,290 JBrowse link
G E2f1 E2F transcription factor 1 ISO RGD PMID:18367454 RGD:8693614 NCBI chrNW_004936561:6,894,827...6,901,058 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:11907030 RGD:1304240 NCBI chrNW_004936859:740,620...744,534 JBrowse link
G Ehd1 EH domain containing 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004936599:4,451,207...4,473,078 JBrowse link
G Elavl4 ELAV like RNA binding protein 4 ISO RGD PMID:9514914, PMID:12859688 RGD:1579855, RGD:9685344 NCBI chrNW_004936522:10,349,684...10,435,963 JBrowse link
G Ep300 E1A binding protein p300 ISO RGD PMID:20399742 RGD:7364749 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:9011767 RGD:10402043 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:24183892 RGD:9495918 NCBI chrNW_004936564:4,788,036...4,907,600 JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO RGD PMID:9389649 RGD:9685378 NCBI chrNW_004936711:640,002...642,580 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO RGD PMID:10936191 RGD:11354963 NCBI chrNW_004936487:13,348,465...13,352,717 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO RGD PMID:7623812 RGD:9686118 NCBI chrNW_004936485:18,610,721...18,611,889 JBrowse link
G Kat2a lysine acetyltransferase 2A ISO RGD PMID:15496412 RGD:2312271 NCBI chrNW_004936490:16,952,698...16,960,424 JBrowse link
G Kidins220 kinase D interacting substrate 220 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936532:5,270,338...5,368,160 JBrowse link
G Kif1b kinesin family member 1B ISO RGD PMID:24469107 RGD:12738402 NCBI chrNW_004936623:4,091,093...4,222,510 JBrowse link
G Kif5a kinesin family member 5A ISO RGD PMID:8963445 RGD:12793074 NCBI chrNW_004936646:1,697,531...1,730,376 JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:3511068 RGD:11570521 NCBI chrNW_004936809:736,385...768,822 JBrowse link
G LOC101956249 optineurin ISO RGD PMID:17663725 RGD:7401258 NCBI chrNW_004936862:488,591...516,819 JBrowse link
G LOC101978301 uncharacterized LOC101978301 ISO RGD PMID:10797548 RGD:11049163 NCBI chrNW_004936558:3,418,664...3,421,693 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936479:21,373,917...22,062,498 JBrowse link
G Micall1 MICAL like 1 ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004936492:3,200,754...3,227,983 JBrowse link
G Myoc myocilin ISO RGD PMID:17663725 RGD:7401258 NCBI chrNW_004936481:15,544,733...15,556,813 JBrowse link
G Nf1 neurofibromin 1 ISO RGD PMID:8892969 RGD:12789704 NCBI chrNW_004936538:3,394,623...3,596,025 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO PMID:17724123
(PMID:1281417)
(MGI:MGI:5571523|PMID:24760869)
PMID:26446845
UniProt
UniProtKB
MGI
PMID:1281417, PMID:17724123, PMID:24760869, PMID:26446845 MGI:MGI:5571523, RGD:11554955, RGD:8554481 NCBI chrNW_004936580:6,002,168...6,021,690 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004936680:267,850...621,467 JBrowse link
G Nts neurotensin ISO RGD PMID:7898306 RGD:9743905 NCBI chrNW_004936507:3,318,982...3,329,248 JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:10662831 RGD:12801496 NCBI chrNW_004936735:1,252,414...1,338,318 JBrowse link
G Rab35 RAB35, member RAS oncogene family ISO PMID:23572513 UniProt PMID:23572513 RGD:8554201 NCBI chrNW_004936668:795,477...812,187 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PMID:17724123 UniProt
RGD
PMID:17724123, PMID:17822405 RGD:10040965, RGD:8554481 NCBI chrNW_004936690:275,840...363,752 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (PMID:17724123) UniProtKB PMID:17724123 NCBI chrNW_004936487:18,305,537...18,411,170 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936576:5,583,847...5,746,583 JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 ISO RGD PMID:25126967 RGD:9850100 NCBI chrNW_004936509:2,722,279...3,006,436 JBrowse link
G Rpl8 ribosomal protein L8 ISO RGD PMID:11922865 RGD:11039448 NCBI chrNW_004936470:7,538,835...7,541,192 JBrowse link
G Rpl9 ribosomal protein L9 ISO RGD PMID:11922865 RGD:11039448 NCBI chrNW_004936482:7,063,294...7,068,235 JBrowse link
G Rps3 ribosomal protein S3 ISO PMID:20605787 UniProt PMID:20605787 RGD:10402036 NCBI chrNW_004936498:4,198,189...4,204,531 JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:21596853 RGD:8547918 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
G Snx27 sorting nexin 27 ISO RGD PMID:16076023 RGD:13508621 NCBI chrNW_004936580:1,815,582...1,893,076 JBrowse link
G Stmn2 stathmin 2 ISO (PMID:21215777) UniProtKB PMID:21215777 NCBI chrNW_004936871:519,611...572,429 JBrowse link
G Tac1 tachykinin precursor 1 ISO (MGI:MGI:5571523|PMID:24760869) MGI PMID:24760869 MGI:MGI:5571523 NCBI chrNW_004936585:2,932,783...2,941,141 JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:21958434 RGD:8657122 NCBI chrNW_004936677:277,304...326,907 JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO RGD PMID:25662281 RGD:11053004 NCBI chrNW_004936471:12,463,189...12,524,148 JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1a coronin 1A ISO (MGI:MGI:5559799|PMID:24270184) MGI PMID:24270184 MGI:MGI:5559799 NCBI chrNW_004936501:12,338,542...12,344,236 JBrowse link
G Kidins220 kinase D interacting substrate 220 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936532:5,270,338...5,368,160 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936479:21,373,917...22,062,498 JBrowse link
G Ngf nerve growth factor ISO (MGI:MGI:69378|PMID:7854358)
(MGI:MGI:5559799|PMID:24270184)
MGI PMID:7854358, PMID:24270184 MGI:MGI:5559799, MGI:MGI:69378 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO (MGI:MGI:69378|PMID:7854358)
(MGI:MGI:5559799|PMID:24270184)
(PMID:1281417)
PMID:17724123
MGI
UniProtKB
UniProt
PMID:1281417, PMID:7854358, PMID:17724123, PMID:24270184 MGI:MGI:5559799, MGI:MGI:69378, RGD:8554481 NCBI chrNW_004936580:6,002,168...6,021,690 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936690:275,840...363,752 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (PMID:17724123) UniProtKB PMID:17724123 NCBI chrNW_004936487:18,305,537...18,411,170 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936576:5,583,847...5,746,583 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    response to stimulus 6404
      response to endogenous stimulus 1690
        response to nerve growth factor 76
          cellular response to nerve growth factor stimulus + 72
Path 2
Term Annotations click to browse term
  biological_process 11962
    response to stimulus 6404
      response to chemical 3741
        response to organic substance 3010
          response to growth factor 718
            response to nerve growth factor 76
              cellular response to nerve growth factor stimulus + 72
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.